Sweet 16 Odds, Lines, Spreads, Predictions for Every Game | March Madness 2024
Photo by Joe Murphy via Getty Images. Pictured: The Houston Cougars celebrate advancing to the Sweet 16 as we preview the next round of March Madness with Sweet 16 odds, lines, spreads, predictions and picks for every game.
The first weekend of March Madness is complete. And after a few days off, we'll move into the Sweet 16 on Thursday and Friday.
But you don't have to wait to start breaking down the Sweet 16 odds and Sweet 16 predictions. Here are the odds and our betting expert's predictions for the point spread, total and final score for every game.
You'll also find a running tracker of all of our expert picks for each Sweet 16 game based on the latest 2024 March Madness odds.
Sweet 16 Odds, Lines, Spreads, Predictions for Every Game
| Game | Odds, Spread | Prediction |
|---|---|---|
| Arizona -7 | ||
| UConn -10 | ||
| UNC -4 | ||
| Iowa State -2.5 | ||
| Marquette -6.5 | ||
| Purdue -4.5 | ||
| Houston -3.5 | ||
| Tennessee -2.5 | ||
Odds via bet365. Always shop for the best price using our NCAAB Odds page, which automatically surfaces the best lines for every game. | ||
No. 6 Clemson vs No. 2 Arizona Odds, Prediction
| Clemson Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+7 -110 | 152 -110o / -110u | +250 |
| Arizona Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-7 -110 | 152 -110o / -110u | -310 |
Clemson vs Arizona Predictions:
Arizona -6 | Over/Under 151 | Final Score: Arizona 79, Clemson 73
No. 5 San Diego State vs No. 1 UConn Odds, Prediction
| San Diego State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+10 -110 | 135 -110o / -110u | +370 |
| UConn Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-10 -110 | 135 -110o / -110u | -485 |
San Diego State vs UConn Predictions:
UConn -9 | Over/Under 135 | Final Score: UConn 72, San Diego State 63
No. 4 Alabama vs No. 1 UNC Odds, Prediction
| Alabama Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+4 -110 | 173.5 -110o / -110u | +165 |
| UNC Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-4 -110 | 173.5 -110o / -110u | -200 |
Alabama vs UNC Predictions:
UNC -1 | Over/Under 158.5 | Final Score: UNC 80, Alabama 79
No. 3 Illinois vs No. 2 Iowa State Odds, Prediction
| Illinois Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+2.5 -110 | 146 -110o / -110u | +125 |
| Iowa State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2.5 -110 | 146 -110o / -110u | -150 |
Illinois vs Iowa State Predictions:
Iowa State -1 | Over/Under 142 | Final Score: Iowa State 72, Illinois 71
No. 11 NC State vs No. 2 Marquette Odds, Prediction
| NC State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+6.5 -110 | 150.5 -110o / -110u | +235 |
| Marquette Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-6.5 -110 | 150.5 -110o / -110u | -290 |
NC State vs Marquette Predictions:
Marquette -8.5 | Over/Under 145.5 | Final Score: Marquette 77, NC State 69
No. 5 Gonzaga vs No. 1 Purdue Odds, Prediction
| Gonzaga Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+4.5 -110 | 154 -110o / -110u | +165 |
| Purdue Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-4.5 -110 | 154 -110o / -110u | -200 |
Gonzaga vs Purdue Predictions:
Purdue -4.5 | Over/Under 152.5 | Final Score: Purdue 79, Gonzaga 74
No. 4 Duke vs No. 1 Houston Duke Odds, Prediction
| Duke Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+3.5 -106 | 133.5 -115o / -105u | +140 |
| Houston Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-3.5 -114 | 133.5 -115o / -105u | -170 |
Houston vs Duke Predictions:
Houston -4 | Over/Under 134.5 | Final Score: Houston 70, Duke 65
No. 3 Creighton vs No. 2 Tennessee Odds, Prediction
| Creighton Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+2.5 -110 | 144 -110o / -110u | +125 |
| Tennessee Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2.5 -110 | 144 -110o / -110u | -150 |
Creighton vs Tennesee Predictions:
Tennessee -4 | Over/Under 140.5 | Final Score: Tennessee 72, Creighton 68
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