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College Basketball Best Bets: Odds, Predictions, Top Picks for Saturday, Jan. 10

College Basketball Best Bets: Odds, Predictions, Top Picks for Saturday, Jan. 10 article feature image
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The NFL Playoffs start today, but the action on the hardwood can't be missed.

With conference play in full swing, our college basketball betting experts have picks on marquee matchups that will have a playoff atmosphere of their own.

Check out our four college basketball best bets, including NCAAB predictions, picks and odds for Saturday, January 10.


College Basketball Best Bets, Game Predictions Today

GameTime (ET)Pick
Boston College Eagles LogoLouisville Cardinals Logo
12 p.m.
Tennessee Volunteers LogoFlorida Gators Logo
12 p.m.
Southern Methodist Mustangs LogoDuke Blue Devils Logo
2 p.m.
Arkansas Razorbacks LogoAuburn Tigers Logo
6 p.m.
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NCAAB Odds page, which automatically surfaces the best lines for every game.

Boston College vs. Louisville Prediction

Boston College Eagles Logo
Saturday, Jan. 10
12 p.m. ET
The CW Network
Louisville Cardinals Logo
Over 148.5
DraftKings  Logo

By Alex Kolodziej

This early afternoon contest is particularly interesting for bettors because it features a sharp signal from PRO Systems – proprietary, backtested betting models available to premium subscribers.

PRO Systems use historical data and current market movements to identify high-value picks.

Bettors looking for an edge should focus on the “Home Overs with Steam” PRO System, which is active on this matchup. This model targets college basketball overs when strong home favorites (-15 or more) also feature a steam move by at least 1+.

The logic is neat: When the over/under rises in spots where the home team is a large favorite, especially during the critical winter months of January through March, it often signals a tempo or efficiency mismatch that the market underestimates.

Historically, this system has thrived by capturing games where home favorites tend to control pace and flow, generating enough scoring opportunities to push the total above early expectations.

The Boston College vs. Louisville total has been bet up by multiple points already. Given the spread range and timeframe, it set off a play on Eagles vs. Cardinals over.

Pick: Over 148.5

For the full look at this game from a PRO angle and how to subscribe to Action PRO:

College Basketball Odds: Steam Key to Boston College vs Louisville Pick Image

Tennessee vs. Florida Prediction

Tennessee Volunteers Logo
Saturday, Jan. 10
12 p.m. ET
ESPN
Florida Gators Logo
Tennessee +5
bet365 Logo

By Doug Ziefel

The biggest spread edge of the slate from our Action PRO Projections happens to be on one of the biggest matchups of the day.

The No. 21 Tennessee Volunteers travel to Gainesville to take on the defending champs, the Florida Gators.

The Gators have struggled against ranked opponents, which has caused them to fall out of the top 25, but they're two-possession favorites over the Volunteers, who've already beaten Houston.

Our PRO Projections indicate they're getting too much love; this spread should be closer to +2.

This is an 11% edge that you can back with confidence.

Pick: Tennessee +5


SMU vs. Duke Prediction

Southern Methodist Mustangs Logo
Saturday, Jan. 10
2 p.m. ET
ESPN
Duke Blue Devils Logo
Over 157.5 or Better
FanDuel Logo

By Jordan Mann

I really like what I saw from Duke's defense against Louisville in the second half, but can it do it again against SMU's talented backcourt?

Duke will dictate points in the paint by playing through Cam Boozer, something SMU won't have an answer for.

On the flip side, can Duke's perimeter defense stay in front of SMU's guards that thrive on iso's and pick-and-rolls? That's something Florida State had a lot of success with against Duke a couple of games ago.

I'm expecting some high-level buckets to be made on Saturday.

Pick: Over 157.5 or Better


Arkansas vs. Auburn Prediction

Arkansas Razorbacks Logo
Saturday, Jan. 10
6 p.m. ET
ESPN
Auburn Tigers Logo
Over 171
bet365 Logo

By Evan Abrams

Both squads have demonstrated strong offensive firepower this season, with Arkansas ranking among the nation's top-scoring teams and Auburn consistently putting up high totals in its games.

That's why this spot fits perfectly for the over 171 in the “Don’t Over-think It” system.

This system focuses on straightforward logic in college basketball totals betting by identifying games where both teams have shown a consistent trend toward high scoring.

When both the home and visiting teams have gone over in at least half of their games, it signals that offensive rhythm and tempo outweigh defensive variance.

These matchups often feature teams comfortable in fast-paced environments, with shooting efficiency and possessions driving outcomes above expectations.

By targeting games with closing totals in a reasonable range, the system avoids inflated lines and capitalizes on spots where the market may hesitate to adjust enough for sustained offensive performance, proving that sometimes the simplest angle is the right one.

Pick: Over 171

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