Twins vs Guardians Odds: Moneyline, Over/Under, Props - July 22, 2026

Twins at Guardians

10:40 pm • MNNT

Minnesota Twins

0-0

10 - 6

Cleveland Guardians

5-6

pitcher		team	era	w-l
S.Cecconi			4.91	5-7
B.Ober			4.47	7-7

MatchupOpenSpreadTotalMoneyline
Twins 0-0	+1.5	+1.5-187	o8-111	+118
Guardians 5-6	u7.5	-1.5+153	u8-110	-144

Wednesday 10:40 p.m.

July 22, 2026

Progressive FieldCleveland

CLE -130

0.65u

Bet to -140

B.Buxton o1.5 Total Bases-108

$1.08

https://discord.gg/QxwqzaSDu

B.Buxton o1.5 Hits + Runs + RBIs-145

$1.45

https://discord.gg/QxwqzaSDu

B.Buxton o0.5 HR+350

0.25u

K.Clemens o0.5 HR+480

0.25u

MIN +125

1.25u

MIN +113

3.39u

C.DeLauter o0.5 HR+496

0.1u

S.Cecconi o15.5 Outs+116

0.86u

B.Ober u1.5 BB-105

Under 9.5 (Live)-110

1.1u

Under 10.5 (Live)-108

1.08u

CLE -122

1.22u

Over 8-110

B.Buxton To Hit 1+ Home Runs Yes+350

0.25u

Charlie DiSturco: 2 HR Picks for Wednesday Night
Charlie Disturco•
Jul 22, 2026 UTC
Twins vs Guardians: Today's Best Strikeout Prop
Action Network Staff•
Jul 22, 2026 UTC
Derek Carty's 4 MLB Player Props for Wednesday
Action Network Staff•
Jul 22, 2026 UTC

See more MLB Coverage

Loading props…

MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 4-1 in their last 5 games against the spread
Guardians are 43-38 in their road games against the spread
The totals have gone OVER in 2 of Guardians' last 5 games
The totals have gone OVER in 42 of Guardians' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	79-83	36-45	43-38	43-55	36-24
Twins	82-80	40-41	42-39	24-34	56-45

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	77-85	42-39	35-46	48-50	27-33
Twins	88-67-7	41-36-4	47-31-3	27-30-1	59-36-6

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	85-77	41-40	44-37	55-43	30-30
Twins	77-85	42-39	35-46	31-27	44-57

date	opponent	score	spread	over/under	moneyline
Jul 21st	MIN	W 5-2	-1.5 W	U 8	CLE -157
Jul 20th	MIN	W 13-4	+1.5 W	O 7.5	CLE +111
Jul 19th	PIT	L 1-7	+1.5 L	O 7	PIT -116
Jul 18th	PIT	W 5-3	+1.5 W	U 8.5	CLE -110
Jul 18th	PIT	L 1-7	-1.5 L	O 7.5	PIT -131

Pablo Lopez
SP
Lopez is out with elbow
Out
David Festa
SP
Festa is out with shoulder
Out
Travis Adams
SP
Adams is out with triceps
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RB.Ober, P	89	4	2	4
LK.Funderburk, P	22	1	1	0
RT.Adams, P	27	2	0	0
RA.Morris, P	28	1	1	1
RY.Gomez, P	14	1	1	1

HITTERS	H-AB	R	HR	RBI
1T.Larnach, LF	2-4	2	1	3
1A.Martin, LF	0-0	0	0	0
2B.Lee, SS	2-5	1	1	4
2B.Lee, 3B	2-5	1	1	4
3K.Clemens, 2B	1-5	0	0	0
4J.Bell, DH	1-5	0	0	2
5R.Lewis, 3B	1-5	0	0	0
5R.Lewis, 1B	1-5	0	0	0
6V.Caratini, 1B	0-2	0	0	0
6R.Kreidler, PH	0-3	0	0	0
6R.Kreidler, SS	0-3	0	0	0
7A.Roden, RF	1-4	2	0	0
8L.Keaschall, CF	1-3	2	0	0
9A.Jackson, C	2-4	3	0	1

PITCHER	PC	IP	K	ER
RS.Cecconi, P	88	4.2	5	3
LE.Sabrowski, P	16	1.1	1	0
RF.Aleman, P	13	1	0	0
RM.Festa, P	20	0.2	1	1
LW.Dion, P	22	1.1	2	0

HITTERS	H-AB	R	HR	RBI
1S.Kwan, LF	3-5	0	0	0
2J.Ramirez, 3B	2-5	1	0	2
3C.DeLauter, DH	1-5	0	0	0
4B.Rocchio, SS	2-5	1	0	1
5T.Bazzana, 2B	0-3	0	0	0
6K.Manzardo, 1B	3-5	2	1	2
7D.Schneemann, RF	0-5	0	0	0
8P.Bailey, C	1-3	1	0	1
9P.Halpin, CF	1-4	1	0	0