The Detroit Tigers host the Athletics on Wednesday, June 25, 2025. First pitch from Comerica Park is scheduled for 6:40 p.m. ET; the game will be broadcast on FDSDET and MLB.TV.
The Tigers enter as -173 favorites on the moneyline, while the Athletics come in at +145 to pull off the upset. The over/under, meanwhile, sits at 8.
Find my Athletics vs Tigers prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports and more.
Athletics vs Tigers Prediction
- Athletics vs. Tigers Pick: Jacob Lopez Over 4.5 Strikeouts (-150)
My Tigers vs. Athletics best bet is on A's starter Jacob Lopez to go over his strikeout total. Make sure to find the best odds by checking our live MLB odds page.
Athletics vs Tigers Odds
| Athletics Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
+1.5 -152 | 8 -120o / +100u | +145 |
| Tigers Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
-1.5 +125 | 8 -120o / +100u | -173 |
Athletics vs Tigers Projected Starting Pitchers
Athletics vs Tigers MLB Betting Preview
For Wednesday’s matchup between the Athletics and Tigers, one of the top picks from PRO Projections is betting on Athletics starter Jacob Lopez to go over his strikeout total.
Although the over is priced a bit steep at -150, it remains one of the strongest betting edges according to our proprietary MLB data, which combines expert analysis, player projections, and odds comparisons to identify value in the markets.
Lopez’s strikeout over/under is set at 4.5 for the second game of the series. PRO projections have him surpassing that mark comfortably with an expected 5.8 strikeouts.
Lopez has been dominant on the mound recently, delivering back-to-back starts with six innings and nine strikeouts. In fact, he has struck out at least five batters in three consecutive outings.
Athletics vs Tigers Prediction, Betting Analysis
While Detroit is regarded as one of the better offensive teams in the league, it ranks ninth in baseball for most team strikeouts per game, which plays into Lopez’s favor.
Additionally, the venue provides a significant advantage for Lopez’s strikeout potential. Comerica Park ranks seventh among parks for adjusted strikeouts, whereas his home ballpark, Sutter Health Park, is among the least favorable for striking out batters.
This environmental boost further supports taking Lopez over the strikeout total in Wednesday’s contest.
Pick: Jacob Lopez Over 4.5 Strikeouts (-150)
Moneyline
I don't have a bet on the moneyline for Wednesday's game between the Athletics and Tigers.
Run Line (Spread)
Like the moneyline, I'm staying away from betting the run line in this game.
Over/Under
While I don't have a bet on the full-game total, my best bet for this matchup is for A's starting pitcher Jacob Lopez to go over his strikeout total.
