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Orioles vs Yankees Game 1 Prediction, Pick, MLB Odds for Friday, September 25

Orioles vs Yankees Game 1 Prediction, Pick, MLB Odds for Friday, September 25 article feature image
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Vincent Carchietta-Imagn Images. Pictured: Orioles 1B Pete Alonso

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The New York Yankees host the Baltimore Orioles on September 25, 2026. First pitch from Yankee Stadium is scheduled for 4:05 p.m. ET. The game will be broadcast on FOX.

Find my MLB picks and Orioles vs Yankees prediction below, as well as probable pitchers, weather report, and more.


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Orioles vs Yankees Prediction

  • Orioles vs Yankees Pick: Pete Alonso Home Run (+390)

My Orioles vs Yankees best bet is on Pete Alonso to hit a homer this afternoon. Make sure to find the best odds by checking our live MLB odds page, and download the Action Network app for more picks and analysis.


Orioles vs Yankees Probable Pitchers

Brandon Young (RHP, BAL)StatMichael Fulmer (LHP, NYY)
9-5W-L0-1
1.4fWAR (FanGraphs)0.0
3.62 / 4.31ERA / xERA3.29 / 3.76
4.53 / 4.46FIP / xFIP4.34 / 3.98
10.6K-BB%16.4
42.6GB%38.2
.287BABIP.281
97Stuff+101
105Location+91

Orioles vs Yankees MLB Betting Preview, Prediction

This isn't a bad spot, and these odds are a bit too high for Orioles slugger Pete Alonso.

It looks like Michael Fulmer will open for the Yankees, and Will Warren could come in as a long reliever.

Fulmer is a slightly below-average matchup for righty power, while Warren is an above-average matchup (1.34 HR/9 this season).

The weather has heavy winds, but they're crossing and shouldn't affect power much.

I have the true odds for Alonso at around +350.

Pick: Pete Alonso Home Run (+390, FanDuel)


Orioles vs Yankees Weather


Get the latest coverage on MLB Weather.


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About the Author
Grant Neiffer • Verified Action Expert

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