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Toronto Maple Leafs vs. Buffalo Sabres NHL Prediction, Pick, Odds, for Friday, October 24

Toronto Maple Leafs vs. Buffalo Sabres NHL Prediction, Pick, Odds, for Friday, October 24 article feature image
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Photo Credit: John E. Sokolowski-Imagn Images
Pictured: John Tavares

The Toronto Maple Leafs (3-3-1) and Buffalo Sabres (3-4-0) meet in the NHL tonight. Puck drop is set for 7:00 p.m. EDT at KeyBank Center in Buffalo, N.Y. The game will be broadcast live on ESPN+.

The Maple Leafs are favored by -1.5 on the puck line, with the over/under set at 6.5 (+105o / -125u). The Maple Leafs are a -125 favorite to win outright, while the Sabres are +105 to pull off the upset.

Let's get into my Maple Leafs vs. Sabres predictions and NHL picks.

Maple Leafs vs. Sabres Odds, Pick

Maple Leafs Logo
Friday, October 24, 2025
7:00 p.m. EDT
ESPN+
Sabres Logo
Maple Leafs Odds
SpreadTotalMoneyline
-1.5
+190
6.5
+105o / -125u
-125
Sabres Odds
SpreadTotalMoneyline
+1.5
-240
6.5
+105o / -125u
+105
Odds via bet365. Get up-to-the-minute NHL odds here.
bet365 Logo

Maple Leafs vs. Sabres Spread: Maple Leafs -1.5 (+190), Sabres +1.5 (-240)

Maple Leafs vs. Sabres Over/Under: 6.5 (+105o / -125u)

Maple Leafs vs. Sabres Moneyline: Maple Leafs -125, Sabres +105

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Maple Leafs vs. Sabres Preview

The "Well Rested Visiting Faves" system in NHL moneyline betting focuses on the advantage of strong road favorites who enter a matchup against weaker, non-playoff caliber opponents with several days of rest.

The angle highlights that rest allows these favorites to reset physically and prepare strategically, while still maintaining the higher-quality edge that comes with being favored. Facing an opponent that failed to reach the postseason the previous year adds another layer, as these teams often lack consistency and resilience over the long season.

Playing on the road removes distractions and sharpens focus, and when a superior team has three to four days off, they are less likely to suffer from travel fatigue. This combination of rest, opponent weakness, and the role of the favorite has proven to deliver profitable long-term results.


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Maple Leafs vs. Sabres Prediction

Overall, the system stands at 785-460 (63%) with a 7% ROI across all-time results, and it's off to a 7-4 (64%) start this season with a 4% ROI.

Best Bet: Maple Leafs Moneyline

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