The Oklahoma Sooners take on the Michigan Wolverines in Ann Arbor, Michigan, on Saturday, Sept. 12. Kickoff is set for 12 p.m. ET on FOX.
Oklahoma is favored by -5.5 points on the spread with a moneyline of -225. Michigan, meanwhile, enters as a +5.5 underdog and is +185 on the moneyline to pull off the upset. The over/under sits at 43.5 total points.
Here’s my Oklahoma vs. Michigan prediction and college football pick for Saturday, September 12.
Oklahoma vs Michigan Prediction
- Oklahoma vs. Michigan Pick: Oklahoma -5.5 or Better
My Michigan vs. Oklahoma best bet is on the Sooners to cover the spread. Find the best line available on our live NCAAF odds page.
Oklahoma vs Michigan Odds
| Oklahoma Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-5.5 -110 | 43.5 -110o / -110u | -225 |
| Michigan Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+5.5 -110 | 43.5 -110o / -110u | +185 |
- Oklahoma vs Michigan Spread: Oklahoma -5.5 (-110), Michigan +5.5 (-110)
- Oklahoma vs Michigan Over/Under: 43.5 (-110o / -110u)
- Oklahoma vs Michigan Moneyline: Oklahoma -225, Michigan +185
Oklahoma vs Michigan College Football Preview
Oklahoma Sooners Betting Preview: Healthy and Rolling
Despite triple-digit temperatures, Oklahoma barely broke a sweat in a 51-0 opening victory against UTEP. The Sooners flexed on defense, keeping the Miners under three yards per carry while also limiting the visitors to just two third-down conversions.
Linebacker Reggie Powers III led all Oklahoma defenders in tackles. UTEP was inept on passing plays, as OU allowed a 24% Success Rate on 21 attempts.
For Oklahoma, the bigger news was full health at the quarterback position on the other side of the ball.
John Mateer returns to full strength after a 2025 hand injury plagued the quarterback through the second half of the season. The super senior connected on 11-of-17 attempts for three touchdowns, finding Isaiah Sategna III more than any other target on the Sooners' roster.
The former Arkansas wide receiver not only found the end zone in the passing game, but also continued to be one of the most dangerous special teams players in FBS with an 88-yard punt-return touchdown.
Michigan Wolverines Betting Preview: Plenty to Improve
The biggest question from the clock fiasco in Ann Arbor comes with Michigan's near future in the coming weeks.
Head coach Kyle Whittingham has quarterback Bryce Underwood on a short leash heading into Week 2, as the sophomore posted an interception and fumble in the thriller over Western Michigan.
Underwood logged five turnover-worthy plays in Week 1 after posting a total of 15 last year. Western Michigan recorded pressure on just 6-of-23 dropbacks, recording one sack the entire game.
Without any drops by Michigan's receivers, Underwood was fully responsible for the two turnovers and six other drives that ended in a punt.
The Wolverines did their job in the opener against Western Michigan, allowing just 12 points on four field goals. The Broncos averaged 3.3 yards per play and failed to create an explosive drive.
Troy Bowles led the way with nine tackles, while Dom Nichols produced two sacks off four pressures.
However, there are areas that need to be improved against Oklahoma. Michigan failed to create Havoc, stuffing Western Michigan on just 25% of its 44 rushing attempts.
The Wolverines' secondary also failed to produce a pass breakup, while three of Western Michigan's fumbles weren't recovered by Michigan.
Oklahoma vs Michigan Pick, Betting Analysis
Oklahoma and Michigan have been in the Game of the Year market for months, with a spread close to a pick'em.
Thanks to the Wolverines' near-loss to WMU in Week 1, this number reached as high as Oklahoma -6.5 before a buyback occurred in the market.
The biggest question in this game is if a one-game sample set is enough to move the number that far.
Action Network, SP+ and Sagarin all call for Oklahoma to be a minimum touchdown favorite in the Big House.
Underwood's five turnover-worthy plays could get Michigan in deep waters against an aggressive Oklahoma defense that should be a national leader in Success Rate allowed and Havoc by the end of the season.
If Underwood were to have a clean sheet at the end of the game, the remaining pieces of the Michigan offense must step up. Slot receiver JJ Buchanan may provide that relief, generating six targets from Underwood in Week 0.
Buchanan caught 3-of-4 contested throws from Underwood, signaling that Michigan may run some quick slants to the slot early in this game.
Michigan's rushing game was also subpar against Western Michigan. Running back Jordan Marshall tallied 44 yards on 11 carries. The fourth-year rusher forced only two missed tackles on the day while posting a horrid 1.8 yards after first contact.
There's reason to believe the Oklahoma defense will key in on Underwood's mobility while sitting in Brent Venables' Cover 3 schemes.
On the other side of the ball, Michigan's lack of Havoc might allow Mateer to execute outside the pocket. The Wolverines posted just two sacks on Western Michigan, and a much tougher offensive line and mobile quarterback await with Oklahoma.
The Broncos held the ball more than 40 minutes of possession in Week 1, an advantage the Oklahoma offense can recreate through a deep running back stable.
There's justification in all areas for Oklahoma to make a leap on the spread for this game.
First, the Michigan defense had no teeth in creating Havoc against Western Michigan. Second, the Oklahoma offense is a much more cohesive unit, with three players catching touchdown passes and four different rushers creating explosive runs.
Michigan won't get enough out of Marshall on the ground, while Buchanan is the only verified target for Underwood.
Finally, special teams goes to Oklahoma, as Sategna is a threat to score on any kickoff or punt return.
Pick: Oklahoma -5.5 or Better
Oklahoma vs Michigan Betting Trends
