Chargers vs 49ers Odds & Live Scores - August 23, 2025

Chargers at 49ers

12:30 am • NFL+

Los Angeles Chargers

0-4

23 - 30

San Francisco 49ers

4-0

MatchupOpenSpreadTotalMoneyline
Chargers 0-4	-2.5-116	o35.5-118	-152
49ers 4-0	+2.5-103	u35.5-105	+125

Sunday 12:30 a.m.

August 24, 2025

Levi's StadiumSanta Clara

Under 36.5-115

1.25u

LAC -1.5-107

Under 37.5-105

0.53u

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NFL Public Betting

49ers are 4-0 in their last 5 games.
49ers are 3-1 in their last 5 games against the spread
The totals have gone OVER in 2 of 49ers' last 4 games
The totals have gone OVER in 2 of 49ers' 3 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
49ers	3-1	2-1	N/A	2-1	1-0
Chargers	0-3-1	0-2	0-1-1	0-2	0-1-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
49ers	2-2	2-1	N/A	2-1	0-1
Chargers	1-3	0-2	1-1	0-2	1-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
49ers	4-0	N/A	N/A	3-0	1-0
Chargers	0-4	N/A	N/A	0-2	0-2

date	opponent	score	spread	over/under	moneyline
Aug 16th	@LV	W 22-19	+4.5 W	O 40.5	SF +180
Aug 10th	DEN	L 9-30	+6.5 L	O 38.5	DEN +240
Jan 5th	@ARI	L 24-47	+5.5 L	O 43.5	ARI +195
Dec 31st	DET	L 34-40	+4 L	O 50.5	DET +182
Dec 22nd	@MIA	L 17-29	-1.5 L	O 44	MIA -125

Kyle Juszczyk
FB
Juszczyk is out with knee
Out
Demarcus Robinson
WR
Robinson is out with ankle
Out
Christian Kirk
WR
Kirk is out with calf
Out
Jake Tonges
TE
Tonges is out with knee
Out
De'Zhaun Stribling
WR
Stribling is out with ankle
Out

David Njoku
TE
Njoku is out with leg
Out
Gary Jennings
WR
Gary Jennings (Concussion) is out this week.
Out

Charlie Kolar
TE
Kolar is questionable with arm
Questionable
Quentin Johnston
WR
Johnston is out with chest
Out
Ladd McConkey
WR
McConkey is doubtful with foot
Doubtful
KeAndre Lambert-Smith
WR
Lambert-Smith is out with hamstring
Out
Brenen Thompson
WR
Thompson is out with quad
Out

See more NFL Injuries

Chargers

Total

49ers

321

Total Yards

238

Total Plays

4.7

Yards Per Play

3.8

Chargers

Passing

49ers

239

YDS

174

24/44

Comps/Atts

18/27

5.432

YPA

5.345

2/1

TDs/INTs

2/0

0/0

Sacks/Yards

2/19

Chargers

Rushing

49ers

Rush Yards

Attempts

3.417

YPC

2.515

TDs

Chargers

Turnovers

49ers

Fumbles Lost

Interceptions

Chargers

Efficiency

49ers

1/3 33.33%

Redzone

2/2 100%

3/13 0%

3rd Down

3/13 0%

1/1 0%

4th Down

0/1 0%

Chargers

First Downs

49ers

Total

Pass

Rush

Penalty

Chargers

Misc

49ers

11/74

Penalties/Yards

12/67

30:03

Possession

29:57

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MatchupOverUnder
Chargers 0-4	N/A	N/A
49ers 4-0	N/A	N/A

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49ers

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Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

49ers vs. Chargers Injury Updates

49ers Injuries

Chargers Injuries

Chargers vs. 49ers Odds Comparison

Chargers at 49ers Team Totals