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Golden Knights vs Blues Prediction, Picks, NHL Odds for Thursday, October 22

Golden Knights vs Blues Prediction, Picks, NHL Odds for Thursday, October 22 article feature image
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Candice Ward-Imagn Images. Pictured: Golden Knights right wing Mark Stone (61).

The Vegas Golden Knights (8-2-0) and St. Louis Blues (3-4-1) will meet in the NHL tonight. Puck drop is set for 8:00 p.m. EDT at Enterprise Center in St. Louis, Mo. The game will broadcast live on ESPN+.

The Golden Knights are favored at -125 on the moneyline, with the Blues listed at +105 to pull off the upset. The over/under is set at 6.5 (+114/-135).

Let's get into our Golden Knights vs. Blues predictions and NHL picks.


Golden Knights vs. Blues Prediction

Our Vegas vs. St. Louis best bet is on the Golden Knights to cover the puckline, with the best odds currently available at DraftKings. For all of your NHL bets, be sure to find the best lines by using our live NHL odds page.

Make sure to download the Action Network app for more NHL picks and for even more Action Network content, be sure to add us as a preferred source on Google.

Golden Knights vs Blues Odds

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  • Golden Knights vs. Blues puck line: Vegas -1.5 (+200), St. Louis (-245)
  • Golden Knights vs. Blues over/under: 6.5 (+134/-114)
  • Golden Knights vs. Blues moneyline: Golden Knights -125, Blues +105
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Golden Knights vs. Blues Preview

The Golden Knights and the Blues will meet for the first time this season when they face off in St. Louis tonight.

Vegas has started the season strong, going 8-3 and is 7-1 when scoring three or more goals. St. Louis, on the other hand, has had more inconsistent results, heading into this game with a 4-4-1 record.

This Western Conference matchup has triggered a play for the Bet Labs system, Road Favorites, Conference Mid Dogs. This system focuses on betting NHL moneyline favorites in conference matchups during the regular season, specifically when they are on the road and in higher-total games.

The strategy banks on consistent performance from quality teams that are undervalued on the road due to public bias, especially in games expected to have more scoring (totals ≥ 6). By isolating recent seasons, it reflects modern scoring trends and market dynamics in conference play.

The total for this matchup is on the board at 6.5, which has us targeting the Golden Knights on the moneyline.

Best Bet: Golden Knights (-125)



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