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Diamondbacks vs Rockies Prediction, Pick, MLB Odds for Tuesday, September 22

Diamondbacks vs Rockies Prediction, Pick, MLB Odds for Tuesday, September 22 article feature image
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Robert Edwards-Imagn Images. Pictured: Kyle Freeland.

The Colorado Rockies host the Arizona Diamondbacks on September 22, 2026. First pitch from Coors Field is scheduled for 8:40 p.m. EDT. The game will be broadcast on ARID.

The Diamondbacks are favored by -196 on the moneyline and by -1.5 on the run line. The Rockies are +163 on the moneyline and +1.5 on the run line. The total is set at 11 runs.

Find my MLB picks and Diamondbacks vs Rockies prediction below, as well as probable pitchers, weather report, and more.


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Diamondbacks vs Rockies Prediction

My Diamondbacks vs Rockies best bet is on game totals. Make sure to find the best odds by checking our live MLB odds page.


Diamondbacks vs Rockies Odds

Diamondbacks Logo
September 22, 2026
8:40 p.m. EDT
ARID
Rockies Logo
Diamondbacks Odds
SpreadTotalMoneyline
-1.5
+105
11
-100o / -115u
-196
Rockies Odds
SpreadTotalMoneyline
+1.5
-125
11
-100o / -115u
+163
Odds via DraftKings. Get up-to-the-minute MLB odds here.
DraftKings Logo
  • Diamondbacks vs Rockies moneyline: Diamondbacks -196, Rockies +163
  • Diamondbacks vs Rockies over/under: 11 (-100o / -115u)
  • Diamondbacks vs Rockies spread: Diamondbacks -1.5 (-125), Rockies +1.5 (+105)

Diamondbacks vs Rockies Probable Pitchers

Michael Soroka (RHP, ARI)StatKyle Freeland (LHP, COL)
8-5W-L4-10
2.6fWAR (FanGraphs)0.9
3.45 / 4.21ERA / xERA6.38 / 5.32
3.08 / 3.67FIP / xFIP5.01 / 4.25
17.5%K-BB%13.2%
37.1%GB%40.8%
.292BABIP.328
94Stuff+90
105Location+103

Diamondbacks vs Rockies MLB Betting Preview

Looking at Sean Zerillo’s BARTOLO tool in the Action Network app, the single biggest edge on the entire board tonight is the Under 11 in Arizona vs. Colorado.

Sure, it's a sky-high total at Coors Field. We have wind blowing out to right field, but it’s fall now, and the weather is starting to cool down in Denver. Sportsbooks have juiced this total up a bit too high despite the venue, the return of Michael Soroka, and the Kyle Freeland factor.

From an anecdotal standpoint, you have to wonder how motivated this Arizona team is going to be. They’ve been grinding all September, but their playoff hopes are essentially dead and they're virtually eliminated. Books are also overreacting to how well Arizona hits lefties — they project at a solid 118 wRC+ against southpaws, but Soroka can hold down Colorado's offense on his end.

Beyond that, people haven't realized how sneaky good Arizona's bullpen has been late this season with Justin Martinez back alongside Brandon Garcia, Juan Morillo, Jonathan Loaisiga, and Kevin Ginkel.

BARTOLO gives us a massive edge here at Coors, but if you want some extra value, you can do a little correlated SGP: Under 11 + Kyle Freeland Under 5.5 Hits Allowed (-103). I think that pays out about +170 at DraftKings as well.

Pick: Under 11


Diamondbacks vs Rockies Weather


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About the Author

Collin Whitchurch is the manager of cross-platform content at Action Network, working directly with on-air talent, editors, and producers on efficient prioritization of coverage across the editorial, video, and audio mediums. Prior to his current role, Collin was the senior MLB editor at Action, managing the day-to-day content produced about baseball.

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