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The James Madison Dukes take on the Old Dominion Monarchs in Norfolk, VA. Kickoff is set for 6 p.m. ET on ESPN+.
James Madison is favored by -6 points on the spread with a moneyline of -225. The total is set at 45.5 points.
Here’s my James Madison vs. Old Dominion prediction and college football pick for Saturday, September 26, 2026.
James Madison vs Old Dominion Prediction
- James Madison vs. Old Dominion Pick: Over 44.5
My Old Dominion vs. James Madison best bet is on the over. Find the best line available on our live NCAAF odds page.
James Madison vs Old Dominion Odds
| James Madison Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-6 -115 | 45.5 -102o / -118u | -225 |
| Old Dominion Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+6 -108 | 45.5 -102o / -118u | +185 |
- James Madison vs Old Dominion point spread: James Madison -6 (-115), Old Dominion +6 (-108)
- James Madison vs Old Dominion over/under: 45.5 (-102o / -118u)
- James Madison vs Old Dominion moneyline: James Madison -225, Old Dominion +185
James Madison vs Old Dominion Pick, Betting Analysis
In Year 1 of the Billy Napier experiement, James Madison puts its 3-0 record on the line on the road at Old Dominion this weekend. The good news is the Dukes already have proven they can get the job done on the road, as they won outright as a three-point 'dog in a cross-country game at San Diego State.
Meanwhile, Old Dominion hasn't done anything noteworthy, beating Norfolk State, allowing 41 points to Virginia Tech, and then losing to East Carolina at home.
But our very own Evan Abrams has a reliable Bet Labs Sports Insights system — "Beware of Falling Totals" — that isn't targeting a side in this game. In fact, this system — which holds a 4% return on investment (ROI) all-time and a 24% ROI this season alone — says that the over is the play.
In both regular season and postseason college football, significant drops in the total from opening to closing lines often reflect heavy betting on the under, usually driven by weather concerns, injuries, or perceived matchup issues.
However, these moves can sometimes overstate the expected scoring decline, creating value on the over.
When the adjustment is meaningful but not extreme, offenses can still exceed the lowered expectation, particularly if conditions improve or if the line movement was influenced by public overreaction rather than substantial changes to game dynamics.
This game qualifies, and that's why we're backing this reliable system.
Pick: Over 44.5
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