The Louisville Cardinals face the Coastal Carolina Chanticleers to kick off the semifinals of the 2025 Men's College World Series. First pitch is set for 2 p.m. ET on ESPN.
Coastal Carolina enters as a big -238 favorite on the moneyline with the over/under sitting at 11. The run line, meanwhile, sits at Coastal Carolina -2.5 (+110) and Louisville +2.5 (-140).
Let's dive into our Louisville vs. Coastal Carolina prediction and NCAA baseball picks for the College World Series on Wednesday, June 18.
Louisville vs Coastal Carolina Prediction
- Louisville vs. Coastal Carolina Pick: Coastal Carolina -1.5 (Play to -2.5 at +110)
My Coastal Carolina vs. Louisville best bet is on the Chanticleers to cover the run line, with the best line currently available at bet365.
Louisville vs Coastal Carolina Odds
| Louisville Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
+2.5 -140 | 11 -115o / -115u | +180 |
| Coastal Carolina Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
-2.5 +110 | 11 -115o / -115u | -238 |
- Louisville vs Coastal Carolina Moneyline: Louisville +180 · Coastal Carolina -238
- Louisville vs Coastal Carolina Over/Under: 11 Runs
- Louisville vs Coastal Carolina Run Line: Coastal Carolina -2.5 (+110) · Louisville +2.5 (-140)
Louisville vs Coastal Carolina Pick, Best Bets
The Louisville Cardinals pulled off a massive upset yesterday, eliminating the Oregon State Beavers. However, they've taken the long road to get here and are in dire straits on the mound.
They have only four arms that haven't seen any action yet, and they own a collective ERA of 6.78. If worse comes to worst, I wouldn't rule out ace Patrick Forbes making a relief appearance on four days' rest, but they may be saving him for a potential elimination game tomorrow.
However, that plan is unlikely to come to fruition, as Coastal is primed to win this game handily. Not only will its elite lineup face a gassed Louisville pitching staff, but it has multiple quality options to turn to on the mound.
We should see No. 3 starter Riley Eikhoff come back this afternoon in some capacity after he started the opening matchup and threw only 45 pitches. After Eikhoff, the Chanticleers have seven fresh arms in addition to the relievers that pitched over their first two games.
While Louisville has been a pleasant surprise to this point, its lack of starting pitching will catch up to it today. Take Coastal Carolina to cover the run line as it secures a spot in the College World Series finals.
Pick: Coastal Carolina -1.5 (Play to -2.5 at +110)
