The Louisville Cardinals host the Miami Hurricanes in the Louisville Super Regional for the 2025 NCAA Baseball Tournament.
Louisville enters as a -160 favorite to advance to the College World Series, while Miami sits at +130.
Let's dive into our Louisville vs. Miami prediction and NCAA baseball picks for the Louisville Super Regional.
Louisville vs Miami Prediction
- Louisville to Win Super Regional (-160 · DraftKings)
- Game 1: Louisville -1.5 (+125 · bet365)
We have two best bets for the Louisville Super Regional. Check out more college baseball content on our NCAA Baseball page.
Louisville vs Miami Odds
 | Louisville Odds | -160 (Series) |
 | Miami Odds | +130 (Series) |
Read Doug Ziefel's full college baseball betting preview for the 2025 NCAA Super Regionals here.
Projected Pitching Matchups for Louisville Super Regional
- Game 1: Patrick Forbes (LOU) vs. Griffin Hugus (MIA) · Friday, June 6, 3 pm ET (ESPN2)
- Game 2: Peter Michael (LOU) vs. AJ Ciscar (MIA) · Saturday, June 7, 11 am ET (ESPN)
- Game 3 ( If necessary): Ethan Eberle (LOU) vs. Reese Lumpkin (MIA) · Sunday, June 8
Both of these teams are a surprise. The Louisville Cardinals took down No. 1 overall national seed Vanderbilt and are now hosting a Super Regional.
What got the Cardinals through the Nashville Regional was excellent pitching, as they allowed just five runs in three games. Now, their pitching is set to shine again against the Miami Hurricanes.
Miami found lightning in a bottle in Hattiesburg, bouncing back to beat Southern Miss on Monday after losing to the Golden Eagles on Sunday.
Despite containing lineups like USM and Alabama, Miami's pitching depth is a concern when matched up with Louisville.
Additionally, we should see these two teams trend in opposite directions at the plate. Miami was inconsistent this season, ranking 176th in batting average and 129th in wRC+. Meanwhile, the Cardinals sat 32nd in batting average and 53rd in wRC+.
With Miami overperforming and Louisville underperforming offensively, we should see the Cardinals pull away in this series.
Louisville vs Miami Pick, Best Bets
- Louisville to Win Super Regional (-160 · DraftKings)
- Game 1: Louisville -1.5 (+125 · bet365)
