The Arizona State Sun Devils take on the Iowa State Cyclones in Ames, Iowa. Kickoff is set for 1:00 p.m. EDT on TNT.
Iowa State is favored by -7.5 points on the spread with a moneyline of -330. The total is set at 49.5 points.
Here’s my Arizona State vs. Iowa State prediction and college football picks for Saturday, November 1, 2025.
Arizona State vs Iowa State Prediction
- Arizona State vs. Iowa State Pick: Arizona State +8 (-110, bet365)
My Iowa State vs. Arizona State best bet is on the Sun Devils. Find the best line available on our live NCAAF odds page.
Arizona State vs Iowa State Odds
| Arizona St Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+8 -110 | 50 -110o / -110u | +255 |
| Iowa State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-8 -110 | 50 -110o / -110u | -315 |
- Arizona State vs Iowa State point spread: Iowa State -8 (-110), Arizona St +8 (-110)
- Arizona State vs Iowa State over/under: 50 (-110o / -110u)
- Arizona State vs Iowa State moneyline: Arizona St +255, Iowa State -315
Arizona St vs Iowa State Pick
This game triggered one of our Action Network PRO systems, powered by Evan Abrams.
In both regular season and postseason college football, home favorites in conference play who have performed poorly against the spread in recent games are often overvalued.
A string of ATS losses signals that market expectations have consistently outpaced on-field results, yet public perception and home-field bias can still inflate the line.
Conference opponents, familiar with schemes and tendencies, are well-positioned to exploit these weaknesses.
This creates an environment where fading the struggling home favorite offers consistent value.
While I'm terrified of backing Arizona State without Sam Leavitt (out for Saturday), I'm not scared of fading Iowa State, which has been super unimpressive this season all around — the Cyclones rank 76th nationally in EPA per Play and 62nd in EPA per Play allowed.
Arizona State still ranks in the top 15 nationally in EPA per Rush, so I could see the Sun Devils playing keep-away from Rocco Becht and staying within an inflated number against a mediocre Cyclones squad.
Pick: Arizona State +8 (-110, bet365)
