The Boston College Eagles take on the Louisville Cardinals in Louisville, Kentucky, on Saturday, Oct. 25. Kickoff is set for 7:30 p.m. ET on ACC Network.
Louisville is favored by 25.5 points on the spread with a moneyline of -2800. Boston College, meanwhile, comes in as a +25.5 underdog and is +1300 on the moneyline to pull off the upset. The over/under sits at 54.5 total points.
Here’s my Boston College vs. Louisville prediction and college football picks for Saturday, October 25.
Boston Col vs Louisville Prediction
- Boston College vs. Louisville Pick: Boston College +25
My Louisville vs. Boston College best bet is on the Eagles to cover the spread. Find the best line available on our live NCAAF odds page.
Boston College vs Louisville Odds
| Boston College Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+25.5 -110 | 54.5 -110o / -110u | +1300 |
| Louisville Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-25.5 -110 | 54.5 -110o / -110u | -2800 |
- Boston College vs Louisville Spread: Louisville -25.5, Boston College +25.5
- Boston College vs Louisville Over/Under: 54.5 Points
- Boston College vs Louisville Moneyline: Boston College +1300, Louisville -2800
Boston College vs Louisville College Football Betting Preview
Boston College Eagles Betting Preview: Can BC Avoid Blowout?
Boston College’s record doesn’t inspire much confidence, but its offense has been quietly respectable despite the team’s struggles.
The Eagles rank 55th nationally in Success Rate, 67th in Havoc allowed and 27th in tempo, showing that they can sustain drives and keep opposing defenses on the field.
They sit 56th in overall offensive grade, per PFF, right around the national average. They're not flashy, but they're far from broken.
They move the ball methodically, avoid catastrophic mistakes and play at one of the faster paces in the ACC (23rd nationally in tempo), which can frustrate defenses built around rhythm.
The issue for Boston College hasn’t been talent; it’s been consistency. BC ranks 107th in Finishing Drives, often settling for field goals or stalling inside the 30.
But in a game like this, where the spread is north of three touchdowns, sustained movement and clock control are exactly what bettors should want.
The Eagles’ ability to convert short passes, spread the field and keep their quarterback upright (top-70 nationally in protection metrics) should be enough to hang around longer than expected.
Against an elite Louisville defense, time of possession may be the most important stat for the Eagles offense.
Louisville Cardinals Betting Preview: Elite Defense Leads the Way
Louisville has been the better team all season, but “better” and “dominant” are two different things.
The Cardinals rank 62nd in PFF offensive grade, an indicator of a unit that’s capable but not especially explosive. They sit 56th in Offensive Success Rate, 77th in Finishing Drives and 55th in explosiveness, all solidly average national marks.
This is a team that relies more on timing and execution than raw athleticism, and when that timing slips, the offense can bog down quickly.
Defensively, Louisville has been elite, ranking sixth in Success Rate allowed and 27th in Finishing Drives, but it still gives up big plays in space (80th in explosiveness allowed).
The Cardinals are undeniably the better team, but their efficiency metrics show a squad that wins through structure, not steamrolling. That profile makes it hard to trust as a four-score favorite, especially in a letdown spot.
Boston College vs Louisville Pick, Betting Analysis
This feels like the perfect “hangover spot” for Louisville.
It's coming off a massive emotional win over Miami in the kind of game that drains energy and sharpness the following week.
Boston College, meanwhile, has nothing to lose. It plays fast, keeps defenses off balance and does just enough offensively to frustrate more talented teams.
While the Eagles defense is flawed, their offense’s ability to stay on schedule and chew clock makes them a dangerous underdog in this situation.
Louisville will almost certainly win, but its offensive rhythm and lack of explosive consistency make covering 25 points a tall task. Expect the Cardinals to control the game without ever fully putting it away.
Pick: Boston College +25
Boston College vs Louisville Betting Trends
