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Reds vs Blue Jays Prediction, Pick, MLB Odds for Friday, September 25

Reds vs Blue Jays Prediction, Pick, MLB Odds for Friday, September 25 article feature image
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Jayne Kamin-Oncea-Imagn Images. Pictured: Reds SP Nick Lodolo

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The Toronto Blue Jays host the Cincinnati Reds on September 25, 2026. First pitch from Rogers Centre is scheduled for 7:07 p.m. ET. The game will be broadcast on SNET.

The Blue Jays are favored by -136 on the moneyline and by -1.5 on the run line. The Reds are +113 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.

Find my MLB picks and Reds vs. Blue Jays prediction below, as well as probable pitchers, weather report, and more.


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Reds vs Blue Jays Prediction

  • Reds vs Blue Jays Pick: Nick Lodolo Under 4.5 Strikeouts (-136)

My Reds vs Blue Jays best bet is on the Cincinnati starter to record four or fewer strikeouts in this game. Make sure to find the best odds by checking our live MLB odds page, and download the Action Network app for more picks and analysis.


Reds vs Blue Jays Odds

Reds Logo
Friday, Sep 25
7:07 p.m. ET
SNET
Blue Jays Logo
Reds Odds
SpreadTotalMoneyline
+1.5
-193
7.5
-115o / -105u
+113
Blue Jays Odds
SpreadTotalMoneyline
-1.5
+159
7.5
-115o / -105u
-136
Odds via DraftKings. Get up-to-the-minute MLB odds here.
DraftKings Logo
  • Reds vs Blue Jays moneyline: Reds +113, Blue Jays -136
  • Reds vs Blue Jays over/under: 7.5 (-115o / -105u)
  • Reds vs Blue Jays spread: Reds +1.5 (-193), Blue Jays -1.5 (+159)

Reds vs Blue Jays Probable Pitchers

Nick Lodolo (LHP, CIN)StatJose Soriano (RHP, TOR)
3-6W-L12-8
-0.2fWAR (FanGraphs)2.6
5.04 / 6.41ERA / xERA3.72 / 4.37
5.77 / 4.93FIP / xFIP3.86 /3.73
7.8K-BB%12.9
41.3GB%53.2
.290BABIP.281
105Stuff+97
89Location+106

Reds vs Blue Jays MLB Betting Preview

Action PRO projects Nick Lodolo for 3.45 strikeouts today against the Blue Jays, giving us a solid 15.9% edge when compared to his current prop line of over/under 4.5, which is good enough to tag the under with an A- grade in our system.

It's his final start of the season, and he's coming off a game against the Cubs in which he struck out just one batter in seven complete frames.

The Reds starter has only 16 Ks this month in 24 2/3 innings and will face a Toronto lineup with the second-lowest strikeout rate in MLB at 19.0%.


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Reds vs Blue Jays Pick, Betting Analysis

Lodolo has been under this line in six of his past 10 starts, never reaching more than six Ks in that span.

Let's fade him tonight against Toronto.

Pick: Nick Lodolo Under 4.5 Strikeouts (-136, DraftKings)


Reds vs Blue Jays Weather


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