White Sox vs Guardians Odds: Moneyline, Over/Under, Props - September 16, 2026 | The Action Network

White Sox at Guardians

5:10 pm • ESPN

Chicago White Sox

3

3 - 6

Cleveland Guardians

6

pitcher		team	era	w-l
P.Messick			2.56	12-9
A.Kay			4.44	10-9

MatchupOpenSpreadTotalMoneyline
White Sox 4-3	+1.5	+1.5-172	o7-102	+135
Guardians 5-6	u7.5	-1.5+137	u7-117	-161

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Wednesday 5:10 p.m.

September 16, 2026

Progressive FieldCleveland

CWS +1-115

2u

P.Messick o5.5 Ks-140

0.5u

(B365) 23.5 K% v LHB/26.9% v RHB. Proj 8/16. First 24 CWS proj. LU avg 23.4 K% v LHP. Park/ump/weather 7% boost.

Our 4 MLB Best Bets for Wednesday
Action Network Staff•
Sep 16, 2026 UTC
White Sox vs Guardians: Target This Prop in Wednesday's Matinee
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MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 4-1 in their last 5 games against the spread
Guardians are 43-38 in their road games against the spread
The totals have gone OVER in 2 of Guardians' last 5 games
The totals have gone OVER in 42 of Guardians' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	79-83	36-45	43-38	43-55	36-24
White Sox	92-70	49-32	43-38	28-23	63-46

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	77-85	42-39	35-46	48-50	27-33
White Sox	92-69-1	45-35-1	47-34	27-23-1	63-46

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	85-77	41-40	44-37	55-43	30-30
White Sox	84-78	48-33	36-45	30-21	53-56

date	opponent	score	spread	over/under	moneyline
Sep 15th	CWS	W 7-6	-1.5 L	O 9	CLE -160
Sep 14th	CWS	L 3-7	-1.5 L	O 7	CWS -182
Sep 13th	@MIN	W 9-2	+1.5 W	O 8	CLE +105
Sep 12th	@MIN	L 3-4	-1.5 L	U 8.5	MIN -109
Sep 12th	@MIN	W 5-2	-1.5 W	U 7.5	CLE -119

Mike Vasil
RP
Vasil is out with elbow
Out
Ky Bush
P
Bush is out with elbow
Out
Brooks Baldwin
LF
Baldwin is out with elbow
Out
Drew Thorpe
SP
Thorpe is out with elbow
Out

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PITCHER		PC	IP	K	ER
LA.Kay, P		66	4	3	0
LH.Smith, P		30	1.2	2	2
LS.Newcomb, P		20	0	0	2
RJ.Hicks, P		6	0.1	1	0
LN.Schultz, P		18	2	0	0

HITTERS	H-AB	R	HR	RBI
1C.Meidroth, 2B	3-5	1	0	0
1C.Meidroth, SS	3-5	1	0	0
2R.Grichuk, LF	2-5	1	0	0
3M.Vargas, 1B	1-4	0	0	0
3M.Vargas, 3B	1-4	0	0	0
4T.Pham, DH	1-4	1	1	3
5K.Teel, C	0-3	0	0	0
6B.Doyle, CF	1-4	0	0	0
7C.Montgomery, 3B	0-1	0	0	0
7M.Murakami, 1B	0-1	0	0	0
8L.Acuna, SS	0-3	0	0	0
8S.Antonacci, PH	0-1	0	0	0
8S.Antonacci, 2B	0-1	0	0	0
9T.Peters, RF	0-4	0	0	0

PITCHER		PC	IP	K	ER
LP.Messick, P		86	6	8	3
RH.Gaddis, P		16	1	0	0
LE.Sabrowski, P		19	0.2	0	0
RC.Smith, P		15	1.1	2	0

HITTERS	H-AB	R	HR	RBI
1S.Kwan, LF	0-3	1	0	0
2J.Ramirez, 3B	2-4	0	0	1
3J.Adell, RF	1-3	0	0	2
4T.Bazzana, DH	0-4	0	0	0
5D.Fry, 1B	0-3	1	0	0
5N.Lowe, 1B	0-0	0	0	0
6A.Genao, 2B	0-3	0	0	0
7A.Hedges, C	0-3	1	0	0
8P.Halpin, CF	2-4	2	1	3
9B.Rocchio, SS	0-3	1	0	0

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MatchupOverUnder
White Sox 4-3	N/A	N/A
Guardians 5-6	N/A	N/A