The Arizona Diamondbacks host the Colorado Rockies on May 21, 2026. First pitch from Chase Field is scheduled for 9:40 p.m. ET. The game will be broadcast on ARID.
The Diamondbacks are favored by -198 on the moneyline and by -1.5 on the run line. The Rockies are +166 on the moneyline and +1.5 on the run line. The total is set at 9 runs.
Find our MLB picks and Rockies vs Diamondbacks prediction below, as well as probable pitchers, weather report, and more.
Rockies vs Diamondbacks Prediction
- Rockies vs Diamondbacks Pick: Eduardo Rodriguez Under 5.5 Strikeouts (-134)
Our Rockies vs Diamondbacks best bet is on Eduardo Rodriguez to record five or fewer strikeouts tonight. Make sure to find the best odds by checking our live MLB odds page.
Rockies vs Diamondbacks Odds
| Rockies Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -120 | 9 -120o / -102u | +166 |
| Diamondbacks Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +100 | 9 -120o / -102u | -198 |
- Rockies vs Diamondbacks moneyline: Rockies +166, Diamondbacks -198
- Rockies vs Diamondbacks over/under: 9 (-120o / -102u)
- Rockies vs Diamondbacks spread: Rockies +1.5 (-120), Diamondbacks -1.5 (+100)
Rockies vs Diamondbacks Probable Pitchers
| RHP Zach Agnos (COL) | Stat | LHP Eduardo Rodriguez (ARI) |
|---|---|---|
| 0-0 | W-L | 4-1 |
| 0.0 | fWAR (FanGraphs) | 0.7 |
| 5.59 / 4.48 | ERA / xERA | 2.53 / 4.48 |
| 4.21 / 4.71 | FIP / xFIP | 3.86 / 4.36 |
| 7.8 | K-BB% | 7.6 |
| 38.9 | GB% | 42.9 |
| .298 | BABIP | .259 |
| 92 | Stuff+ | 90 |
| 102 | Location+ | 107 |
Rockies vs Diamondbacks MLB Betting Preview
Action PRO projects Diamondbacks starter Eduardo Rodriguez for 4.6 strikeouts tonight against the Rockies, giving us an excellent 16.7% edge against the market when compared to his current prop line of over/under 5.5, which is good enough to tag the under with an A- grade in our system.
Rodriguez already struggled in his last outing against this same Rockies lineup, even though he racked up six Ks, and will now face them for the second time in five days.
This season, he has recorded only 39 strikeouts in 53 and 1/3 innings so far, with a 7.6 K-BB%.
Rockies vs Diamondbacks Pick, Betting Analysis
Rodriguez has been under this 5.5 line in all but two starts this season.
Following that trend, let's fade him tonight on his K's line against Colorado.
Pick: Eduardo Rodriguez Under 5.5 Strikeouts (-134, FanDuel)
