Read below for our 4 MLB Best Bets Today, including picks for Guardians vs White Sox (1:00 PM ET, Rate Field) and Phillies vs Nationals (6:45 PM ET, Nationals Park).
MLB Best Bets Today
The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 1:00 PM | |
  | 1:40 PM | |
  | 6:45 PM | |
  | 9:40 PM | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Action PRO's White Sox vs Guardians Best Bet
By Action PRO
Action PRO projects Parker Messick to record 6.85 strikeouts, yielding an immediate value edge against the current 6.5 line.
Messick has been exceptionally comfortable against this Chicago lineup, dominating them across three prior outings this season with a pristine 2.29 ERA and 21 strikeouts over 19.2 innings.
His overall form remains sharp as the season winds down, demonstrated by a massive 12-strikeout display against the Detroit Tigers on September 5.
Messick has eclipsed his strikeout projection in 7 of his last 10 starts. Even with a minor cool-down during three of his last four appearances, his overall swing-and-miss stuff makes Over 6.5 Strikeouts the top play for Wednesday's divisional finale.
Pick: Parker Messick Over 6.5 Strikeouts (-110 or Better)
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Ryan Minion's Yankees vs Twins Best Bet
By Ryan Minion
The Twins and Yankees will square off on Wednesday afternoon in another spot where I heavily favor targeting player prop markets.
33-year-old veteran left-hander Carlos Rodon will get the start for New York, while righty Zebby Matthews will take the mound for the Twins.
In what has been an up-and-down 2026 campaign for Minnesota’s right-hander, with Matthews currently posting a 4.98 ERA so far, I expect this to be another tough challenge against a red-hot Yankee lineup.
In this case, I expect the Yankees’ lefty slugger Ben Rice to have a monster day at the plate versus the Twins’ 26-year-old.
In eight previous encounters between the two, New York’s 27-year-old has recorded four hits – two of which were for extra bases, with a double and a home run.
The Yankees’ youngster put on a ton of muscle in the offseason and has quickly established himself as one of baseball’s premier power hitters — ranking seventh in all of baseball with 38 HRs in 2026 thus far.
Matthews has struggled to keep the ball in the yard for most of the season, allowing 23 homers in fewer than 120 frames on the mound.
I expect this to be a highly favorable matchup for Rice given his remarkably impressive pull-heavy left-handed power bat.
New York’s Designated Hitter is also on an absolute tear right now, so he enters Wednesday’s contest in phenomenal form.
That said, I favor backing Rice to exceed an alternate 2.5 HRR total as my primary betting angle ahead of Wednesday’s American League showdown.
As a secondary wager, I'm willing to take a shot on the Yankees moneyline as well given their far superior lineup and a rather significant edge on the mound on Wednesday afternoon.
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Picks: Ben Rice Over 2.5 HRR (+125 or Better) | Yankees ML (-150 or Better)
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Derek Carty's Phillies vs Nationals Best Bet
By Derek Carty
THE BAT X is forecasting 0.50 walks for Brandon Marsh. Oddsmakers are implying 0.30 walks, so I believe there is value on this prop.
If you take the over, you'd be projected to win 41% of the time, for a 54% ROI and an expected value of $54.20 (based on a $100 wager).
This play is good down to at least +171.
Love THE BAT X? Get all of Carty’s sports betting projections at EV Analytics!
Pick: Brandon Marsh Over 0.5 Walks (+171 or Better)
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Tanner McGrath's Marlins vs Diamondbacks Best Bet
Our own Sean Zerillo projects some value on the Diamondbacks ML in this game.
If you'd like to dive deeper into the matchup, we reccomend checking out BARTOLO, our new PRO baseball betting tool giving Action PRO Subscribers access to all the live data and stats we use to project MLB games every day.
Here's a sneak peek at what BARTOLO can provide for this game:
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Pick: Diamondbacks ML (-140 or Better)
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