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Rams vs. 49ers Odds & Betting Predictions - November 9, 2025

Rams at 49ers

9:25 pm • FOX

Los Angeles Rams

5-2
@

San Francisco 49ers

5-2

Rams at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Rams
5-2
N/A
N/A
N/A
49ers
5-2
N/A
N/A
N/A
location pinSunday 9:25 p.m.
November 09, 2025
Levi's StadiumSanta Clara

Rams vs. 49ers Props

Prop Projections

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Prop Odds Comparison

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Rams vs. 49ers Public Betting Percentages

Away Logo

Rams

Public

Home Logo

49ers

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • 49ers are 3-2 in their last 5 games.
  • 49ers are 2-3 in their last 5 games against the spread
  • 49ers are 3-1 in their road games against the spread
  • The totals have gone OVER in 3 of 49ers' last 5 games
  • The totals have gone OVER in 1 of 49ers' 3 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers		4-31-23-12-22-1
Rams		5-22-12-15-10-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers		4-31-23-12-22-1
Rams		3-41-22-12-41-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers		5-2N/AN/A3-12-1
Rams		5-2N/AN/A5-10-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Oct 20thATLW 20-10-0.5 WU 46.5SF -105
Oct 12th@TBL 19-30+3.5 LO 47TB +160
Oct 3rd@LAW 26-23+7.5 WO 43.5SF +340
Sep 28thJACL 21-26-3.5 LO 45.5JAC -172
Sep 21stARIW 16-15-1.5 LU 44.5SF -125

Rams vs. 49ers Injury Updates

Rams Injuries

  • Puka Nacua
    WR

    Nacua is out with ankle

    Out

49ers Injuries

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Brock Purdy
    QB

    Purdy is out with toe

    Out

  • Ricky Pearsall
    WR

    Pearsall is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

  • Jordan James
    RB

    James is doubtful with finger

    Doubtful

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Mac Jones logo
    Mac Jones
    1252
    pyds
  • passing touchdowns
    Mac Jones logo
    Mac Jones
    6
    ptd
  • rushing yards
    Christian McCaffrey logo
    Christian McCaffrey
    336
    ryds
  • rushing touchdowns
    Christian McCaffrey logo
    Christian McCaffrey
    1
    rtd
Depth Charts
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Starter2ND3RD4TH
QBBrock PurdyMac JonesKurtis Rourke
RBChristian McCaffreyIsaac GuerendoJordan James
WRJauan JenningsJacob CowingSkyy MooreJunior Bergen
TEGeorge KittleLuke FarrellJake Tonges
LTTrent WilliamsSpencer Burford
LGBen BartchNick Zakelj
CJake BrendelMatt HennessyDrake Nugent
RGDominick PuniConnor ColbyDrew Moss
RTColton McKivitzAusten Pleasants
LDENick BosaYetur Gross-MatosRobert BealWilliam Bradley-King
RDEMykel WilliamsBryce HuffSam OkuayinonuTrevis Gipson
WLBDee WintersNick MartinJalen Graham
MLBFred WarnerLuke GiffordTatum BethuneCurtis Robinson
LCBRenardo GreenJakob Robinson
SSJi'Ayir BrownMalik MustaphaDerrick Canteen
FSJason PinnockMarques SigleSiran Neal
RCBDeommodore LenoirDarrell Luter
PThomas Morstead
PRJacob CowingJunior BergenJordan WatkinsRicky Pearsall
KRIsaac GuerendoJunior Bergen
LSJon Weeks
NTJordan ElliottC.J. WestKalia Davis
NBUpton StoutChase Lucas
LWRBrandon AiyukRussell GageMalik Turner
FBKyle Juszczyk
RWRRicky PearsallJordan WatkinsMalik Turner
DTKevin GivensAlfred CollinsSebastian ValdezEvan Anderson
Team Stats

Passing

1615
YDS
1749
139/210
Comps/Atts
161/241
8.019
YPA
7.627
12/2
TDs/INTs
10/7
11/69
Sacks/Yards
13/89

Rushing

635
Rush Yards
493
146
Attempts
161
4.349
YPC
3.062
4
TDs
1

Turnovers

Fumbles Lost
2
Interceptions
7

Efficiency

13/26 50%
Redzone
9/21 42.86%
27/67 0%
3rd Down
39/86 0%
6/10 0%
4th Down
6/10 0%

First Downs

128
Total
132
78
Pass
90
38
Rush
31
12
Penalty
11

Misc

/
Penalties/Yards
/
Possession

Rams vs. 49ers Odds Comparison

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Rams at 49ers Team Totals

MatchupOverUnder
Rams
5-2
N/A
N/A
49ers
5-2
N/A
N/A