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Falcons vs. 49ers Odds & Betting Predictions - October 20, 2025

Falcons at 49ers

12:20 am • NBC

Atlanta Falcons

2-2
@

San Francisco 49ers

4-2

Falcons at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Falcons
2-2
+6.5
+3-105
o46-110
+145
49ers
4-2
u47.5
-3-115
u46-110
-175
location pinMonday 12:20 a.m.
October 20, 2025
Levi's StadiumSanta Clara
thermometer image69°Fahrenheit
rain image0%Rain
wind image6Wind

Falcons vs. 49ers Props

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Falcons vs. 49ers Public Betting Percentages

Away Logo

Falcons

Public

Home Logo

49ers

57%

Bets%

43%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • 49ers are 3-2 in their last 5 games.
  • 49ers are 2-3 in their last 5 games against the spread
  • 49ers are 3-1 in their road games against the spread
  • The totals have gone OVER in 3 of 49ers' last 5 games
  • The totals have gone OVER in 1 of 49ers' 2 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers		3-30-23-12-21-1
Falcons		2-21-11-11-11-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers		4-21-13-12-22-0
Falcons		1-31-10-21-10-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers		4-2N/AN/A3-11-1
Falcons		2-2N/AN/A1-11-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Oct 12th@TBL 19-30+3.5 LO 47TB +160
Oct 3rd@LAW 26-23+7.5 WO 43.5SF +340
Sep 28thJACL 21-26-3.5 LO 45.5JAC -172
Sep 21stARIW 16-15-1.5 LU 44.5SF -125
Sep 14th@NOW 26-21-3 WO 40.5SF -160

Falcons vs. 49ers Injury Updates

Falcons Injuries

  • Jamal Agnew
    WR

    Agnew is out with groin

    Out

  • Darnell Mooney
    WR

    Mooney is out with hamstring

    Out

  • DeMarcco Hellams
    S

    Hellams is out with hamstring

    Out

  • Jack Nelson
    OL

    Nelson is out with calf

    Out

49ers Injuries

  • George Kittle
    TE

    Kittle is out with hamstring

    Out

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Brock Purdy
    QB

    Purdy is out with toe

    Out

  • Ricky Pearsall
    WR

    Pearsall is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

  • Jordan Watkins
    WR

    Watkins is doubtful with ankle

    Doubtful

  • Jordan James
    RB

    James is doubtful with finger

    Doubtful

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Mac Jones logo
    Mac Jones
    1252
    pyds
  • passing touchdowns
    Mac Jones logo
    Mac Jones
    6
    ptd
  • rushing yards
    Christian McCaffrey logo
    Christian McCaffrey
    336
    ryds
  • rushing touchdowns
    Christian McCaffrey logo
    Christian McCaffrey
    1
    rtd
Depth Charts
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Starter2ND3RD4TH
QBBrock PurdyMac JonesKurtis Rourke
RBChristian McCaffreyIsaac GuerendoJordan James
WRJauan JenningsJacob CowingSkyy MooreJunior Bergen
TEGeorge KittleLuke FarrellJake TongesBrayden Willis
LTTrent WilliamsSpencer Burford
LGBen BartchNick Zakelj
CJake BrendelMatt HennessyDrake Nugent
RGDominick PuniConnor ColbyDrew Moss
RTColton McKivitzAusten Pleasants
LDENick BosaYetur Gross-MatosWilliam Bradley-King
RDEMykel WilliamsBryce HuffSam OkuayinonuTrevis Gipson
WLBDee WintersNick MartinJalen Graham
MLBFred WarnerLuke GiffordTatum BethuneCurtis Robinson
LCBRenardo GreenJakob Robinson
SSJi'Ayir BrownMalik MustaphaDerrick Canteen
FSJason PinnockMarques SigleSiran Neal
RCBDeommodore LenoirDarrell Luter
PThomas Morstead
PRJacob CowingJunior BergenJordan WatkinsRicky Pearsall
KRIsaac GuerendoJunior Bergen
LSJon Weeks
NBUpton StoutChase Lucas
LWRBrandon AiyukRussell GageMalik Turner
FBKyle Juszczyk
NTJordan ElliottC.J. WestKalia DavisBruce Hector
RWRRicky PearsallJordan WatkinsMalik Turner
DTKevin GivensAlfred CollinsSebastian ValdezEvan Anderson
Team Stats

Passing

905
YDS
1749
83/132
Comps/Atts
161/241
7.174
YPA
7.627
3/3
TDs/INTs
10/7
5/42
Sacks/Yards
13/89

Rushing

546
Rush Yards
493
127
Attempts
161
4.299
YPC
3.062
4
TDs
1

Turnovers

Fumbles Lost
3
Interceptions
7

Efficiency

6/13 46.15%
Redzone
9/21 42.86%
23/55 0%
3rd Down
39/86 0%
4/8 0%
4th Down
6/10 0%

First Downs

83
Total
132
46
Pass
90
31
Rush
31
6
Penalty
11

Misc

/
Penalties/Yards
/
Possession

Falcons vs. 49ers Odds Comparison

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Falcons at 49ers Team Totals

MatchupOverUnder
Falcons
2-2
N/A
N/A
49ers
4-2
N/A
N/A