Louisville vs. South Florida Odds
| Louisville Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-6.5 -110 | 163.5 -115o / -105u | -255 |
| South Florida Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+6.5 -110 | 163.5 -115o / -105u | +205 |
The 2026 NCAA Tournament field has been announced and Louisville will take on South Florida in Round 1 of the East region. Here's everything you need to know about Louisville vs. South Florida odds, spread and more.
Louisville opened as a 6.5-point favorite over South Florida in the first round of the NCAA Tournament. The total is set at over/under 163.5 points scored by both teams combined.
Find out how No. 6-seeded Louisville and No. 11-seeded South Florida match up ahead of their opening round matchup.
Louisville vs. South Florida Analysis
South Florida is a curveball for any opponent.
The Louisville coaching staff will have its hands full preparing the Cardinals to face a team with such a distinct personality.
South Florida led the nation in both free throws attempted and made per game, and ranked in the top ten nationally in offensive rebound rate and shortest average 2-point attempt.
The Bulls attack the basket, over and over. They run the floor, playing at the nation’s 15th-fastest tempo, and then either toss a quick 3 or make sure they get something near the rim, hopefully with contact.
Louisville’s defense checks most of the boxes to stop that attack. The Cardinals love a quick tempo and ranked in the top 10% nationally in defensive rebounding.
If there’s an issue, it’s in the foul column. Louisville ranked 10th among ACC teams in free-throw rate allowed.
Officiating will be a major factor in whether the Bulls can threaten Louisville. Most importantly, this should be a high-scoring game with a massive total.
–Shane McNichol
For more coverage of the 2026 NCAA Tournament and Selection Sunday, make sure to check out our experts' live reactions to the bracket reveal and the Selection Sunday live show, where you can get their instant analysis on every matchup as well as some early insights to help you make your bets.
