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Chargers vs. 49ers Odds & Betting Predictions - August 23, 2025

Chargers at 49ers

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Los Angeles Chargers

0-1
@

San Francisco 49ers

6-11

Chargers at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Chargers
0-1
N/A
N/A
N/A
49ers
6-11
N/A
N/A
N/A
location pinSaturday 4:00 p.m.
August 23, 2025
Levi's StadiumSanta Clara

Chargers vs. 49ers Props

Prop Projections

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Chargers vs. 49ers Public Betting Percentages

Away Logo

Chargers

Public

Home Logo

49ers

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • 49ers are 2-3 in their last 5 games.
  • 49ers are 2-3 in their last 5 games against the spread
  • 49ers are 1-7 in their road games against the spread
  • The totals have gone OVER in 2 of 49ers' last 5 games
  • The totals have gone OVER in 5 of 49ers' 9 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers		5-124-51-75-80-4
Chargers		12-4-15-2-17-211-21-2-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers		10-75-45-37-63-1
Chargers		8-95-33-67-61-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers		6-11N/AN/A6-70-4
Chargers		11-6N/AN/A11-20-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jan 5th@ARIL 24-47+5.5 LO 43.5ARI +195
Dec 31stDETL 34-40+4 LO 50.5DET +182
Dec 22nd@MIAL 17-29-1.5 LO 44MIA -125
Dec 13thLAL 6-12-3 LU 48.5LA -155
Dec 8thCHIW 38-13-3 WO 43.5SF -163

49ers vs. Chargers Injury Updates

49ers Injuries

  • Trent Williams
    T

    Williams is out with ankle

    Out

  • Christian McCaffrey
    RB

    McCaffrey is out with knee

    Out

  • George Kittle
    TE

    Kittle is questionable with ankle

    Questionable

  • George Odum
    S

    Odum is out with knee

    Out

  • Greg Joseph
    K

    Joseph is out with abdomen

    Out

  • Kevin Givens
    DE

    Givens is questionable with groin

    Questionable

  • Andre Dillard
    OL

    Dillard is questionable with concussion

    Questionable

  • Mitch Wishnowsky
    P

    Wishnowsky is out with back

    Out

  • Brandon Aiyuk
    WR

    Aiyuk is out with leg

    Out

  • Colton McKivitz
    OL

    McKivitz is questionable with knee

    Questionable

  • Ben Bartch
    OL

    Bartch is out with ankle

    Out

  • Deommodore Lenoir
    DB

    Lenoir is out with shoulder

    Out

  • Spencer Burford
    OL

    Burford is out with calf

    Out

  • Brock Purdy
    QB

    Purdy is out with elbow

    Out

  • Ji'Ayir Brown
    S

    Brown is questionable with ankle

    Questionable

  • Robert Beal
    DE

    Beal is out with ankle

    Out

  • Darrell Luter
    CB

    Luter is doubtful with pelvis

    Doubtful

  • Renardo Green
    DB

    Green is questionable with neck

    Questionable

Chargers Injuries

  • Denzel Perryman
    LB

    Perryman is questionable with groin

    Questionable

  • Tyler Conklin
    TE

    Conklin is questionable with calf

    Questionable

  • Trey Pipkins
    T

    Pipkins is questionable with oblique

    Questionable

  • Jalen Reagor
    WR

    Reagor is out with finger

    Out

  • Alohi Gilman
    S

    Gilman is questionable with hamstring

    Questionable

  • Elijah Molden
    CB

    Molden is questionable with knee

    Questionable

  • Naquan Jones
    DT

    Jones is questionable with elbow

    Questionable

  • Ja'Sir Taylor
    DB

    Taylor is doubtful with oblique

    Doubtful

  • Deane Leonard
    DB

    Leonard is questionable with hamstring

    Questionable

  • Quentin Johnston
    WR

    Johnston is questionable with thigh

    Questionable

  • Junior Colson
    LB

    Colson is questionable with ankle

    Questionable

  • Brenden Rice
    WR

    Rice is out with shoulder

    Out

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Brock Purdy logo
    Brock Purdy
    3864
    pyds
  • passing touchdowns
    Brock Purdy logo
    Brock Purdy
    20
    ptd
  • rushing yards
    player logo
    -
    789
    ryds
  • rushing touchdowns
    Brock Purdy logo
    Brock Purdy
    5
    rtd
Depth Charts
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Starter2ND3RD4TH
QBBrock PurdyJoshua DobbsBrandon AllenTanner Mordecai
RBChristian McCaffreyElijah MitchellJordan MasonPatrick Taylor
WRJauan JenningsJacob CowingTrent Taylor
TEGeorge KittleEric SaubertBrayden WillisJake Tonges
LTJaylon MooreSebastian GutierrezIsaac Alarcon
LGAaron BanksSpencer BurfordNick Zakelj
CJake BrendelBen BartchDrake Nugent
RGDominick PuniJon Feliciano
RTColton McKivitz
LDENick BosaRobert BealAlex BarrettJonathan Garvin
LDTMaliek CollinsKevin Givens
RDTJavon HargraveJordan ElliottKalia DavisEvan Anderson
RDELeonard FloydYetur Gross-MatosSam Okuayinonu
WLBDee Winters
MLBFred WarnerCurtis RobinsonTatum Bethune
SLBDe'Vondre CampbellDemetrius Flannigan-FowlesJalen Graham
LCBCharvarius Ward
SSMalik Mustapha
FSJi'Ayir BrownGeorge OdumJaylen Mahoney
RCBIsaac YiadomRock Ya-SinDarrell Luter
PMitch Wishnowsky
HMitch Wishnowsky
PRTrent TaylorRicky Pearsall
KRRicky PearsallTrent Taylor
LSTaybor Pepper
KJake Moody
LWRBrandon AiyukRicky PearsallChris Conley
NBDeommodore LenoirRenardo GreenChase Lucas
FBKyle Juszczyk
RWRDeebo Samuel

Chargers vs. 49ers Odds Comparison

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Chargers at 49ers Team Totals

MatchupOverUnder
Chargers
0-1
N/A
N/A
49ers
6-11
N/A
N/A