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Notre Dame vs. Ohio State Odds Week 1: Picks & Predictions for Saturday Night’s Top-5 Showdown

Notre Dame vs. Ohio State Odds Week 1: Picks & Predictions for Saturday Night’s Top-5 Showdown article feature image
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Photo by Emilee Chinn/Getty Images. Pictured: C.J. Stroud #7 of the Ohio State Buckeyes and his teammates take the field

Notre Dame vs. Ohio State Odds

Notre Dame Odds +16
Ohio State Odds -16
Over/Under 59
Date Saturday, Sept. 3
Time 7:30 p.m. ET
Channel ABC

*Odds as of Saturday morning

Talk about a monster college football matchup right out of the gates.

Saturday’s loaded college football Week 1 slate is already filled with in-state rivalry games and matchups between top-25 teams, but No. 5 Notre Dame vs. No. 2 Ohio State certainly takes the cake in terms of the most highly-anticipated game of the day.

While both teams are currently ranked among the AP’s top five, the latest Notre Dame vs. Ohio State odds make this game even more interesting.

The Fighting Irish are massive 16-point underdogs against the Buckeyes on Saturday night, making Notre Dame the third-largest underdog since 2000 among teams ranked in the AP’s top five.

I know, cool stat and all, but what does that mean for college football bettors?

Thanks for asking that very question, because the Action Network’s college football picks and predictions provide a very clear answer.

Notre Dame vs. Ohio State Pick

There’s no doubt that this is a huge spread for Ohio State to cover against a top-five opponent.