Twins vs. Guardians Odds & Betting Predictions - July 22, 2026

Twins at Guardians

10:40 pm • MNNT
10 - 6
Starting Pitchers
pitcherteameraw-l
Slade Cecconi logoS.CecconiCleveland Guardians logo5.064-7
Bailey Ober logoB.OberMinnesota Twins logo4.287-5

Twins at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Twins
69-77
+1.5
+1.5-187
o8-111
+118
Guardians
74-73
u7.5
-1.5+153
u8-110
-144
location pinWednesday 10:40 p.m.
July 22, 2026
Progressive FieldCleveland
Twins vs. Guardians Expert Picks
Player Prop Savant
Player Prop Savant
Last 30d: 105-93-2 (+20.6u)
Under 10.5 (Live)-108
1.08u
Under 9.5 (Live)-110
1.1u
OldSchool0909
Last 30d: 84-97-1 (-11.0u)
MIN +125
1.25u
💰🦡 Jake
💰🦡 Jake
Last 30d: 13-22-0 (+4.7u)
Over 8-110
1u
Sean Zerillo
Sean Zerillo
Last 30d: 48-78-3 (-7.0u)
CLE -130
0.65u
Bet to -140
Grant Neiffer
Grant Neiffer
Last 30d: 27-108-2 (+9.0u)
B.Buxton o0.5 HR+350
0.25u
K.Clemens o0.5 HR+480
0.25u
Frank Ammirante
Frank Ammirante
Last 30d: 268-316-7 (-38.6u)
B.Ober u1.5 BB-105
1u
S.Cecconi o15.5 Outs+116
0.86u
C.DeLauter o0.5 HR+496
0.1u
Charlie DiSturco
Charlie DiSturco
Last 30d: 70-150-4 (-3.2u)
B.Buxton To Hit 1+ Home Runs Yes+350
0.25u
Brian Bitler
Brian Bitler
Last 30d: 97-75-0 (+75.5u)
MIN +113
3.39u
Adam Kaufman
Adam Kaufman
Last 30d: 85-97-0 (-26.7u)
CLE -122
1.22u

Twins vs. Guardians Previews & Analysis

  • Charlie DiSturco: 2 HR Picks for Wednesday Night article feature image

    Charlie DiSturco: 2 HR Picks for Wednesday Night

    Charlie Disturco
    Jul 22, 2026 UTC
  • Twins vs Guardians: Today's Best Strikeout Prop article feature image

    Twins vs Guardians: Today's Best Strikeout Prop

    Action Network Staff
    Jul 22, 2026 UTC
  • Derek Carty's 4 MLB Player Props for Wednesday article feature image

    Derek Carty's 4 MLB Player Props for Wednesday

    Action Network Staff
    Jul 22, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Twins vs. Guardians Public Betting Percentages

Away Logo

Twins

Public

26%

Bets%

74%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians
70-7733-4237-3537-5233-21
Twins
74-7236-3638-3620-3152-40

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians
70-7738-3732-4042-4726-28
Twins
79-60-734-34-445-26-326-24-151-35-6

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians
74-7336-3938-3447-4227-27
Twins
69-7738-3431-4326-2541-51

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jul 21stMINW 5-2-1.5 WU 8CLE -157
Jul 20thMINW 13-4+1.5 WO 7.5CLE +111
Jul 19thPITL 1-7+1.5 LO 7PIT -116
Jul 18thPITW 5-3+1.5 WU 8.5CLE -110
Jul 18thPITL 1-7-1.5 LO 7.5PIT -131

Guardians vs. Twins Injury Updates

Guardians Injuries

    Twins Injuries

    • Pablo Lopez
      SP

      Lopez is out with elbow

      Out

    • David Festa
      SP

      Festa is out with shoulder

      Out

    • Travis Adams
      SP

      Adams is out with triceps

      Out

    Twins vs. Guardians Box Score
    Twins Player Stats
    Projected
    PITCHERPCIPKER
    Bailey Ober logoRB.Ober, P89424
    Kody Funderburk logoLK.Funderburk, P22110
    Travis Adams logoRT.Adams, P27200
    Andrew Morris logoRA.Morris, P28111
    Yoendrys Gomez logoRY.Gomez, P14111
    HITTERSH-ABRHRRBI
    Trevor Larnach logo1T.Larnach, LF2-4213
    Austin Martin logo1A.Martin, LF0-0000
    Brooks Lee logo2B.Lee, SS2-5114
    Brooks Lee logo2B.Lee, 3B2-5114
    Kody Clemens logo3K.Clemens, 2B1-5000
    Josh Bell logo4J.Bell, DH1-5002
    Royce Lewis logo5R.Lewis, 3B1-5000
    Royce Lewis logo5R.Lewis, 1B1-5000
    Victor Caratini logo6V.Caratini, 1B0-2000
    Ryan Kreidler logo6R.Kreidler, PH0-3000
    Ryan Kreidler logo6R.Kreidler, SS0-3000
    Alan Roden logo7A.Roden, RF1-4200
    Luke Keaschall logo8L.Keaschall, CF1-3200
    Alex Jackson logo9A.Jackson, C2-4301
    Guardians Player Stats
    Projected
    PITCHERPCIPKER
    Slade Cecconi logoRS.Cecconi, P884.253
    Erik Sabrowski logoLE.Sabrowski, P161.110
    Franco Aleman logoRF.Aleman, P13100
    Matt Festa logoRM.Festa, P200.211
    Will Dion logoLW.Dion, P221.120
    HITTERSH-ABRHRRBI
    Steven Kwan logo1S.Kwan, LF3-5000
    Jose Ramirez logo2J.Ramirez, 3B2-5102
    Chase DeLauter logo3C.DeLauter, DH1-5000
    Brayan Rocchio logo4B.Rocchio, SS2-5101
    Travis Bazzana logo5T.Bazzana, 2B0-3000
    Kyle Manzardo logo6K.Manzardo, 1B3-5212
    Daniel Schneemann logo7D.Schneemann, RF0-5000
    Patrick Bailey logo8P.Bailey, C1-3101
    Petey Halpin logo9P.Halpin, CF1-4100

    Twins vs. Guardians Odds Comparison

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    Twins at Guardians Team Totals

    MatchupOverUnder
    Twins
    69-77
    N/A
    N/A
    Guardians
    74-73
    N/A
    N/A