The Clemson Tigers take on the Boston College Eagles in Chestnut Hill, Massachusetts. Kickoff is set for 7:30 p.m. EDT on ACC Network.
Clemson is favored by 14 points on the spread with a moneyline of -600. The total is set at 54 points.
Here’s my Clemson vs. Boston College prediction and college football picks for Saturday, October 11, 2025.
Clemson vs Boston College Prediction
- Clemson vs. Boston College Pick: Clemson -14 (-110, bet365)
My Boston College vs. Clemson best bet is on the Tigers to cover. Find the best line available on our live NCAAF odds page.
Clemson vs Boston College Odds
| Clemson Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-14 -110 | 54 -110o / -110u | -600 |
| Boston Col Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+14 -110 | 54 -110o / -110u | +450 |
- Clemson vs Boston College point spread: Clemson -14 (-110), Boston Col +14 (-110)
- Clemson vs Boston College over/under: 54 (-110o / -110u)
- Clemson vs Boston College moneyline: Clemson -600, Boston Col +450
Clemson vs Boston College Preview
This game activated one of our PRO betting systems, powered by Evan Abrams:
Road Trip Luck Low targets college football conference games where travel fatigue and recent turnover trends create hidden value.
The focus is on teams playing the second game or later of a road stretch, where continuity and preparation can become advantages against opponents struggling with ball security.
When the opposing team has lost the turnover battle in consecutive games, it often signals instability in execution rather than bad luck, a vulnerability that can be exploited by a team already adjusted to the road.
With a total below 60, the matchup is expected to be lower scoring, reducing volatility and emphasizing efficiency over explosiveness.
This system benefits from disciplined road teams facing turnover-prone opponents in contained scoring environments, where consistency and mistake avoidance often determine the outcome.
Boston College hasn’t looked very buttoned up lately. The Eagles have dropped four straight, committing nine turnovers while grabbing only two during the stretch.
Quarterback Dylan Lonergan has flashed high potential at moments this season, but he’s quickly regressing. He’s thrown three picks on six Turnover-Worthy Plays over the past three weeks, averaging only 5.3 yards per attempt over the past two weeks (286 yards on 54 attempts).
I’m no fan of Clemson, but perhaps the Tigers found something during last week’s blowout of North Carolina. At the same time, Lonergan and the Eagles pieced together arguably the worst performance for any Power Conference team this season in a 48-7 loss to Pitt (-0.31 EPA per Play, 31% Success Rate, 4.1 yards per play).
From a schematic perspective, Clemson can’t run the ball, but you want to beat Boston College through the air, as the Eagles’ secondary ranks 105th nationally in EPA per Pass allowed and 95th in PFF’s Coverage grades.
Thus, Cade Klubnik might be forced to attack early and often through the air, possibly resulting in a blowout, if things actually go right.
Pick: Clemson -14 (-110, bet365)
