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Panthers vs Penguins Prediction, Picks, NHL Odds for Thursday, October 22

Panthers vs Penguins Prediction, Picks, NHL Odds for Thursday, October 22 article feature image
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Pictured: Pittsburgh Penguins center Sidney Crosby. (Credit: Rob Gray-Imagn Images)

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The Florida Panthers (5-3-2) and Pittsburgh Penguins (3-6-1) will meet in the NHL tonight. Puck drop is set for 7:00 p.m. EDT at PPG Paints Arena in Pittsburgh, Pa. The game will broadcast live on ESPN+.

The Penguins are favored at -115 on the moneyline, with the Panthers at -105 to pull off the upset. The over/under is set at 6.5 (-140o / +114u).

Let's get into our Panthers vs. Penguins predictions and NHL picks.


Panthers vs. Penguins Prediction

Our Florida vs. Pittsburgh best bet is on the Penguins to win outright, with the best odds currently available at FanDuel. For all of your NHL bets, be sure to find the best lines by using our live NHL odds page.

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Panthers vs Penguins Odds

Panthers Logo
Thursday, Oct 22
7 p.m. ET
ESPN+
Penguins Logo
Panthers Odds
SpreadTotalMoneyline
+1.5
-240
6.5
-140o / 114u
-105
Penguins Odds
SpreadTotalMoneyline
-1.5
+190
6.5
-140o / 114u
-115
Odds via FanDuel. Get up-to-the-minute NHL odds here.
FanDuel Logo
  • Panthers vs. Penguins puck line: Panthers +1.5 (-240), Penguins -1.5 (+190)
  • Panthers vs. Penguins over/under: 6.5 (-140o / +114u)
  • Panthers vs. Penguins moneyline: Panthers -105, Penguins -115
  • Panthers vs. Penguins best bet: Penguins Moneyline
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Panthers vs. Penguins Preview

The Pittsburgh Penguins enter the contest sporting a 3-6-1 record overall, though they have maintained a winning 2-1-0 mark on home ice.

The Penguins are currently trapped in a four-game losing skid and have struggled in tight contests, going 1-2-0 in one-goal decisions.

Across the ice, the Florida Panthers carry a 5-3-2 record into the matchup, including a steady 3-2-2 record on the road.

A key structural dynamic to watch in this Eastern Conference battle is discipline, as Florida leads the entire NHL in undisciplined play with 60 total penalty minutes, averaging 6.0 penalties per game.

Backing the Pittsburgh Penguins on the moneyline offers strong value in this spot, as the matchup aligns directly with the "Off a Heart Breaker" Bet Labs system created by analyst Evan Abrams. This system highlights NHL home favorites coming off a narrow single-goal defeat, a spot that delivers a significant psychological advantage as teams return to home ice with elevated urgency.

Pittsburgh fits the criteria after falling 5-4 to the Utah Mammoth on Monday night, where a late third-period push fell just one goal short. That close defeat demonstrates that Pittsburgh's underlying offensive creation remains solid despite the final result.

Returning home provides the Penguins controlled line matchups, better rest, and an ideal bounce-back spot against a Florida side that may underestimate their desperation.

The market consistently undervalues home teams in this rebound role, making Pittsburgh well-positioned to convert Monday's frustration into a disciplined home victory.

Best Bet: Penguins Moneyline (-115)



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