The Iowa State Cyclones take on the Oklahoma State Cowboys in Stillwater, Oklahoma, on Saturday, Nov. 29. Kickoff is set for 12 p.m. ET on ESPNU.
Iowa State is favored by 14 points on the spread with a moneyline of -600. Oklahoma State, meanwhile, enters as a +14 underdog and is +450 on the moneyline to pull off the upset. The over/under sits at 46.5 total points.
Here’s my Iowa State vs. Oklahoma State prediction and college football picks for Saturday, November 29.
Iowa State vs Oklahoma State Prediction
- Iowa State vs. Oklahoma State Pick: Oklahoma State +14.5
My Oklahoma State vs. Iowa State best bet is on the Cowboys to cover the spread. Find the best line available on our live NCAAF odds page.
Iowa State vs Oklahoma State Odds
| Iowa State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-14 -110 | 46.5 -110o / -110u | -600 |
| Oklahoma State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+14 -110 | 46.5 -110o / -110u | +450 |
- Iowa State vs Oklahoma State Spread: Iowa State -14, Oklahoma State +14
- Iowa State vs Oklahoma State Over/Under: 46.5 Points
- Iowa State vs Oklahoma State Moneyline: Iowa State -600, Oklahoma State +450
Iowa State vs Oklahoma State College Football Betting Preview
Iowa State Cyclones Betting Preview: Not the Same Team
Iowa State concludes what will amount to a disappointing season on the road this week following back-to-back wins over TCU and Kansas.
The Cyclones struggled through a four-game losing streak earlier in the season that saw the defense evaporate while surrendering 450 yards. At the same time, the offensive production couldn't keep up.
Quarterback Rocco Becht has seen his passing production decrease from last season. Iowa State doesn't have as much explosiveness in the receiver room, and the Clones have called a much more conservative game plan this season.
With running back Carson Hansen likely out, this appears to be another blow to an offense that already has been struggling with continuity.
Defensively, Iowa State has played pretty well at times, but this is still a below-average P4 defense that grades out in the bottom half of the Big 12 in most defensive metrics.
The Cyclones have struggled with missed tackles, and the secondary has sustained injuries that have affected pass coverage.
Iowa State has struggled to generate Havoc and negative plays this season. With all of the injuries that have piled up, it's hard to see this defense being a force on the road in the season finale.
Oklahoma State Cowboys Betting Preview: Not Quitting Yet
Oklahoma State has struggled through a disastrous season, which has seen the Cowboys play hard but fall short time and again while notching just one win.
The Cowboys have battled tough despite injuries and a coaching change. They haven't quit on the season and have played hard the last two weeks against Kansas State and UCF.
The offense doesn’t have a ton of zest, but it's starting to come together with Zane Flores at quarterback. Too little, too late for 2025, but I expect this group to play hard in the season finale at home.
The Cowboys defense has struggled all season, as it's often overmatched and lacks the talent necessary to compete in the Big 12.
We saw this unit get shredded consistently against most of its conference opponents, but the performance on the field has been better the last couple of weeks.
To their credit, the Pokes are still playing really hard on defense, and they did well to stifle Kansas State and UCF in their last two games.
I expect OK State to play hard here. It should have some success against an Iowa State offense that struggles to generate explosives.
Iowa State vs Oklahoma State Pick, Betting Analysis
This line seems too high for me, and I'm going to be rolling with the home 'dog in this one.
Oklahoma State has actually played really inspired football over the last two weeks, and I believe it will remain competitive here.
The offense outgained Kansas State by nearly 100 yards in its last home game and had several chances to score but couldn’t scratch one across.
The season-long metrics aren't going to love the offense, but OK State has run for 4.5 yards per carry in the last two weeks.
Iowa State has struggled all season against the run and ranks just 104th nationally in yards per rush allowed on defense. The Cyclones also allow quite a bit of explosiveness on the ground, and I expect freshman running back Rodney Fields Jr. to have a big day on the ground for the Cowboys.
Iowa State isn't going to generate a lot of Havoc defensively, ranking just 67th in that area on the season. The defensive front has logged just 10 sacks on the season.
I believe Oklahoma State can handle the pass rush and give Flores some time to throw the ball. Given the injuries and poor performance of the Iowa State secondary, I think Oklahoma State will have success moving the ball through the air.
Iowa State isn't a big-play offense, ranking just 108th nationally in explosiveness. The Cyclones struggle to throw the ball and suffered a big blow last week when Hansen went down with a lower leg injury. He's unlikely to play in this one.
I expect a diminished production level in the run game with minimal explosiveness out of the Cyclones.
The spot is tough for Iowa State, as it's not really playing for much here in its season finale.
I think Oklahoma State will be juiced up and ready to go at home. I think it can do enough to not only cover this inflated number, but I expect this game to be close and competitive into the fourth quarter.
Grab the generous amount of points with your generous second helping of Thanksgiving leftovers, and settle in for a fun Big 12 game.
Pick: Oklahoma State +14.5
Iowa State vs Oklahoma State Betting Trends
