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Louisville vs. SMU Odds & Betting Predictions - November 22, 2025

Louisville at SMU

5:00 pm • ESPN2

Louisville Cardinals

0-1
6
6 - 38

SMU Mustangs

1-0
38

Louisville at SMU Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Louisville
0-1
+3.5
+3.5-105
o49.5-110
+154
SMU
1-0
u49.5
-3.5-110
u49.5-110
-190
location pinSaturday 5:00 p.m.
November 22, 2025
Gerald J. Ford StadiumDallas
Louisville vs. SMU Expert Picks
The Degenerates
The Degenerates
Last 30d: 45-47-2 (-5.8u)
SMU -2.5 (Live)-115
1u
Picks Office
Picks Office
Last 30d: 0-0-0 (+0.0u)
SMU -3-115
0.87u
Link in Bio for early access
New Owner
New Owner
Last 30d: 0-0-0 (+0.0u)
LOU +4.5-110
1.1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 9-21-0 (+1.8u)
LOU +4-110
1.1u
Topper
Topper
Last 30d: 150-168-6 (-21.4u)
LOU +130 (1H)
0.5u
2.56% ev
Big Bets On Campus (CFB)
Big Bets On Campus (CFB)
Last 30d: 18-16-0 (+2.4u)
SMU -3-102
0.98u
@_Collin1 https://myaction.app/froqdThRtYb
Mike McNamara
Mike McNamara
Last 30d: 56-59-1 (+5.5u)
LOU +4-110
0.35u
Collin Wilson
Collin Wilson
Last 30d: 22-17-0 (+3.1u)
SMU -3-110
1u
Project SMU -3.5; great situational spot, Louisville on back to back losses and off Clemson w Kentucky rivalry on deck. SMU off a bye week

Louisville vs. SMU Previews & Analysis

  • Our CFB Best Bets For Saturday's Noon Slate article feature image

    Our CFB Best Bets For Saturday's Noon Slate

    Action Network Staff•
    Nov 22, 2025 UTC
  • Your Week 13 NCAAF Betting Cheat Sheet article feature image

    Your Week 13 NCAAF Betting Cheat Sheet

    Pete Ruden•
    Nov 22, 2025 UTC
  • 'Line Freeze' Model: 3 No-Doubt Sharp Sides article feature image

    'Line Freeze' Model: 3 No-Doubt Sharp Sides

    Alex Kolodziej•
    Nov 22, 2025 UTC
  • SMU vs Louisville: Collin's Pick article feature image

    SMU vs Louisville: Collin's Pick

    Collin Wilson•
    Nov 22, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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Louisville vs. SMU Public Betting Percentages

Away Logo

Louisville

Public

Home Logo

SMU

33%

Bets%

67%

Money%

NCAAF Public Betting Right Arrow

Betting Trends

  • SMU are 1-0 in their last 5 games.
  • SMU are 0-0 in their last 5 games against the spread
  • SMU are 0-0 in their road games against the spread
  • The totals have gone OVER in 0 of SMU' last 1 games

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
SMU		0-0-1N/A0-0-10-0-1N/A
Louisville		1-0N/AN/AN/A1-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
SMU		0-1N/A0-10-1N/A
Louisville		1-0N/AN/AN/A1-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
SMU		1-0N/AN/A1-0N/A
Louisville		0-1N/AN/AN/A0-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 8th@BCW 45-13-10.5 WO 54.5SMU -425
Nov 1stMIAW 26-20+8.5 WU 50.5SMU +260
Oct 25th@WFL 12-13-5.5 LU 52.5WF -210
Oct 18th@CLEMW 35-24+3.5 WO 49.5SMU +146
Oct 11thSTANW 34-10-19.5 WU 55.5SMU -1100
Team Stats

Total

228
Total Yards
485
49
Total Plays
74
4.653061224489796
Yards Per Play
6.554054054054054

Passing

100
YDS
307
14/20
Comps/Atts
30/38
5
YPA
8.078947368421053
0/1
TDs/INTs
3/0
2/10
Sacks/Yards
1/12

Rushing

128
Rush Yards
178
29
Attempts
36
4.413793103448276
YPC
4.944444444444445
0
TDs
2

Turnovers

0
Fumbles Lost
0
1
Interceptions
0

Efficiency

2/2 100%
Redzone
4/4 100%
3/12 0%
3rd Down
9/13 0%
0/0 0%
4th Down
0/0 0%

First Downs

12
Total
28
5
Pass
15
6
Rush
10
1
Penalty
3

Misc

6/47
Penalties/Yards
7/70

Louisville vs. SMU Odds Comparison

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Louisville at SMU Team Totals

MatchupOverUnder
Louisville
0-1
N/A
N/A
SMU
1-0
N/A
N/A