The Ohio Bobcats take on the Buffalo Bulls in Buffalo, New York. Kickoff is set for 12:00 p.m. EST on ESPNU.
Ohio is favored by 7 points on the spread with a moneyline of -260. The total is set at 44.5 points.
Here’s my Ohio vs. Buffalo prediction and college football picks for Friday, November 28, 2025.
Ohio vs Buffalo Prediction
- Ohio vs. Buffalo Pick: Buffalo ML (+210, bet365)
My Buffalo vs. Ohio best bet is on the Bulls to win outright. Find the best line available on our live NCAAF odds page.
Ohio vs Buffalo Odds
| Ohio Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-7 -110 | 44 -110o / -110u | -260 |
| Buffalo Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+7 -110 | 44 -110o / -110u | +210 |
- Ohio vs Buffalo point spread: Ohio -7 (-110), Buffalo +7 (-110)
- Ohio vs Buffalo over/under: 44.5 (-110o / -110u)
- Ohio vs Buffalo moneyline: Ohio -260, Buffalo +210
Ohio vs Buffalo Preview
This game triggered one of our Action PRO systems, powered by Evan Abrams.
In college football, contrarian underdogs thrive when the betting line moves against them.
When spreads shift by several points from open to close, it often reflects heavy public or sharp money fading the dog, inflating the line, and creating hidden value on the moneyline.
In games where the spread is moderate to large, between four and just over 13, these underdogs are often overlooked but capable of outright wins.
The inflated perception of the favorite can lead to mispriced odds, and the contrarian angle looks to capitalize on those rare moments when the market has overcorrected.
Underdogs that fit the system this season are 35-58 outright, a 38% win rate generating a 28% ROI.
Pick: Buffalo ML (+210, bet365)
