The Cleveland Guardians host the Chicago White Sox on September 15, 2026. First pitch from Progressive Field is scheduled for 6:40 p.m. EDT. The game will be broadcast on CHSN.
The Guardians are favored by -150 on the moneyline and by -1.5 on the run line. The White Sox are +125 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.
Find my MLB picks and White Sox vs Guardians prediction below, as well as probable pitchers, weather report, and more.
White Sox vs Guardians Prediction
- White Sox vs Guardians Pick: F5 Over 4.5 (-125)
My White Sox vs Guardians best bet is on the over total runs after the first five innings. Make sure to find the best odds by checking our live MLB odds page and download the Action Network app for more picks and analysis.
White Sox vs Guardians Odds
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -170 | 8.5 -110o / -110u | +125 |
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +145 | 8.5 -110o / -110u | -150 |
- White Sox vs Guardians moneyline: White Sox +125, Guardians -150
- White Sox vs Guardians over/under: 8.5 (-110o / -110u)
- White Sox vs Guardians spread: Guardians -1.5 (+145), White Sox +1.5 (-170)
White Sox vs Guardians Probable Pitchers
| Davis Martin (RHP, CHW) | Stat | Foster Griffin (LHP, CLE) |
|---|---|---|
| 9-7 | W-L | 15-5 |
| 2.5 | fWAR (FanGraphs) | 2.2 |
| 4.05/4.71 | ERA / xERA | 3.65/4.36 |
| 3.78/4.13 | FIP / xFIP | 4.11/3.85 |
| 12.8% | K-BB% | 15.3% |
| 41.8% | GB% | 44.6% |
| .313 | BABIP | .278 |
| 90 | Stuff+ | 97 |
| 94 | Location+ | 102 |
White Sox vs Guardians MLB Betting Preview
We have winds blowing out in Cleveland with two vulnerable pitchers. It's a strong spot for the offenses.
Foster Griffin has fallen off a cliff since coming to the Guardians. It's a 5.94 ERA, 5.18 xERA, and 4.45 SIERA. His SwStr% has tumbled to 7.3%. Griffin faces a White Sox offense that leads the league in wRC+ against LHP since the start of August.
Davis Martin has survived 2 starts since returning, but he still has the same issues he faced before going on the IL. He's not missing any bats and is getting hit really hard.
Martin has permitted a 46% hard-hit rate and an average exit velocity of 92.5 mph. Somehow that's translated to a .235 BABIP.
Martin has an 0.84 ERA but a 5.46 xFIP and 5.80 SIERA in these 2 starts. The Guardians have a ton of lefties to throw at him.
Pick: F5 Over 4.5 (-125)
