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Kentucky vs. Louisville Odds & Betting Predictions - November 12, 2025

Kentucky at Louisville

1:00 am • ESPN

Kentucky Wildcats

17-9
88
88 - 96

Louisville Cardinals

19-7
96

Kentucky at Louisville Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Kentucky
17-9
+4.5
+6-107
o173.5-111
+196
Louisville
19-7
u168.5
-6-112
u173.5-109
-245
location pinWednesday 1:00 a.m.
November 12, 2025
KFC Yum! CenterLouisville
Kentucky vs. Louisville Expert Picks
JMann
JMann
Last 30d: 38-35-0 (+0.3u)
M.Brown o5.5 Ast-106
1u
Picks Office
Picks Office
Last 30d: 200-127-3 (+58.2u)
Under 174.5-110
2u
X: PicksOffice
Tickle the Twine
Tickle the Twine
Last 30d: 52-38-0 (+8.6u)
Under 174.5-110
1u
Sandy Plashkes
Sandy Plashkes
Last 30d: 82-80-6 (-7.4u)
LOU -6.5-110
1u
@Mjaybrxd tail
Mjaybrod
Mjaybrod
Last 30d: 56-40-0 (+19.7u)
LOU -6.5-105
0.95u
CBB POD
LOU -6.5-105
0.95u
Number is huge for a reason
Ryan Minion
Ryan Minion
Last 30d: 216-226-3 (+59.8u)
M.Brown o1.5 3pt M-120
$1.00
M.Brown o23.5 Pts+Rebs+Ast-115
$1.00
FTN Fantasy
FTN Fantasy
Last 30d: 156-173-2 (-34.8u)
LOU -3.5-115
0.87u
Ryan Minion
Ryan Minion
Last 30d: 216-226-3 (+59.8u)
LOU -160
$1.00

Kentucky vs. Louisville Previews & Analysis

  • Kentucky vs Louisville: How to Bet This Juicy Rivalry Duel article feature image

    Kentucky vs Louisville: How to Bet This Juicy Rivalry Duel

    Dead President Picks•
    Nov 11, 2025 UTC
  • Our Staff's Best Bets for Louisville vs Kentucky article feature image

    Our Staff's Best Bets for Louisville vs Kentucky

    Action Network Staff•
    Nov 11, 2025 UTC
See more NCAAB Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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Kentucky vs. Louisville Public Betting Percentages

Away Logo

Kentucky

Public

Home Logo

Louisville

31%

Bets%

69%

Money%

NCAAB Public Betting Right Arrow

Betting Trends

  • Louisville are 4-1 in their last 5 games.
  • Louisville are 2-3 in their last 5 games against the spread
  • Louisville are 5-6 in their road games against the spread
  • The totals have gone OVER in 3 of Louisville' last 5 games
  • The totals have gone OVER in 5 of Louisville' 15 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Louisville		13-138-75-610-80-3
Kentucky		12-149-103-44-74-4

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Louisville		10-165-105-68-100-3
Kentucky		13-139-104-34-74-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Louisville		19-7N/AN/A14-40-3
Kentucky		17-9N/AN/A7-43-5

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 7thJKSTW 106-70-38.5 LO 165.5-
Nov 4thSCSTW 104-45-36.5 WU 159.5-
Mar 20thCREIL 75-89-3 LO 146.5CREI -167
Mar 16th@DUKEL 62-73+6.5 LU 148.5DUKE +215
Mar 15thCLEMW 76-73+2.5 WO 141.5LOU +120

Louisville vs. Kentucky Injury Updates

Louisville Injuries

    Kentucky Injuries

    • Jaland Lowe
      G

      Lowe is out for season with arm

      Out for Season

    • Jayden Quaintance
      F

      Quaintance is out with knee

      Out

    • Kam Williams
      G

      Williams is out with foot

      Out

    See more NCAAB Injuries Right Arrow
    Team Stats

    32-68 (47%)
    Field Goals
    31-69 (45%)
    12-16 (75%)
    Free Throws
    21-31 (68%)
    12-34 (35%)
    3P
    13-40 (33%)
    40
    Rebounds
    37
    14
    Assists
    20
    14
    Turnovers
    6
    4
    Steals
    11
    3
    Blocks
    3
    21
    Fouls
    19

    Kentucky vs. Louisville Odds Comparison

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    Kentucky at Louisville Team Totals

    MatchupOverUnder
    Kentucky
    17-9
    N/A
    N/A
    Louisville
    19-7
    N/A
    N/A