The Cleveland Guardians host the Baltimore Orioles on Tuesday, July 22, 2025. First pitch from Progressive Field is scheduled for 6:40 p.m. ET; the game will be broadcast on CLEG and MLB.TV.
The Guardians enter as -142 favorites on the moneyline, while the Orioles are +120 to pull off the upset. The over/under, meanwhile, comes in at 8.5 total runs.
Find my Orioles vs Guardians prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports and more.
Baltimore Orioles vs Cleveland Guardians Prediction, Picks
- Orioles vs. Guardians Picks: Joey Cantillo Under 6.5 Strikeouts (-140) · Brandon Young Under 3.5 Strikeouts (+120)
My Guardians vs. Orioles best bet is on both Cantillo and Young to go under their strikeout totals. Make sure to find the best odds by checking our live MLB odds page.
Orioles vs Guardians Odds, Spread, Lines
| Orioles Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -164 | 8 -109o / -111u | +134 |
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +134 | 8 -109o / -111u | -164 |
Orioles vs Guardians Projected Pitchers
Orioles vs Guardians Preview, Analysis
Cleveland starter Joey Cantillo has been thrown into the fire for the Guardians ever since Luis Ortiz was sidelined due to a gambling investigation.
Cantillo has started three games so far, and in those outings, he’s racked up five, six and seven Ks respectively.
His strikeout total tonight is set at 6.5, which honestly feels a bit off. That’s actually higher than Reds pitcher Chase Burns’ strikeout line, and it doesn’t quite add up.
Now, it’s opponent-relative, but for a pitcher who has topped out at just 89 pitches and has primarily been a reliever, it seems inflated.
On the flip side, Baltimore's Brandon Young has a strikeout total of 3.5 tonight.
He has struck out at least four batters in four of his six starts this season, but the Guardians are a team known for grinding down pitchers. That’s worth considering here.
Orioles vs Guardians Best Bets, Pick
I think both pitchers will come up a little short of their strikeout lines. Cantillo’s total looks high because of how Young has performed recently, but that performance doesn’t quite align with his overall skill level.
So, I’m backing under 6.5 strikeouts for Cantillo and under 3.5 for Young. If you want to combine those into a same-game parlay, it comes in around +240 at DraftKings.
Pick: Joey Cantillo Under 6.5 Strikeouts (-140) · Brandon Young Under 3.5 Strikeouts (+120)
