The Clemson Tigers take on the South Carolina Gamecocks in Columbia, South Carolina. Kickoff is set for 12:00 p.m. EST on SEC Network.
South Carolina is favored by 2.5 points on the spread with a moneyline of -140. The total is set at 46.5 points.
Here’s my Clemson vs. South Carolina prediction and college football picks for Saturday, November 29, 2025.
Clemson vs South Carolina Prediction
- Clemson vs. South Carolina Pick: Clemson ML (+120, bet365)
My South Carolina vs. Clemson best bet is on the Tigers to win outright. Find the best line available on our live NCAAF odds page.
Clemson vs South Carolina Odds
| Clemson Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+2.5 -110 | 46.5 -110o / -110u | +120 |
| South Carolina Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-2.5 -110 | 46.5 -110o / -110u | -140 |
- Clemson vs South Carolina point spread: South Carolina -2.5 (-110), Clemson +2.5 (-110)
- Clemson vs South Carolina over/under: 46.5 (-110o / -110u)
- Clemson vs South Carolina moneyline: Clemson +120, South Carolina -140
Clemson vs South Carolina Preview
Clemson Tigers Betting Preview: Quiet but Solid
To say this season has been a disappointment for the Tigers would be a gross and severe understatement.
2024 saw them win the ACC and get back to the CFP after a three-year drought. Unfortunately, 2025 has been a crash back to reality.
While the Tigers have won three straight, one of those games was against Furman, and another was against a Florida State team that looks further and further removed from the squad that took down Alabama.
More concerningly, they lost to Syracuse, Duke and SMU at home.
However, this Clemson team is not bad. In fact, if you remove the preseason expectations, this team has been a little above average with some close losses. Clemson ranks 43rd nationally in PFF's grades and 33rd in our power rankings.
The Tigers have been powered mostly by their passing game, led by Cade Klubnik, who has posted a quietly solid season with an 84 PFF grade. While he is certainly not a Heisman contender or first-round draft prospect, he is an above-average college quarterback.
PFF has the Tigers as the 22nd-best graded passing offense nationally, a stark contrast to their rushing offense, which ranks 118th.
The good news is that they pass the ball a lot more than they run (25th in passing play rate), and it does not affect their ability to move the chains, as they rank 23rd in standard-down rate.
On defense, the Tigers have been even better with the 36th-graded overall defense by PFF. In particular, they excel against the pass and put teams in tough spots.
On defense, the Tigers rank:
- 22nd in passing play success rate allowed.
- 45th in pass play PPA/play allowed.
- 22nd in defensive havoc.
This has culminated in Clemson ranking 10th in standard-down rate, forcing opponents into long-yardage situations.
The Tigers have excelled at getting offenses off the field, ranking 10th in 3rd-down defense.
South Carolina Gamecocks Betting Preview: Stuck in Neutral
Despite relatively high hopes entering the season, this most recent installment of Beamer Ball has been a tough one for the Gamecocks.
After starting 1-6 in the SEC with five losses by double digits or more, South Carolina dropped the biggest dud of a second half, maybe in the history of the SEC (please don’t verify this claim), in a loss to Texas A&M.
The second half of that game has been the story of the year for Beamer and his crew. Despite forcing four turnovers, they could not build a large enough lead, with the offense scoring just two touchdowns.
LaNorris Sellers has had a rough season, ranking 78th in PFF grade among quarterbacks who have taken at least 260 dropbacks this season. The passing offense has sputtered, ranking:
- 113th in pass play success rate.
- 109th in pass play PPA/play.
- 15th in pass play rate.
So, South Carolina has thrown the ball a lot this season, but it hasn't been good at it. This is backed up by its 77th-graded passing offense by PFF.
All this passing — and the little success the Gamecocks have had doing it — has led to struggles staying in front of the chains, ranking 122nd in standard-down rate.
Clemson vs South Carolina Pick, Betting Analysis
While both teams have to be disappointed with their season, a win here will at least somewhat redeem 2025 in the eyes of their respective fanbases.
Preseason, this was circled as a game that could decide the Heisman. I mean, look at those preseason Heisman odds! Maybe Vegas doesn’t know anything!
Levity aside, I really have no idea why South Carolina is favored in this game.
I think Clemson matches up extremely well with the Gamecocks. Most of Clemson’s strengths (pass defense, pressure) align directly with South Carolina’s weaknesses.
I expect Sellers to struggle again against a good pass defense. Look for him to hold onto the ball, panic, and try to make something out of nothing. While that’s worked for him in the past, it has not this season.
South Carolina will end up in plenty of 3rd-and-long situations — and the Gamecocks don’t convert those.
I’m not saying Clemson is going to steamroll South Carolina, but in my opinion, the wrong team is favored here.
I like the Tigers to win outright and put the final nail in the coffin of Beamer Ball.
Pick: Clemson ML (+120, bet365)
Clemson vs South Carolina Betting Trends
