The Ole Miss Rebels take on the Mississippi State Bulldogs in Starkville on Friday, Nov. 28. Kickoff is set for 12 p.m. ET on ABC.
Ole Miss is favored by 7 points on the spread with a moneyline of -270. Mississippi State, meanwhile, enters as a +7 underdog and is +220 on the moneyline to pull off the upset. The over/under sits at 62.5 total points.
Here’s my Ole Miss vs. Mississippi State prediction and college football picks for Friday, November 28.
Ole Miss vs Mississippi State Prediction
- Ole Miss vs. Mississippi State Pick: Ole Miss -7 · Chambliss Over 46.5 Rushing Yards
My Mississippi State vs. Ole Miss best bet is on the Rebels to cover the spread and quarterback Trinidad Chambliss to go over his rushing yards prop. Find the best line available on our live NCAAF odds page.
Ole Miss vs Mississippi State Odds
| Ole Miss Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-7 -110 | 62.5 -110o / -110u | -270 |
| Mississippi State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+7 -110 | 62.5 -110o / -110u | +220 |
- Ole Miss vs Mississippi State Spread: Ole Miss -7, Mississippi State +7
- Ole Miss vs Mississippi State Over/Under: 62.5 Points
- Ole Miss vs Mississippi State Moneyline: Ole Miss -270, Mississippi State +220
Ole Miss vs Mississippi State College Football Betting Preview
Ole Miss Rebels Betting Preview: More Off-Field Waves
There may not be a college football rivalry with as many off-field waves as the Egg Bowl.
The noise outside of the game this season is the status of head coach Lane Kiffin, as the Ole Miss athletic director will force a decision from his head coach after Week 14.
There's plenty on the line for Mississippi, including a birth in the College Football Playoff.
Ole Miss has fielded one of the best offenses in the nation, led by Ferris State transfer quarterback Trinidad Chambliss. The sophomore has a 14:3 touchdown-to-interception ratio, more than doubling his big-time throws versus turnover-worthy plays.
Despite the loss of the best Havoc defense in 2024, the Rebels retooled in 2025 to produce one of the best pass defenses in the nation.
Defensive coordinator Pete Golding has fielded ranks in the top 20 with respect to pass efficiency and EPA allowed. The nickel defense plays with plenty of numbers at the second level with quarters and Cover 3 zone.
The defense does have issues with offenses capable of running the ball, particularly against inside zone run concepts with a light box.
Mississippi State Bulldogs Betting Preview: Looking for Egg Bowl Upset
Mississippi State has a chance to go to bowl season with a victory over rival Ole Miss in what would be a major leap forward for head coach Jeff Lebby.
The Bulldogs have played a tight conference schedule with one-possession losses to Tennessee, Florida and Texas.
This has been a run-first offense behind running backs Davon Booth and Fluff Bothwell. Zone read serves as the primary concept for the ground game, but Miss State averages more success and explosives with inside zone.
Mississippi State has had more success creating explosives through the air, especially in passing downs, with a rank of seventh in EPA.
Lebby's offense has not been able to sustain methodical drives, but it does have one of the highest numbers nationally in points per scoring attempt. In 62 offensive possessions to cross the opponent's 40-yard line, Mississippi State averages 4.6 points.
The defense has been a point of contention during conference play, fielding one of the lowest numbers in defending the rush and generating pressure on the quarterback.
The Bulldogs rank bottom-10 in opponent rush efficiency, Line Yards and rush explosives allowed. Mississippi State has struggled against man blocking concepts with just a 39% Success Rate.
Ole Miss vs Mississippi State Pick, Betting Analysis
There should be no resistance from Mississippi State when it comes to Ole Miss' ground attack.
In recent games, the Bulldogs gave up 9.4 yards per play to Missouri on the ground and previously allowed 6.9 yards per play on 44 rushing attempts against Georgia.
Ole Miss' second-heaviest run concept usage is man blocking, recording a 63% Success Rate with an explosive on one of every 10 attempts.
The biggest benefactor of that concept is Chambliss, who has cranked out 334 yards on designed runs this season. The quarterback has had limited designed rush attempts the past two weeks after attempting 27 in the previous two weeks against South Carolina and Oklahoma.
Chambliss' rushing prop should be under review for an over.
Mississippi State should have similar success on the ground with zone read, as Ole Miss has a tepid Success Rate of 45% against the concept.
The difference on this side of the ball is the Rebels' tackling at the second level. Ole Miss ranks 21st in PFF tackling, and that number improves to 14th in broken tackles allowed.
The Action Network projection calls for Ole Miss to be favored by 8 points with a total of 65.
There's no expectation that Mississippi State will produce a stop against Kiffin's offense, particularly when Chambliss has designed run attempts.
Look for the Rebels to take the Egg Bowl by a touchdown or more just before the fireworks begin within the coaching staff.
Pick: Ole Miss -7 or Better · Chambliss Over 46.5 Rushing Yards
Ole Miss vs Mississippi State Betting Trends
