The Houston Cougars (4-0, 1-0 Big 12) host the No. 11 Texas Tech Red Raiders (4-0, 1-0 Big 12) in an in-state battle on Saturday night. in Houston, Texas. Kickoff is set for 7 p.m. ET on ESPN.
The Red Raiders come into this game as 13.5-point favorites over the Cougars, who are +350 on the moneyline to pull off the upset. The over/under sits at 51.5 total points.
I put together a 2-leg parlay, including a spread pick and a player prop for Houston quarterback Conner Weigman.
Let's take a look at the Texas Tech vs. Houston odds and my college football picks for Saturday, October 4.
Houston vs Texas Tech Odds
| Houston Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+13.5 -110 | 51.5 -110o / -110u | +350 |
| Texas Tech Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-13.5 -110 | 51.5 -110o / -110u | -500 |
Houston vs Texas Tech Picks
- Texas Tech -12.5
- Conner Weigman 160+ Passing Yards
Same-Game Parlay Odds: +186 (via DraftKings)
Spread Pick: Texas Tech -12.5
We’re riding with the road favorite in this Big 12 showdown, as Texas Tech has emerged as one of the biggest surprises of the 2025 season.
The Red Raiders offense has been dynamic, putting up at least 34 points in all four of their games so far. That level of production makes them tough to keep pace with.
Houston, meanwhile, has looked like a below-average offensive team and will likely struggle to move the ball consistently against this opponent.
All signs point to Tech continuing its strong run with another convincing performance.
Houston Player Prop: Conner Weigman 160+ Passing Yards
Weigman, the former Texas A&M signal-caller, finds himself in a favorable game script to hit this prop.
With Houston likely playing from behind for much of the contest, Weigman should be asked to air it out frequently.
He has already cashed this prop in three of his four outings this season, and the lone miss came when he finished with 159 yards against Stephen F. Austin in Week 1 — just shy of the mark.
Given the expected game flow, Weigman looks well-positioned to deliver again.
This parlay pays out at nearly 2-1, so we'll back Texas Tech to get it done while Weigman chucks the ball around the field in an attempt to keep up.
Houston vs Texas Tech Same-Game Parlay
- Texas Tech -12.5
- Conner Weigman 160+ Passing Yards
Same-Game Parlay Odds: +186 (via DraftKings)
