White Sox vs. Guardians Odds & Betting Predictions - September 15, 2026
White Sox at Guardians
10:40 pm • CHSNStarting Pitchers
| pitcher | team | era | w-l | |
|---|---|---|---|---|
 |  | 5.94 | 3-2 | |
 |  | 3.94 | 3-0 |
White Sox at Guardians Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
White Sox 77-73 | +1.5 | +1.5-170 | o9+100 | +125 |
Guardians 76-75 | u8 | -1.5+140 | u9-119 | -152 |
Progressive FieldCleveland
.webp)
White Sox vs. Guardians Expert Picks
Anthony Dabbundo
Last 30d: 32-35-2 (+2.7u)
Under 9-115
1.15u
Grant Neiffer
Last 30d: 33-111-2 (+12.1u)
M.Murakami o0.5 HR+380
0.25u
Sean Zerillo
Last 30d: 48-66-5 (-6.6u)
Under 8.5-110
0.55u
Bet to 8 (+100)
Matt Trollo
Last 30d: 52-66-2 (-14.6u)
F.Griffin o4.5 Ks+100
0.5u
(Price offered on NOVIG, not yet accepted, would play -110 on B365 too) Has only hit this # 2 of L10, BUT proj CWS LU avg 26.2 K% v LHP.
White Sox vs. Guardians Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
White Sox vs. Guardians Public Betting Percentages
Betting Trends
- Guardians are 2-3 in their last 5 games.
- Guardians are 2-3 in their last 5 games against the spread
- Guardians are 39-36 in their road games against the spread
- The totals have gone OVER in 3 of Guardians' last 5 games
- The totals have gone OVER in 39 of Guardians' 76 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Guardians vs. White Sox Injury Updates
Guardians Injuries
White Sox Injuries
- Mike VasilRP
Vasil is out with elbow
Out
- Ky BushSP
Bush is out with elbow
Out
- Brooks BaldwinLF
Baldwin is out with elbow
Out
- Drew ThorpeSP
Thorpe is out with elbow
Out
White Sox vs. Guardians Starting Lineups
White Sox Starting Lineup| PITCHER | W-L | ERA | WHIP | K/9 | |
|---|---|---|---|---|---|
 | 3-0 | 3.94 | 1.344 | 9.56 |
| HITTERS | AVG | OBP | SLG | HR |
|---|---|---|---|---|
 | .267 | .343 | .397 | 14 |
 | .194 | .212 | .323 | 0 |
 | .249 | .357 | .475 | 31 |
 | .204 | .345 | .465 | 31 |
 | .207 | .207 | .328 | 2 |
 | .269 | .366 | .392 | 8 |
 | .200 | .333 | .200 | 0 |
 | .235 | .266 | .270 | 1 |
 | .277 | .345 | .459 | 12 |
Guardians Starting Lineup| PITCHER | W-L | ERA | WHIP | K/9 | |
|---|---|---|---|---|---|
 | 3-2 | 5.94 | 1.590 | 8.10 |
| HITTERS | AVG | OBP | SLG | HR |
|---|---|---|---|---|
 | .278 | .375 | .346 | 3 |
 | .289 | .362 | .453 | 14 |
 | .230 | .320 | .362 | 11 |
 | .239 | .314 | .413 | 5 |
 | .249 | .343 | .396 | 12 |
 | .221 | .273 | .398 | 5 |
 | .236 | .300 | .327 | 2 |
 | .234 | .298 | .385 | 7 |
 | .247 | .306 | .374 | 13 |
White Sox vs. Guardians Odds Comparison
Could not load odds
White Sox at Guardians Team Totals
MatchupOverUnder | ||
|---|---|---|
White Sox 77-73 | N/A | N/A |
Guardians 76-75 | N/A | N/A |