The St. Louis Cardinals host the Chicago Cubs on June 24, 2025. First pitch from Busch Stadium is scheduled for 7:45 p.m. EDT; the game will be broadcast on MARQ.
The Cubs dropped a game in the NL Central race on Monday, and their previously comfortable lead could shrink to 0.5 games if the Cardinals sweep.
The Cubs enter as -115 road favorites with an 8.5-run total.
Find my MLB betting preview and Cubs vs Cardinals prediction below, as well as probable pitchers, betting trends, injury reports and more.
My Cubs vs Cardinals Prediction
- Cubs vs Cardinals picks: Cubs ML (-130 or better)
My Cubs vs Cardinals best bet is on Chicago ML. Make sure to find the best odds by checking our live MLB odds page.
Cubs vs Cardinals Odds & Game Information
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +135 | 9 -110o / -110u | -120 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -160 | 9 -110o / -110u | +100 |
Cubs vs Cardinals Probable Pitchers
| RHP Jameson Taillon (CHC) | Stat | RHP Michael McGreevy (STL) |
|---|---|---|
| 7-4 | W-L | 1-1 |
| 0.5 | fWAR (FanGraphs) | 0.6 |
| 3.84 / 4.06 | ERA / xERA | 2.70 / 3.82 |
| 4.82 / 4.05 | FIP / xFIP | 2.59 / 3.41 |
| 1.04 | WHIP | 0.84 |
| 14.5% | K-BB% | 20.0% |
| 34.1% | GB% | 36.2% |
| 96 | Stuff+ | 92 |
| 109 | Location+ | 123 |
Cubs vs Cardinals Betting Insights
Chicago Cubs Betting Preview: Taillon Looks to Regain Form on the Road
The Chicago Cubs are one of the best offensive teams in baseball.
Sure, you can look at some of the crazy Coors-esque scoring games at Wrigley Field and attribute that to the Cubs' offensive success. However, the Cubs have an .808 road OPS compared to a .730 at home.
To me, that signals the legitimacy of this offense.
In 2025, the Cubs' 116 wRC+ ranks third among MLB teams, trailing only the Dodgers and Yankees. So, you can make an argument that a 104 wRC+ through 20 games in June is relatively disappointing.
I’d be willing to bet Chicago won’t endure a worse 20-game stretch, as it ranks 29th among MLB teams in BABIP during the stretch (.253). If the batted ball luck swings in the Cubs' favor, they’ll return to being a top-five offense.
The Cubs will hand veteran right-hander Jameson Taillon the ball in the middle game versus St Louis. After Taillon’s last outing, where he allowed five runs and eight hits over four innings in a loss to Milwaukee, it’s fair to question him.
Taillon’s biggest problem is homers, as his 1.87 HR/9 allowed is a career-worst. That said, the Cardinals aren’t built to expose Taillon’s warts.
St. Louis Cardinals Betting Preview: Big Test for McGreevy
St. Louis has an offense centered around making contact.
It doesn’t hit for much power, as it ranks 19th among MLB lineups with 22 home runs and 25th with a .131 isolated power in June.
The Cardinals' team leaders in home runs are Nolan Arenado and Willson Contreras with 10. That’s a pretty low number considering it’s almost July.
That’s not even the craziest part, though. Contreras and Arenado have hit four of their 10 home runs in June, but still trail Alec Burleson, who leads the team this month, as he drilled his fifth on Monday.
That’s excellent news for St. Louis, but it’s a genuine concern to be one of the worst power-hitting teams, even with three players having four homers in one month.
After a brilliant outing from Matthew Liberatore on Monday, the Cardinals will recall former first-rounder Michael McGreevy to make Tuesday's start.
In three major-league outings this year, McGreevy has a 2.70 ERA with a 3.81 xERA in 16 2/3 innings. He was equally impressive in Triple-A, posting a 2.51 ERA with a 2.95 xERA. He features a seven-pitch mix with four of the pitches being thrown at least 10% of the time. He's not a flamethrower by any means, averaging 93 mph on his four-seamer, but the pitch mix can keep batters off balance.
McGreevy had just one bad outing this year, and it came against the Dodgers. There's no shame in struggling against the best offenses in baseball.
That said, the Cubs will pose the second-toughest test for the young right-hander.
Cubs vs Cardinals Prediction, Betting Analysis
I like the Cubs in a bounce-back spot following Monday's ugly loss.
The pitching matchup is a wash, given McGreevy's inexperience and Taillon's streaky pitching.
So, I give the Cubs offense a pretty substantial edge over the Cardinals, even with St. Louis tagging Ben Brown for eight runs and four homers.
Before Taillon's blow-up in Chicago last week, he pitched six consecutive outings with three or fewer runs, and the Cubs snagged a win in five of the six.
So, I won't fade Taillon solely off one bad outing. The bigger picture indicates Taillon can put Chicago in a good enough position to win.
Pick: Cubs ML (play to -130)
Moneyline
I like the Cubs here.
Run Line (Spread)
No play.
Over/Under
No play.
