49ers vs. Rams Odds & Betting Predictions - October 3, 2025

49ers at Rams

12:15 am • Amazon Prime Video

Stream Live on SiriusXM - Free 3 Month Offer

San Francisco 49ers

@

Los Angeles Rams

MatchupOpenSpreadTotalMoneyline
49ers 2-0	N/A	N/A	N/A
Rams 2-0	N/A	N/A	N/A

location pin

Friday 12:15 a.m.

October 03, 2025

SoFi StadiumInglewood

There are no prop projections found for the selected slate. Please check back later.

No props found

NFL Public Betting

Rams are 2-0 in their last 5 games.
Rams are 2-0 in their last 5 games against the spread
Rams are 1-0 in their road games against the spread
The totals have gone OVER in 1 of Rams' last 2 games
The totals have gone OVER in 0 of Rams' 1 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Rams	2-0	1-0	1-0	2-0	N/A
49ers	2-0	N/A	2-0	2-0	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Rams	1-1	0-1	1-0	1-1	N/A
49ers	1-1	N/A	1-1	1-1	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Rams	2-0	N/A	N/A	2-0	N/A
49ers	2-0	N/A	N/A	2-0	N/A

date	opponent	score	spread	over/under	moneyline
Sep 14th	@TEN	W 33-19	-5.5 W	O 41.5	LA -250
Sep 7th	HOU	W 14-9	-3 W	U 43	LA -168
Aug 23rd	@CLE	L 17-19	+10 W	U 37	CLE +360
Aug 16th	LAC	W 23-22	+8 W	O 39.5	LA +297
Aug 9th	DAL	W 31-21	+2.5 W	O 36	LA +120

Colby Parkinson
TE
Parkinson is out with shoulder
Out

Demarcus Robinson
WR
Robinson is out with suspension
Out
George Kittle
TE
Kittle is out with hamstring
Out

Eddy Pineiro
K
Pineiro is questionable with knee
Questionable
Brandon Aiyuk
WR
Aiyuk is out with knee
Out
Brock Purdy
QB
Purdy is out with toe
Out
Jacob Cowing
WR
Cowing is out with hamstring
Out
Jordan Watkins
WR
Watkins is doubtful with ankle
Doubtful
Jordan James
RB
James is doubtful with finger
Doubtful

See more NFL Injuries

passing yards
Matthew Stafford
543
pyds
passing touchdowns
Matthew Stafford
3
ptd
rushing yards
Kyren Williams
132
ryds
rushing touchdowns
Blake Corum
1
rtd

	Starter	2ND	3RD	4TH
QB	Matthew Stafford	Jimmy Garoppolo	Stetson Bennett
RB	Kyren Williams	Blake Corum	Jarquez Hunter	Ronnie Rivers
WR	Tutu Atwell	Xavier Smith
TE	Tyler Higbee	Colby Parkinson	Terrance Ferguson	Davis Allen	Mark Redman
LT	Alaric Jackson	D.J. Humphries	AJ Arcuri
LG	Steve Avila	Wyatt Bowles
C	Coleman Shelton	Beaux Limmer	Dylan McMahon
RG	Kevin Dotson	Justin Dedich
RT	Rob Havenstein	Warren McClendon	David Quessenberry
RDE	Braden Fiske	Larrell Murchison	Desjuan Johnson
LCB	Darious Williams	Emmanuel Forbes	A.J. Green	Cam Lampkin
SS	Kam Curl	Jaylen McCollough
FS	Kamren Kinchens	Tanner Ingle	Nate Valcarcel
RCB	Ahkello Witherspoon	Cobie Durant
P	Ethan Evans
H	Ethan Evans
PR	Xavier Smith
KR	Jordan Whittington	Blake Corum
LS	Alex Ward
LWR	Davante Adams	Jordan Whittington	Tru Edwards
NB	Quentin Lake	Josh Wallace
K	Joshua Karty
LOLB	Byron Young	Jamil Muhammad
NT	Poona Ford	Ty Hamilton	Bill Norton
RILB	Omar Speights	Elias Neal
RWR	Puka Nacua	Konata Mumpfield	Brennan Presley
DT	Kobie Turner	Tyler Davis	Jack Heflin
ROLB	Jared Verse	Josaiah Stewart	Nick Hampton
LILB	Nate Landman	Troy Reeder	Shaun Dolac

Total

Passing

532

YDS

514

52/74

Comps/Atts

44/62

7.514

YPA

8.758

5/2

TDs/INTs

3/1

4/24

Sacks/Yards

4/29

Rushing

196

Rush Yards

221

62

Attempts

50

3.161

YPC

4.42

0

TDs

3

Turnovers

Fumbles Lost

2

Interceptions

1

Efficiency

4/7 57.14%

Redzone

5/9 55.56%

15/29 0%

3rd Down

12/25 0%

2/2 0%

4th Down

2/2 0%

First Downs

47

Total

40

30

Pass

25

12

Rush

11

5

Penalty

4

Misc

/

Penalties/Yards

/

Possession

Could not load odds

See more NFL Odds

MatchupOverUnder
49ers 2-0	N/A	N/A
Rams 2-0	N/A	N/A