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The Boston Red Sox host the Chicago Cubs on September 25, 2026. First pitch from Fenway Park is scheduled for 5:35 p.m. EDT. The game will be broadcast on MARQ.
The Cubs are favored by -115 on the moneyline and by -1.5 on the run line. The Red Sox are -105 on the moneyline and +1.5 on the run line. The total is set at 6.5 runs.
Find my MLB picks and Cubs vs Red Sox prediction below, as well as probable pitchers, weather report, and more.
Cubs vs Red Sox Prediction
- Cubs vs Red Sox Pick: Wilyer Abreu 1+ Home Run (+1000, FanDuel– Play to +796)
My Cubs vs Red Sox best bet is on Wilyer Abreu to hit at least one home run. Make sure to find the best odds by checking our live MLB odds page. Be sure to download the Action Network app for more picks and analysis.
Cubs vs Red Sox Odds
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -185 | 6.5 -102o / -118u | -115 |
| Red Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 +150 | 6.5 -102o / -118u | -105 |
- Cubs vs Red Sox moneyline: Cubs -115, Red Sox -105
- Cubs vs Red Sox over/under: 6.5 (-102o / -118u)
- Cubs vs Red Sox spread: Cubs -1.5 (+150), Red Sox +1.5 (-185)
Cubs vs Red Sox Probable Pitchers
| David Peterson (LHP, CHC) | Stat | Brayan Bello (RHP, BOS) |
|---|---|---|
| 9-8 | W-L | 6-7 |
| 1.5 | fWAR (FanGraphs) | 0.9 |
| 4.96/4.76 | ERA / xERA | 4.49/4.96 |
| 4.03/3.95 | FIP / xFIP | 4.00/3.84 |
| 10.6% | K-BB% | 11.3% |
| 50.5% | GB% | 53.3% |
| .323 | BABIP | .311 |
| 89 | Stuff+ | 93 |
| 101 | Location+ | 107 |
Cubs vs Red Sox Pick, Betting Analysis
By Derek Carty
I am looking at Wilyer Abreu to hit a home run in Game 2 of the doubleheader. You can get this at +1050 at Fanatics, with +1000 available at FanDuel, and I like it down to +800.
The situation in Boston is not great because there is heavy wind blowing in, but Fenway Park is still a really favorable ballpark for power. Facing Cubs southpaw David Peterson, Abreu is going to have the platoon advantage. Peterson can certainly give up home runs, and THE BAT X model has Abreu hitting a home run about 12% of the time in this matchup.
That projects to offer us really good value at the number books are laying here.
Pick: Wilyer Abreu 1+ Home Run (+1000, FanDuel– Play to +796)
