Sunday afternoon's NFC clash in Arlington has the 7-1 49ers at 4-5 Dallas, and this 49ers vs. Cowboys prediction rounds up our best NFL Week 10 player props from the live Polymarket board.
- San Francisco is a 4.5-point favorite on the spread and sits at 66% on the moneyline, with the total at 55.5.
- Keenan Allen makes his 49ers debut after a midweek trade, Deebo Samuel is cleared to return, and Dallas is without tight end Jake Ferguson.
Here is our full picks table before we break down every pick, the game lines, and the player prop boards for 49ers vs. Cowboys.
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Est. Return on $100 | 📈 Trade It |
|---|---|---|---|
| Javonte Williams 1+ Anytime Touchdowns | Yes | 60¢ | $166.67 | Trade it on Polymarket! |
| Brevyn Spann-Ford 20+ Receiving Yards | Yes | 59¢ | $169.49 | Trade it on Polymarket! |
| Brock Purdy 250+ Passing Yards | Yes | 58¢ | $172.41 | Trade it on Polymarket! |
| Keenan Allen 20+ Receiving Yards | Yes | 58¢ | $172.41 | Trade it on Polymarket! |
| Dak Prescott 275+ Passing Yards | Yes | 52¢ | $192.31 | Trade it on Polymarket! |
| Over 55.5 Total Points | Yes | 52¢ | $192.31 | Trade it on Polymarket! |
| CeeDee Lamb 90+ Receiving Yards | Yes | 51¢ | $196.08 | Trade it on Polymarket! |
| 49ers -4.5 Spread | Yes | 48¢ | $208.33 | Trade it on Polymarket! |
| Christian McCaffrey 2+ Anytime Touchdowns | Yes | 33¢ | $303.03 | Trade it on Polymarket! |
49ers vs. Cowboys Prediction: Best NFL Player Props on Polymarket
Every pick below is a real trade we'd make after redeeming the Polymarket promo code ACTION, part of our best NFL player props for this matchup, ranked from the highest price down to the long shot. Looking for more options? See the NFL prediction market promos and the best prediction market apps.
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Best Anytime Touchdown Prop Today – Javonte Williams 1+ Touchdown
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Est. Return on $100 | 📈 Trade It |
|---|---|---|---|
| Javonte Williams 1+ Anytime Touchdowns | Yes | 60¢ | $166.67 | Trade it now on Polymarket! |
Tyler Goodson is out for Dallas, and Javonte Williams and fullback Hunter Luepke are the only healthy backs on the roster, per Footballguys. That puts the carries and the goal-line looks on Williams.
He ran 20 times for 101 yards and a score in the 27-23 win over the Colts last Sunday, and the Cowboys are home with the ball in a game that carries a 55.5-point total.
At a 60¢ price, a $100 buy works out to roughly 167 shares, and the estimated return is $166.67.
- If Williams scores a touchdown: Return of $166.67.
- If not: the $100 stake is a total loss.
Priced like a 60% shot, and the return still tops $1.60 for every dollar.
Best Receiving Yards Prop Today – Brevyn Spann-Ford 20+ Yards
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Est. Return on $100 | 📈 Trade It |
|---|---|---|---|
| Brevyn Spann-Ford 20+ Receiving Yards | Yes | 59¢ | $169.49 | Trade it now on Polymarket! |
Dallas listed tight end Jake Ferguson as out with an ankle and knee injury, so the tight end targets need a new home.
Twenty yards is a low bar in a game the market expects to be a shootout, and Dak Prescott threw for 335 yards last week.
At a 59¢ price, a $100 buy works out to roughly 169 shares, for an estimated return of $169.49.
- If Spann-Ford gets to 20 receiving yards: Return of $169.49.
- If not, the $100 stake is a total loss.
A short number on a shootout board, and it returns about 1.7x.
Best Passing Yards Prop Today – Brock Purdy 250+ Yards
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Est. Return on $100 | 📈 Trade It |
|---|---|---|---|
| Brock Purdy 250+ Passing Yards | Yes | 58¢ | $172.41 | Trade it now on Polymarket! |
San Francisco scores 3.9 touchdowns a game and converts 84.6% of its red zone trips, and both numbers lead the NFL. Dallas has allowed 236 points through nine games.
The Cowboys also list cornerbacks DaRon Bland, Joey Porter Jr., and Devin Moore as questionable, and Deebo Samuel is cleared to return after missing since Week 5.
At a 58¢ price, a $100 buy works out to roughly 172 shares, and the estimated return is $172.41.
- If Purdy throws for 250 or more yards: Return of $172.41.
- If not, the $100 stake is a total loss.
That's a return north of 1.7x on the quarterback of the league's top offense.
Best Receiving Yards Prop Today – Keenan Allen 20+ Yards
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Est. Return on $100 | 📈 Trade It |
|---|---|---|---|
| Keenan Allen 20+ Receiving Yards | Yes | 58¢ | $172.41 | Trade it now on Polymarket! |
Allen makes his 49ers debut after a midweek trade from the Colts, and Kyle Shanahan said Allen has a role in the offense.
Mike Evans is out for a third straight game, so San Francisco needs a veteran slot target, and 20 yards is a modest ask in this offense.
At 58¢, a $100 buy works out to roughly 172 shares, and the estimated return is $172.41.
- If Allen reaches 20 receiving yards: Return of $172.41.
- If not, the $100 stake is a total loss.
A return of about 1.7x on a role that just opened up.
Best Passing Yards Prop Today – Dak Prescott 275+ Yards
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Est. Return on $100 | 📈 Trade It |
|---|---|---|---|
| Dak Prescott 275+ Passing Yards | Yes | 52¢ | $192.31 | Trade it now on Polymarket! |
Prescott went 21 of 34 for 335 yards and two touchdowns last week, and the Cowboys put up more than 500 yards of offense without George Pickens.
Pickens said he'll play this week, and San Francisco has four defensive backs listed as questionable, including corners Renardo Green and Deommodore Lenoir.
At a 52¢ price, a $100 buy works out to roughly 192 shares, with an estimated return of $192.31.
- If Prescott throws for 275 or more yards: Return of $192.31.
- If not: the $100 stake is a total loss.
A near coin-flip price that returns almost 1.9x.
Best Total Pick Today – Over 55.5
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Est. Return on $100 | 📈 Trade It |
|---|---|---|---|
| Over 55.5 Total Points | Yes | 52¢ | $192.31 | Trade it now on Polymarket! |
This is the highest total on a Cowboys game this season. San Francisco leads the league in touchdowns per game, and Dallas has allowed 236 points in nine games.
Dallas also has Pickens back to pair with CeeDee Lamb, so both sides have a path to 28 or more.
At a 52¢ price, a $100 buy works out to roughly 192 shares, and the estimated return is $192.31.
- If the game finishes with 56 or more total points: Return of $192.31.
- If not, the $100 stake is a total loss.
A return of roughly 1.9x on the number the whole board is built around.
Best Receiving Yards Prop Today – CeeDee Lamb 90+ Yards
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Est. Return on $100 | 📈 Trade It |
|---|---|---|---|
| CeeDee Lamb 90+ Receiving Yards | Yes | 51¢ | $196.08 | Trade it now on Polymarket! |
Lamb caught 10 of 16 targets for 195 yards and a touchdown against the Colts, with Pickens sidelined.
Even with Pickens back, Lamb is the clear first read for Prescott, and San Francisco's cornerbacks are banged up.
At a 51¢ price, a $100 buy works out to roughly 196 shares, with an estimated return of $196.08.
- If Lamb clears 90 receiving yards: Return of $196.08.
- If not, the $100 stake is a total loss.
Priced at a coin flip, with a return of nearly 2x.
Best Spread Pick Today – 49ers -4.5
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Est. Return on $100 | 📈 Trade It |
|---|---|---|---|
| 49ers -4.5 Spread | Yes | 48¢ | $208.33 | Trade it now on Polymarket! |
San Francisco is 7-1 with a +79-point differential, while Dallas is 4-5 and has allowed 236 points.
Polymarket has the 49ers at 66% on the moneyline, and the Yes side of this spread pays a little better than even money at 48¢.
At 48¢, a $100 buy works out to roughly 208 shares, and the estimated return is $208.33.
- If San Francisco wins by five or more: Return of $208.33.
- If not: the $100 stake is a total loss.
A return of about 2.1x on the side with the better team.
Best Anytime Touchdown Prop Today – Christian McCaffrey 2+ Touchdowns
| 🏈 NFL Prediction | 🏷️ Position | Price | 🤑 Est. Return on $100 | 📈 Trade It |
|---|---|---|---|
| Christian McCaffrey 2+ Anytime Touchdowns | Yes | 33¢ | $303.03 | Trade it now on Polymarket! |
The 49ers lead the league in red zone conversion at 84.6%, and McCaffrey is the back they trust near the goal line.
A 55.5-point total gives him room for a multi-score day against a defense that has allowed 236 points in nine games.
At a 33¢ price, a $100 buy works out to roughly 303 shares, and the estimated return is $303.03.
- If McCaffrey scores two or more touchdowns: Return of $303.03.
- If not: the $100 stake is a total loss.
A longer shot, but the return is more than 3x your stake.
49ers vs. Cowboys Moneyline
Before the player props, here is where this 49ers vs. Cowboys prediction stands on the base game lines.
San Francisco 49ers Moneyline
San Francisco is the road favorite at 66% to win outright, a 7-1 team that leads the NFL in scoring touchdowns per game.
Dallas Cowboys Moneyline
Dallas is the home underdog at 34% to win outright, with a 2.94x payout on the Yes side.
Spread and Total for 49ers vs. Cowboys
49ers vs. Cowboys Spread
San Francisco to win by more than 4.5 points is priced at 48% Yes against 53% No, so the market treats this number as close to a pick'em.
49ers vs. Cowboys Total
The total sits at 55.5 points, priced at 52% Yes on the over against 48% No on the under.
What's Moving the Market?
Prediction markets and prices can move for several reasons. Pickens' price fell eight points to 53% on the receiving yards board, while Keenan Allen is up six points to 58% on his 20-yard number.
Deebo Samuel's anytime touchdown price dropped seven points to 34%, and Jordan Watkins and George Kittle also moved down on their boards. We can't say what drove any of those moves.
The board also lines up with the injury news. Mike Evans is out for San Francisco, Jake Ferguson is out for Dallas, and both teams have defensive backs listed as questionable, so check final inactives before kickoff.
How to Trade These 49ers vs. Cowboys Picks on Polymarket
Ready to get in on these NFL Week 10 picks yourself? Here's how to claim the bonus and start trading:
- Read a comprehensive Polymarket review to understand how this exchange operates.
- Follow this guide to trading on Polymarket to learn how to buy your first "Yes" or "No" contract.
- Monitor the relevant tab on Polymarket to stay ahead of live order-book movements.
- When you're ready, sign up with Polymarket promo code ACTION, deposit $10, and get a $25 bonus to get started!
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Final Thoughts: 49ers vs. Cowboys Prediction for NFL Week 10
San Francisco has the better record, the league's top scoring offense, and a Dallas defense that has allowed 236 points through nine games. That's why our picks lean on the 49ers' side, the over, and passing yards on both sides.
That wraps our 49ers vs. Cowboys prediction and every NFL player prop we'd trade on the Polymarket board. For more on how these markets work, check the prediction markets hub, and see how they compare in NFL prediction market vs. sportsbook. You can also check the latest NFL odds before kickoff.
Polymarket Promo Code FAQs
What is the Polymarket promo code for the 49ers vs. Cowboys game?
The current Polymarket promo code is ACTION. New users who sign up with it can deposit $10 and get a $25 bonus to use on NFL Week 10 markets.
Who wins the 49ers vs. Cowboys prediction?
The Polymarket board favors San Francisco at 66% to win outright, and the 49ers are 4.5-point favorites on the spread.
What are the best NFL player props for 49ers vs. Cowboys?
Our picks lean on Javonte Williams to score, Brock Purdy to reach 250 passing yards, and Keenan Allen to reach 20 receiving yards.
What are the best anytime TD scorer predictions for 49ers vs. Cowboys?
Javonte Williams is the highest-priced anytime touchdown pick at 60%, followed by CeeDee Lamb at 51% and George Kittle at 45%.
What time does 49ers vs. Cowboys kick off?
Kickoff is at 4:25 p.m. ET on Sunday, Nov. 15, at AT&T Stadium in Arlington, Texas, and the game airs on FOX.
What does the Return column in the picks table mean?
It shows the estimated return on a $100 trade if the pick wins, including your original stake, based on the listed price. Actual fills can differ slightly with order book depth.
How do Polymarket NFL contracts resolve?
Each contract resolves Yes if the stated condition is met in the final game stats and No if it isn't. Each share pays $1 when your side wins and nothing when it doesn't.
