White Sox vs. Guardians Odds & Betting Predictions - September 15, 2026
White Sox at Guardians
10:40 pm • CHSNStarting Pitchers
| pitcher | team | era | w-l | |
|---|---|---|---|---|
 |  | 5.19 | 3-3 | |
 |  | 4.81 | 3-0 |
White Sox at Guardians Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
White Sox 4-3 | +1.5 | +1.5-166 | o9-110 | +133 |
Guardians 5-6 | u8 | -1.5+134 | u9-116 | -160 |
Progressive FieldCleveland
White Sox vs. Guardians Expert Picks
Sean Zerillo
Last 30d: 134-117-6 (+6.6u)
Under 8.5-110
0.55u
Bet to 8 (+100)
Anthony Dabbundo
Last 30d: 49-64-0 (-12.1u)
Under 9-115
1.15u
Matt Trollo
Last 30d: 14-15-1 (+2.1u)
F.Griffin o4.5 Ks+100
0.5u
(Price offered on NOVIG, not yet accepted, would play -110 on B365 too) Has only hit this # 2 of L10, BUT proj CWS LU avg 26.2 K% v LHP.
Grant Neiffer
Last 30d: 18-75-3 (-4.6u)
M.Murakami o0.5 HR+380
0.25u
The Degenerates
Last 30d: 73-67-1 (-0.3u)
CLE -130
1u
Kyle Murray
Last 30d: 154-155-7 (+13.3u)
Under 8.5+100
1u
Allan Lem
Last 30d: 52-40-0 (+1.0u)
Under 9-119
0.6u
Topper
Last 30d: 106-88-4 (+4.4u)
Over 9+100
1u
Wind Blown Overs (***)
Overall: 362-229-26,61% (ROI:18%)
Season:15-15-1,50% (ROI:-4%)
#TSA
Matthew Lopes
Last 30d: 0-0-0 (+0.0u)
M.Vargas To Hit 1+ Home Runs Yes+456
1u
R.Grichuk To Hit 1+ Home Runs Yes+567
1u
White Sox vs. Guardians Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
White Sox vs. Guardians Public Betting Percentages
Betting Trends
- Guardians are 3-2 in their last 5 games.
- Guardians are 4-1 in their last 5 games against the spread
- Guardians are 43-38 in their road games against the spread
- The totals have gone OVER in 2 of Guardians' last 5 games
- The totals have gone OVER in 42 of Guardians' 81 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Guardians vs. White Sox Injury Updates
Guardians Injuries
White Sox Injuries
- Mike VasilRP
Vasil is out with elbow
Out
- Ky BushP
Bush is out with elbow
Out
- Brooks BaldwinLF
Baldwin is out with elbow
Out
- Drew ThorpeSP
Thorpe is out with elbow
Out
White Sox vs. Guardians Box Score
White Sox Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
 | 27 | 0.2 | 0 | 3 | |
 | 71 | 5.1 | 0 | 1 | |
 | 10 | 1 | 0 | 0 | |
 | 27 | 1.2 | 2 | 2 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
 | 2-5 | 1 | 0 | 1 |
 | 1-4 | 0 | 0 | 1 |
 | 1-3 | 0 | 0 | 3 |
 | 0-4 | 0 | 0 | 0 |
 | 2-3 | 1 | 0 | 0 |
 | 0-2 | 0 | 0 | 0 |
| 0-2 | 0 | 0 | 0 |
 | 2-4 | 1 | 0 | 1 |
 | 0-2 | 0 | 0 | 0 |
 | 0-0 | 1 | 0 | 0 |
| 0-0 | 1 | 0 | 0 |
 | 0-1 | 0 | 0 | 0 |
 | 0-2 | 0 | 0 | 0 |
| 0-2 | 0 | 0 | 0 |
 | 0-2 | 2 | 0 | 0 |
| 0-2 | 2 | 0 | 0 |
Guardians Player Stats| PITCHER | PC | IP | K | ER | |
|---|---|---|---|---|---|
 | 83 | 4 | 5 | 2 | |
 | 21 | 1 | 2 | 0 | |
 | 20 | 0.1 | 0 | 3 | |
 | 20 | 1 | 2 | 1 | |
 | 24 | 1 | 2 | 0 | |
 | 16 | 1.2 | 1 | 0 |
| HITTERS | H-AB | R | HR | RBI |
|---|---|---|---|---|
 | 1-3 | 1 | 0 | 0 |
 | 0-4 | 0 | 0 | 0 |
 | 1-4 | 1 | 1 | 2 |
 | 2-4 | 2 | 2 | 2 |
 | 2-4 | 0 | 0 | 0 |
 | 0-0 | 1 | 0 | 0 |
 | 0-4 | 0 | 0 | 0 |
 | 0-3 | 0 | 0 | 0 |
 | 0-0 | 1 | 0 | 0 |
 | 0-4 | 0 | 0 | 0 |
 | 2-3 | 1 | 0 | 2 |
White Sox vs. Guardians Odds Comparison
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White Sox at Guardians Team Totals
MatchupOverUnder | ||
|---|---|---|
White Sox 4-3 | N/A | N/A |
Guardians 5-6 | N/A | N/A |