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MLB Picks, Best Bets, Props, Predictions Today – September 27

MLB Picks, Best Bets, Props, Predictions Today – September 27 article feature image
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We have a full 15-game slate for this final regular-season Saturday, with massive playoff implications in several matchups.

So there's a lot of baseball on the schedule today, but we have you covered. Our MLB betting experts and systems have sifted through the latest MLB odds and have made their predictions below.

So, continue reading for today's MLB best bets.

Playbook

MLB Best Bets Today

The team logos in the table below represent each of the matchups that our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.

GameTime (ET)Pick
Baltimore Orioles LogoNew York Yankees Logo
1:05 p.m.
Colorado Rockies LogoSan Francisco Giants Logo
4:05 p.m.
Cincinnati Reds LogoMilwaukee Brewers Logo
7:15 p.m.
Los Angeles Dodgers LogoSeattle Mariners Logo
9:40 p.m.
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game.

Bet Labs' Orioles vs Yankees Best Bet: Expect a Low-Scoring Game

Baltimore Orioles Logo
Saturday, September 27
1:05 p.m. ET
MLB.TV
New York Yankees Logo
Under 9 (-120)
bet365 Logo

By Bet Labs

This MLB betting system, titled "Steam Unders with Low OU Support", is built on the premise that sharp money moving totals downward, paired with weak public support on the under, creates an exploitable edge in the betting market.

This afternoon's OriolesYankees matchup fits perfectly into these conditions.

The strategy focuses on regular-season games from 2019 to 2025, where the closing total lands between 8 and 10 —sweet spots for scoring volatility.

It isolates games where the over/under line has dropped significantly from open to close, signaling smart money on the under, yet public sentiment heavily favors the over, with only a small share of bets backing the under. This mismatch between money and ticket count indicates potential value, especially when the difference between those two figures is meaningful but not extreme.

To reduce noise, the system excludes games played in extreme heat or cold, only including those where temperatures range from mild to warm. It also requires both teams to have a recent record of games that hover around the total, suggesting no extreme streaks skewing expectations.

These filters ensure that neither team is riding unsustainable over or under trends. Ultimately, this system looks for low-confidence unders that have been steamed down by sharp bettors, where public interest is light and the number still sits within a realistic scoring range.

The result is a consistent edge, backed by a high sample size and strong return on investment.

MLB Icon
Evan Abrams / Bet Labs – Steam Unders with Low OU Support
the game was played during the 2025 or 2024 or 2023 or 2022 or 2021 or 2020 or 2019 season
the visitor team's 3 Games OU Margin is between -2.3 and 5.25
the home team's 3 Games OU Margin is between -3.33 and 3.19
the temperature is between 1 and 87 degrees
the o/u change from open to close is between -1.5 and 0
the closing total is between 8 and 10
the difference between money % and ticket % is between 1 and 87
the over/under % is between 1% and 29%
betting on the Under
the game is played during the Regular season
$14,565
WON
587-405-49
RECORD
59%
WIN%

Pick: Under 9 (-120)



Derek Carty's Rockies vs Giants: Great Value on This HR Prop

Colorado Rockies Logo
Saturday, September 27
4:05 p.m. ET
MLB.TV
San Francisco Giants Logo
Jordan Beck Home Run (+700)
bet365 Logo

By Derek Carty

There is excellent value on Jordan Beck's home runs prop.

THE BAT X is projecting the Rockies outfielder to record 0.12 home runs, and oddsmakers are implying 0.09. The model believes there is an 11% chance he records at least one homer today.

Love THE BAT X? Get all of Carty’s sports betting projections at EV Analytics!

Pick: Jordan Beck Home Run (+700)



Bet Labs's Reds vs Brewers Best Bet: System Recommends the Under

Cincinnati Reds Logo
Saturday, September 27
7:15 p.m. ET
MLB.TV
Milwaukee Brewers Logo
Under 7.5 (+100)
bet365 Logo

By Bet Labs

This system targets unders in MLB series games (Game 2 or later) where both teams have winning records, suggesting quality pitching and competitive matchups, such as today's Reds vs. Brewers.

However, public betting leans toward the over — likely expecting fireworks between top teams — which creates contrarian value on the under.

By capitalizing on low public support for the under (≤35%), the strategy fades public perception in favor of market inefficiencies, especially when bettors overestimate offensive output late in a series..

MLB Icon
Evan Abrams – Contrarian Unders for Winning Teams, Later in Series
the game is played during the Regular or Postseason season
betting on the Under
the home team's win percentage is between 51% and 100%
the visitor team's win percentage is between 51% and 100%
the over/under % is between 0% and 35%
the series game # is between 2 and 100
$13,716
WON
1387-1181-110
RECORD
54%
WIN%

Pick: Under 7.5 (+100)



PRO's Dodgers vs Mariners Best Bet: Fade Glasnow's Strikeouts

Los Angeles Dodgers Logo
Saturday, September 27
9:40 p.m. ET
MLB.TV
Seattle Mariners Logo
Tyler Glasnow Under 6.5 Strikeouts (-115)
bet365 Logo

By Action PRO

PRO projects Dodgers starter Tyler Glasnow with 6.09 strikeouts today, which represents an excellent 14.5% edge against the market.

Although Glasnow has good strikeout numbers, with 103 Ks in 87 and 1/3 innings pitched, his home/away splits are telling.

He holds a much higher 4.56 ERA on the road, compared to 2.77 at Dodger Stadium, and he should be on a short leash tonight to avoid any injuries before the start of the playoffs.

Also, Glasnow has not recorded more than six Ks in any of his previous five starts on the road.

With the line at 6.5, you can fade the right-hander tonight against the Mariners.

Pick: Tyler Glasnow Under 6.5 Strikeouts (-115)



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Action Network is a team of seasoned sports betting experts specializing in a broad range of sports, from the NFL and NBA to less mainstream options like cricket and darts. Their staff includes well-known analysts like Sean Koerner and Stuckey, recognized for their accurate predictions and deep sports knowledge. The team is dedicated to delivering expert analysis and daily best bets, ensuring bettors are well-informed across all major sports.

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