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White Sox vs. Guardians Odds & Betting Predictions - September 16, 2026

White Sox at Guardians

5:10 pm • ESPN

Chicago White Sox

77-74
@

Cleveland Guardians

77-75
Starting Pitchers
pitcherteameraw-l
Parker Messick logoP.MessickCleveland Guardians logo2.5111-9
Anthony Kay logoA.KayChicago White Sox logo4.539-9

White Sox at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
White Sox
77-74
+1.5
+1.5-150
o8-112
+145
Guardians
77-75
u7.5
-1.5+125
u8-107
-176
location pinWednesday 5:10 p.m.
September 16, 2026
Progressive FieldCleveland
thermometer image79°Fahrenheit
rain image12%Rain
wind image6Wind
White Sox vs. Guardians Expert Picks
Matt Trollo
Matt Trollo
Last 30d: 56-72-2 (-16.1u)
P.Messick o5.5 Ks-140
0.7u
(B365) 23.5 K% v LHB/26.9% v RHB. Proj 8/16. First 24 CWS proj. LU avg 23.4 K% v LHP. Park/ump/weather 7% boost.

Prop Odds Comparison

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Line Movement Tracker

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White Sox vs. Guardians Public Betting Percentages

Away Logo

White Sox

Public

Home Logo

Guardians

28%

Bets%

72%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Guardians are 3-2 in their last 5 games.
  • Guardians are 2-3 in their last 5 games against the spread
  • Guardians are 39-36 in their road games against the spread
  • The totals have gone OVER in 3 of Guardians' last 5 games
  • The totals have gone OVER in 40 of Guardians' 77 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians		72-8033-4439-3638-5434-22
White Sox		85-6644-3041-3621-2063-45

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians		73-7940-3733-4244-4827-29
White Sox		85-65-142-31-143-3421-19-162-46

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians		77-7537-4040-3549-4328-28
White Sox		77-7443-3134-4323-1853-55

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 15thCWSW 7-6-1.5 LO 9CLE -160
Sep 14thCWSL 3-7-1.5 LO 7CWS -182
Sep 13th@MINW 9-2+1.5 WO 8CLE +105
Sep 12th@MINL 3-4-1.5 LU 8.5MIN -109
Sep 12th@MINW 5-2-1.5 WU 7.5CLE -119

Guardians vs. White Sox Injury Updates

Guardians Injuries

    White Sox Injuries

    • Mike Vasil
      RP

      Vasil is out with elbow

      Out

    • Ky Bush
      SP

      Bush is out with elbow

      Out

    • Brooks Baldwin
      LF

      Baldwin is out with elbow

      Out

    • Drew Thorpe
      SP

      Thorpe is out with elbow

      Out

    See more MLB Injuries Right Arrow
    White Sox vs. Guardians Starting Lineups
    White Sox Starting Lineup
    Projected
    PITCHERW-LERAWHIPK/9
    Erick Fedde logoRE.Fedde, P8-93.971.3396.13
    HITTERSAVGOBPSLGHR
    Chase Meidroth logo1C.Meidroth, 2B.268.344.39914
    Randal Grichuk logo2R.Grichuk, LF.194.212.3230
    Miguel Vargas logo3M.Vargas, 3B.249.358.47531
    Munetaka Murakami logo4M.Murakami, 1B.202.344.46031
    Edgar Quero logo5E.Quero, C.203.284.2573
    Brenton Doyle logo6B.Doyle, CF.230.230.3772
    Braden Montgomery logo7B.Montgomery, RF.210.307.3386
    Jake Rogers logo8J.Rogers, DH.200.333.2000
    Luisangel Acuna logo9L.Acuna, SS.234.268.2691
    Guardians Starting Lineup
    Projected
    PITCHERW-LERAWHIPK/9
    Parker Messick logoLP.Messick, P11-92.511.0339.30
    HITTERSAVGOBPSLGHR
    Steven Kwan logo1S.Kwan, CF.279.376.3463
    Jose Ramirez logo2J.Ramirez, 3B.228.317.35911
    Chase DeLauter logo3C.DeLauter, RF.289.362.45314
    Jo Adell logo4J.Adell, LF.239.313.4306
    Travis Bazzana logo5T.Bazzana, DH.252.344.41214
    Nathaniel Lowe logo6N.Lowe, 1B.231.280.4025
    Angel Genao logo7A.Genao, 2B.228.290.3162
    Austin Hedges logo8A.Hedges, C.255.326.3755
    Brayan Rocchio logo9B.Rocchio, SS.249.309.37713

    White Sox vs. Guardians Odds Comparison

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    White Sox at Guardians Team Totals

    MatchupOverUnder
    White Sox
    77-74
    N/A
    N/A
    Guardians
    77-75
    N/A
    N/A