Saturday’s College Football Odds & Sharp Betting Picks: Predictions for Notre Dame vs. Virginia Tech, More Week 6 Games

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Photo by Lee Coleman/Icon Sportswire via Getty Images. Pictured: Virginia Tech Hokies wide receiver Jaden Payoute

PJ Walsh

Updated:

Oct 09, 2021, 01:06 PM EDT

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Notre Dame vs. Virginia Tech leads a loaded Saturday Week 6 slate of college football sharp betting picks.
Saturday's best college football bets also include a handful of smaller matchups, like Old Dominion vs. Marshall and SMU vs. Navy.
Below we examine the top college football betting predictions for Saturday's schedule of games.

Talk about a variety of betting angles for Saturday's college football Week 6 slate.

We have big games, like Notre Dame vs. Virginia Tech, showing a big betting edge, and matchups that won't interest most fans and casual bettors, like Old Dominion vs. Marshall, attracting oodles of smart money from the wiseguys.

And to make it even more interesting, there's also windy weather forecasted across the country, bringing our highly-profitable Windy Unders PRO Betting System back into play.

With the luxury of our college football PRO tools and data, let's break down the four smartest bets from Saturday's Week 6 slate.