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MLB Home Run Picks Today: 6 Player Props for Dodgers vs Brewers, Rockies vs Diamondbacks, More for Friday, May 22

MLB Home Run Picks Today: 6 Player Props for Dodgers vs Brewers, Rockies vs Diamondbacks, More for Friday, May 22 article feature image
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May 20, 2026; Phoenix, Arizona, USA; Arizona Diamondbacks second baseman Ketel Marte (4) celebrates after hitting a two run home run in the third inning against the San Francisco Giants at Chase Field. Mandatory Credit: Matt Kartozian-Imagn Images

Happy Friday! Congrats on making it to the weekend.

You know I've got some bangers.

Specifically, 6 MLB home run picks today.


MLB Home Run Picks Today

GameTime (ET)Pick
Pittsburgh Pirates LogoToronto Blue Jays Logo
7:07 PM
Pittsburgh Pirates LogoToronto Blue Jays Logo
7:07 PM
Los Angeles Dodgers LogoMilwaukee Brewers Logo
7:40 PM
Los Angeles Dodgers LogoMilwaukee Brewers Logo
7:40 PM
Texas Rangers LogoLos Angeles Angels Logo
9:38 PM
Colorado Rockies LogoArizona Diamondbacks Logo
9:40 PM
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.


Pirates vs Blue Jays Prediction

Pittsburgh Pirates Logo
Friday, May 22
7:07 PM ET
MLB.TV
Toronto Blue Jays Logo
Oneil Cruz Home Run
FanDuel Logo

This is just a price play here for the Pirates' power lefties.

Gausman is a tough overall matchup and a below-average one for power, but the ballpark is a big upgrade for lefty power.

Cruz is having a bit of a breakout year, and I have the true odds around +370 today, making this a great EV bet.

Pick: Oneil Cruz Home Run



Pirates vs Blue Jays Best Bet

Pittsburgh Pirates Logo
Friday, May 22
7:07 PM ET
MLB.TV
Toronto Blue Jays Logo
Brandon Lowe Home Run
FanDuel Logo

This is just a price play here for the Pirates' power lefties.

Gausman is a tough overall matchup and a below-average one for power, but the ballpark is a big upgrade for lefty power.

Lowe has been having a career on pace for around 40 bombs this season despite the bad weather and bad ballpark.

I have the true odds on Lowe around +400, making this a great EV bet.

Pick: Brandon Lowe Home Run



Dodgers vs Brewers Prediction

Los Angeles Dodgers Logo
Friday, May 22
7:40 PM ET
MLB.TV
Milwaukee Brewers Logo
Freddie Freeman Home Run
FanDuel Logo

We don't have a large sample size for Logan Henderson in the majors, but in a small sample, he's been a massive fly-ball pitcher to lefties, giving up a 56% fly-ball rate.

He grades out as a well-above-average matchup for lefty power.

Freeman isn't the biggest power hitter, but given the great matchup, I have the true odds around +350 today, making this a great EV bet.

Pick: Freddie Freeman Home Run



Dodgers vs Brewers Best Bet

Los Angeles Dodgers Logo
Friday, May 22
7:40 PM ET
MLB.TV
Milwaukee Brewers Logo
Max Muncy Home Run
FanDuel Logo

We don't have a large sample size for Logan Henderson in the majors, but in a small sample, he's been a massive fly-ball pitcher to lefties, giving up a 56% fly-ball rate.

He grades out as a well-above-average matchup for lefty power.

Muncy has been absolutely hammering the ball this season, and I have the true odds around +300, making this a great EV bet.

Pick: Max Muncy Home Run



Rangers vs Angels Prediction

Texas Rangers Logo
Friday, May 22
9:38 PM ET
MLB.TV
Los Angeles Angels Logo
Mike Trout Home Run
FanDuel Logo

Trout has been hammering the ball this season, and while he's been a little slower lately, the underlying numbers have been some of the best of his career for power.

The matchup vs. deGrom isn't a great one overall, but he's been a plus for power since joining the Rangers.

I have the true odds around +340 today, making this a great EV bet.

Pick: Mike Trout Home Run



Rockies vs Diamondbacks Prediction

Colorado Rockies Logo
Friday, May 22
9:40 PM ET
MLB.TV
Arizona Diamondbacks Logo
Ketel Marte Home Run
FanDuel Logo

Marte has been one of the more unlucky hitters in the league this season, and he should have several more bombs.

The dome is open today, and with temps in the 90s, the ball should be flying well.

Sugano is one of the best matchups in the league for power, and I have the true odds around +350 today, making this a great EV bet.

Pick: Ketel Marte Home Run



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About the Author
Grant NeifferVerified Action Expert

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