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Dodgers vs Giants Prediction, Pick, MLB Odds for Friday, September 25

Dodgers vs Giants Prediction, Pick, MLB Odds for Friday, September 25 article feature image
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IMAGN IMAGES via Reuters Connect. Pictured: Los Angeles Dodgers shortstop Mookie Betts

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The San Francisco Giants host the Los Angeles Dodgers on September 25, 2026. First pitch from Oracle Park is scheduled for 10:15 p.m. EDT. The game will be broadcast on SportsNet LA.

The Dodgers are favored by -338 on the moneyline and by -1.5 on the run line. The Giants are +267 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.

Find my MLB picks and Dodgers vs Giants prediction below, as well as probable pitchers, weather report, and more.


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Dodgers vs Giants Prediction

  • Dodgers vs Giants Pick: Mookie Betts Over 1.5 Hits (+193, DraftKings)

My Dodgers vs Giants best bet is on Mookie Betts to go over his props/batting" target="_blank" rel="noopener">hits total. Make sure to find the best odds by checking our live MLB odds page.


Dodgers vs Giants Odds

Dodgers Logo
September 25, 2026
10:15 p.m. EDT
SportsNet LA
Giants Logo
Dodgers Odds
SpreadTotalMoneyline
-1.5
+150
7.5
-100o / -120u
-338
Giants Odds
SpreadTotalMoneyline
+1.5
-176
7.5
-100o / -120u
+267
Odds via BetMGM. Get up-to-the-minute MLB odds here.
BetMGM Logo
  • Dodgers vs Giants moneyline: Dodgers -338, Giants +267
  • Dodgers vs Giants over/under: 7.5 (-100o / -120u)
  • Dodgers vs Giants spread: Dodgers -1.5 (-176), Giants +1.5 (+150)

Dodgers vs Giants Probable Pitchers

Tarik Skubal (LHP, LAD)StatYunior Marte (RHP, SFG)
11-7W-L0-0
4.7fWAR (FanGraphs)0.0
2.85/3.06ERA / xERA4.66/4.85
2.61/2.74FIP / xFIP5.37/5.38
25.0%K-BB%2.4%
43.5%GB%38.7%
.291BABIP.250
117Stuff+85
105Location+96

Dodgers vs Giants MLB Betting Preview

The Los Angeles Dodgers (97-62) enter the final stretch of the regular season looking to keep momentum high as they tune up for another postseason run. Los Angeles boasts one of the most explosive lineups in baseball, led by top-of-the-order firepower that consistently puts pressure on opposing pitching staffs from the very first pitch.
Left-hander Tarik Skubal (11-7, 2.84 ERA) gets the ball for the Dodgers as they look to assert dominance early on the road.

The San Francisco Giants (65-94) are wrapping up a challenging campaign and looking to play spoiler against their chief rivals.

San Francisco's pitching staff faces a tall task, initiating a bullpen game or leaning on depth arms like right-hander Yunior Marte. The Giants' staff has struggled down the stretch against high-contact, high-OBP top-of-the-order hitters, making this matchup particularly challenging against the Dodgers' core.


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Dodgers vs Giants Pick, Betting Analysis

According to PRO Projections, one of the top edge props on Friday's MLB slate is Mookie Betts Over 1.5 Hits.

Betts has been locked in at the plate down the stretch. In his recent outings against San Francisco, Betts has consistently barreled up Giants pitching, including a multi-hit performance (4-for-4) during their prior series. Over his last several starts, Betts has produced multiple multi-hit games, highlighting a hot streak at the ideal time.

With the Giants relying on dynamic bullpen setups and hittable depth options, Betts gets a direct advantage. As the Dodgers' premier top-of-the-order bat, Betts typically sees 4 to 5 plate appearances per game, giving him maximum opportunities to stack hits against weak coverage.

Betts continues to feature elite contact metrics with low strikeout rates and high-percentage hard-hit rates. His ability to drive line drives across all fields at Oracle Park plays exceptionally well against San Francisco's defensive alignments.

Pick: Mookie Betts Over 1.5 Hits (+193, DraftKings)


Dodgers vs Giants Weather


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