Twins vs. Guardians Odds & Betting Predictions - July 22, 2026
Twins at Guardians
10:40 pm • MNNTStarting Pitchers
| pitcher | team | era | w-l | |
|---|---|---|---|---|
![]() | 5.06 | 4-7 | ||
![]() | 4.28 | 7-5 |
Twins at Guardians Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Twins 69-77 | +1.5 | +1.5-187 | o8-111 | +118 |
Guardians 74-73 | u7.5 | -1.5+153 | u8-110 | -144 |

Progressive FieldCleveland
Twins vs. Guardians Expert Picks
Player Prop Savant
Last 30d: 105-93-2 (+20.6u)
Under 10.5 (Live)-108
1.08u
Under 9.5 (Live)-110
1.1u
OldSchool0909
Last 30d: 84-97-1 (-11.0u)
MIN +125
1.25u
💰🦡 Jake
Last 30d: 13-22-0 (+4.7u)
Over 8-110
1u

Sean Zerillo
Last 30d: 48-78-3 (-7.0u)
CLE -130
0.65u
Bet to -140
Grant Neiffer
Last 30d: 27-108-2 (+9.0u)
B.Buxton o0.5 HR+350
0.25u
K.Clemens o0.5 HR+480
0.25u
Frank Ammirante
Last 30d: 268-316-7 (-38.6u)
B.Ober u1.5 BB-105
1u
S.Cecconi o15.5 Outs+116
0.86u
C.DeLauter o0.5 HR+496
0.1u
Charlie DiSturco
Last 30d: 70-150-4 (-3.2u)
B.Buxton To Hit 1+ Home Runs Yes+350
0.25u
Brian Bitler
Last 30d: 97-75-0 (+75.5u)
MIN +113
3.39u
Adam Kaufman
Last 30d: 85-97-0 (-26.7u)
CLE -122
1.22u
Twins vs. Guardians Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Twins vs. Guardians Public Betting Percentages
Betting Trends
- Guardians are 2-3 in their last 5 games.
- Guardians are 1-4 in their last 5 games against the spread
- Guardians are 37-35 in their road games against the spread
- The totals have gone OVER in 3 of Guardians' last 5 games
- The totals have gone OVER in 38 of Guardians' 75 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Guardians vs. Twins Injury Updates

Guardians Injuries

Twins Injuries
- Pablo LopezSP
Lopez is out with elbow
Out
- David FestaSP
Festa is out with shoulder
Out
- Travis AdamsSP
Adams is out with triceps
Out
Twins vs. Guardians Box Score
Twins Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
![]() | 89 | 4 | 2 | 4 | |
![]() | 22 | 1 | 1 | 0 | |
![]() | 27 | 2 | 0 | 0 | |
![]() | 28 | 1 | 1 | 1 | |
![]() | 14 | 1 | 1 | 1 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
![]() | 2-4 | 2 | 1 | 3 |
![]() | 0-0 | 0 | 0 | 0 |
![]() | 2-5 | 1 | 1 | 4 |
![]() | 2-5 | 1 | 1 | 4 |
![]() | 1-5 | 0 | 0 | 0 |
![]() | 1-5 | 0 | 0 | 2 |
![]() | 1-5 | 0 | 0 | 0 |
![]() | 1-5 | 0 | 0 | 0 |
![]() | 0-2 | 0 | 0 | 0 |
![]() | 0-3 | 0 | 0 | 0 |
![]() | 0-3 | 0 | 0 | 0 |
![]() | 1-4 | 2 | 0 | 0 |
![]() | 1-3 | 2 | 0 | 0 |
![]() | 2-4 | 3 | 0 | 1 |
Guardians Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
![]() | 88 | 4.2 | 5 | 3 | |
![]() | 16 | 1.1 | 1 | 0 | |
![]() | 13 | 1 | 0 | 0 | |
![]() | 20 | 0.2 | 1 | 1 | |
![]() | 22 | 1.1 | 2 | 0 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
![]() | 3-5 | 0 | 0 | 0 |
![]() | 2-5 | 1 | 0 | 2 |
![]() | 1-5 | 0 | 0 | 0 |
![]() | 2-5 | 1 | 0 | 1 |
![]() | 0-3 | 0 | 0 | 0 |
![]() | 3-5 | 2 | 1 | 2 |
![]() | 0-5 | 0 | 0 | 0 |
![]() | 1-3 | 1 | 0 | 1 |
![]() | 1-4 | 1 | 0 | 0 |
Twins vs. Guardians Odds Comparison
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Twins at Guardians Team Totals
MatchupOverUnder | ||
|---|---|---|
Twins 69-77 | N/A | N/A |
Guardians 74-73 | N/A | N/A |
































