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Brentford vs Manchester United Prediction, Picks, EPL Odds for Saturday, September 27

Brentford vs Manchester United Prediction, Picks, EPL Odds for Saturday, September 27 article feature image
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Photo by Getty Images. Pictured: Bruno Fernandes

Manchester United (2-2-1) and Brentford (1-3-1) will face off today at 7:30 a.m. EDT at Brentford Community Stadium in Brentford, England.

Man U is favored at a +100 price, with the over/under set at 2.5 (-160o / +115u) goals.

Let's get into my Man U vs. Brentford prediction.

Playbook

Man U vs. Brentford Prediction

Picks: BTTS – Yes & Over 2.5 Goals
My Man U vs. Brentford best bets are on both teams to score and Over 2.5 goals total in this match.

Man U vs. Brentford Odds

Man U Logo
Saturday, Sep 27
7:30 a.m. ET
Brentford Logo
Man U Odds
SpreadTotalMoneyline
-0.5
-110
2.5
-160o / 115u
+100
Brentford Odds
SpreadTotalMoneyline
+0.5
-135
2.5
-160o / 115u
+240
Odds via BetMGM. Get up-to-the-minute EPL odds here.
BetMGM Logo

Man U vs. Brentford Picks

Picks: BTTS- Yes (-175) & Over 2.5 Goals (-150)

A home victory against Aston Villa (1-0) and the recent 2-2 draw with Chelsea are encouraging signs for Brentford, also suggesting that Manchester United might not have it all their own way on the weekend.

The Bees outmuscled Chelsea on the underlying data last time out: 1.43xG vs 1.25xG. Brentford (1.21xG) did the same (1.19xG) against a Villa side that is clearly underperforming right now.

However, with Brentford’s penchant for scoring at home, aligned with United’s wealth of attacking options and defensive concerns, might this be a game full of goals?

It should be noted that the Red Devils lead the Premier League in terms of expected goals this season, with 10.1 xG.

The last time Brentford hosted Manchester United, they secured a 4-3 win in May, just four months ago. Yoanne Wissa and Brian Mbeumo may have departed, but this is still a team that can find the back of the net.

Man U vs. Brentford Projections

Projected Chance of Winning

Man UDrawBrentford
43.3%23.9%32.8%

Man U vs. Brentford Betting Analysis

At Manchester United, we have a set of players and a manager who are out of form and lacking belief and confidence. Ruben Amorim’s first season as United boss oversaw the third-least profitable campaign of all 20 clubs. Only Southampton and Leicester, both of which were relegated, offered a worse return on investment for punters than United’s -35.1% ROI.

Those kind of numbers, coupled with a winless two away days to open 2025/26, makes a pro-Manchester United selection concerning.

Meanwhile, three consecutive away defeats to open the season for Brentford might suggest that Keith Andrews’ first campaign with the Bees might heavily rely on their home form.

In 2024/25, only Newcastle pipped Brentford in terms of profitability at home in the Asian handicap market. A 5.1% ROI for punters saw the Bees as an attractive proposition at the GTech Community Stadium during the previous campaign.

Regardless, losing away to Forest (3-1), Sunderland (2-1), and Fulham (3-1) last weekend is a poor start to life on Brentford’s travels in 2025/26.

Man U vs. Brentford Projected Starting Lineups

Man U

Bayindir; Yoro, De Ligt, Shaw; Mazraoui, Ugarte, Fernandes, Dorgu; Mbeumo, Cunha; Sesko.

Brentford

Kelleher; Van den Berg, Collins, Pinnock; Kayode, Henderson, Yarmoliuk, Lewis-Potter; Damsgaard; Schade, Thiago.

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