Orioles vs. Guardians Odds & Betting Predictions - July 22, 2025

Orioles at Guardians

10:40 pm • CLEG

Baltimore Orioles

9-7

3 - 6

Cleveland Guardians

10-7

pitcher		team	era	w-l
J.Cantillo			3.21	5-3
B.Young			6.24	1-7

MatchupOpenSpreadTotalMoneyline
Orioles 9-7	+1.5	+1.5-162	o8-108	+135
Guardians 10-7	u8	-1.5+134	u8-111	-161

Tuesday 10:40 p.m.

July 22, 2025

Progressive FieldCleveland

S.Kwan o1.5 Hits + Runs + RBIs-130

CLE -152

0.33u

Under 8-104

1.04u

Flat Favorites at Home (***) Overall: 503-346-38,59% (ROI:15%) Season:10-8-1,56% (ROI:5%) Blowing In Ballparks (***) Overall: 865-541-72,62% (ROI:18%) Season:35-21-1,63% (ROI:19%)

A.Martinez o1.5 Hits + Runs + RBIs-120

$1.00

B.Young u3.5 Ks+124

0.62u

J.Cantillo u6.5 Ks-140

0.5u

Under 8.5-115

Follow @PicksOffice on X.

J.Cantillo u6.5 Ks-135

0.5u

Under 8.5-117

0.59u

BAL +125

CLE -135

CLE -132

0.5u

See notes on F5

CLE -145 (F5)

0.5u

Young 4.31 SIERA/4.65 xERA (LHBs .463 wOBA, .369 xwOBA - CLE can go 9 LHBs), Cantillo struck out 18 of 58 in three starts (all road, 14.9 SwStr%) - BAL 84/76 Rd/v LHP wRC+, CLE far better defense, slightly better pen estimators L30 days and even slightly better base running.

Orioles vs. Guardians: 2 Strikeout Props for Tuesday
Collin Whitchurch•
Jul 22, 2025 UTC
3 MLB Player Props for Tuesday
Alex Hinton•
Jul 22, 2025 UTC

See more MLB Coverage

No props found

MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 3-2 in their last 5 games against the spread
Guardians are 6-5 in their road games against the spread
The totals have gone OVER in 4 of Guardians' last 5 games
The totals have gone OVER in 2 of Guardians' 6 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	11-6	5-1	6-5	3-0	8-6
Orioles	7-9	5-5	2-4	6-6	1-3

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	8-9	2-4	6-5	1-2	7-7
Orioles	9-7	6-4	3-3	6-6	3-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	10-7	4-2	6-5	3-0	7-7
Orioles	9-7	6-4	3-3	8-4	1-3

date	opponent	score	spread	over/under	moneyline
Jul 21st	BAL	W 10-5	-1.5 W	O 8.5	CLE -143
Jul 20th	ATH	W 8-2	+1.5 W	O 7.5	CLE -106
Jul 19th	ATH	L 2-8	-1.5 L	O 9	ATH -134
Jul 18th	ATH	W 8-6	-1.5 W	O 8	CLE -134
Jul 13th	@CWS	W 6-5	-1.5 L	O 8.5	CLE -142

Adley Rutschman
C
Adley Rutschman has been scratched Saturday.
Out
Heston Kjerstad
LF
Kjerstad is out with hamstring
Out
Jordan Westburg
3B
Westburg is out with elbow
Out
Jackson Holliday
2B
Holliday is out with hand
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RB.Young, P	73	4.1	3	3
RA.Kittredge, P	6	0.2	1	0
LG.Soto, P	33	1	2	2
RY.Cano, P	17	1	0	1
RS.Dominguez, P	14	1	0	0

HITTERS	H-AB	R	HR	RBI
1J.Holliday, 2B	1-4	0	0	1
2J.Westburg, DH	0-4	0	0	0
3G.Henderson, SS	0-2	0	0	0
4R.Laureano, RF	1-4	1	1	1
5C.Mullins, CF	0-4	0	0	0
6R.Urias, 3B	2-4	1	0	0
7C.Cowser, LF	1-4	0	0	0
8C.Mayo, 1B	1-1	1	0	0
9J.Stallings, C	0-2	0	0	0
9R.O'Hearn, PH	1-1	0	0	0
9A.Jackson, C	0-1	0	0	0

PITCHER	PC	IP	K	ER
LJ.Cantillo, P	95	5	5	1
LE.Sabrowski, P	23	1.2	2	1
RM.Festa, P	8	0	0	1
RC.Smith, P	31	1.1	1	0
RE.Clase, P	13	1	1	0

HITTERS	H-AB	R	HR	RBI
1S.Kwan, LF	0-5	0	0	0
2A.Martinez, CF	3-5	1	0	1
3J.Ramirez, 3B	1-2	1	1	1
4K.Manzardo, DH	1-3	0	0	2
5C.Santana, 1B	0-4	0	0	0
6N.Jones, RF	0-3	1	0	0
7D.Schneemann, 2B	1-2	1	0	0
8B.Rocchio, SS	1-3	1	0	2
9B.Naylor, C	0-2	1	0	0