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49ers vs. Rams Odds & Betting Predictions - October 3, 2025

49ers at Rams

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San Francisco 49ers

6-11
@

Los Angeles Rams

1-1

49ers at Rams Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
6-11
N/A
N/A
+101
Rams
1-1
N/A
N/A
-121
location pinFriday 12:15 a.m.
October 03, 2025
SoFi StadiumInglewood

49ers vs. Rams Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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49ers vs. Rams Public Betting Percentages

Away Logo

49ers

Public

Home Logo

Rams

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Rams are 4-1 in their last 5 games.
  • Rams are 4-1 in their last 5 games against the spread
  • Rams are 5-3 in their road games against the spread
  • The totals have gone OVER in 2 of Rams' last 5 games
  • The totals have gone OVER in 5 of Rams' 9 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Rams		9-84-55-34-35-4
49ers		5-124-51-75-80-4

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Rams		8-95-43-51-66-3
49ers		10-75-45-37-63-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Rams		10-7N/AN/A6-14-5
49ers		6-11N/AN/A6-70-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jan 19th@PHIL 22-28+7 WO 43.5PHI +300
Jan 14thMINW 27-9+2.5 WU 47.5LA +112
Jan 5thSEAL 25-30+7.5 WO 38.5SEA +275
Dec 29thARIW 13-9-6.5 LU 48LA -305
Dec 22nd@NYJW 19-9-3 WU 47LA -157

Rams vs. 49ers Injury Updates

Rams Injuries

  • Ahkello Witherspoon
    CB

    Witherspoon is questionable with thigh

    Questionable

  • Troy Reeder
    LB

    Reeder is out with hamstring

    Out

  • Larrell Murchison
    DE

    Murchison is out with foot

    Out

  • Alaric Jackson
    OL

    Jackson is questionable with chest

    Questionable

  • Britain Covey
    WR

    Covey is out with neck

    Out

  • Byron Young
    OLB

    Young is questionable with knee

    Questionable

  • Nick Hampton
    OLB

    Hampton is questionable with triceps

    Questionable

  • Jared Verse
    DE

    Verse is questionable with ankle

    Questionable

  • Blake Corum
    RB

    Corum is out with arm

    Out

  • Tyler Davis
    DT

    Davis is questionable with calf

    Questionable

  • Beaux Limmer
    OL

    Limmer is questionable with knee

    Questionable

  • KT Leveston
    OL

    Leveston is out with ankle

    Out

  • Justin Dedich
    OL

    Dedich is questionable with illness

    Questionable

  • Josh Wallace
    DB

    Wallace is questionable with hip

    Questionable

49ers Injuries

  • Trent Williams
    T

    Williams is out with ankle

    Out

  • Christian McCaffrey
    RB

    McCaffrey is out with knee

    Out

  • George Kittle
    TE

    Kittle is questionable with ankle

    Questionable

  • George Odum
    S

    Odum is out with knee

    Out

  • Greg Joseph
    K

    Joseph is out with abdomen

    Out

  • Kevin Givens
    DE

    Givens is questionable with groin

    Questionable

  • Andre Dillard
    OL

    Dillard is questionable with concussion

    Questionable

  • Mitch Wishnowsky
    P

    Wishnowsky is out with back

    Out

  • Brandon Aiyuk
    WR

    Aiyuk is out with leg

    Out

  • Colton McKivitz
    OL

    McKivitz is questionable with knee

    Questionable

  • Ben Bartch
    OL

    Bartch is out with ankle

    Out

  • Deommodore Lenoir
    DB

    Lenoir is out with shoulder

    Out

  • Spencer Burford
    OL

    Burford is out with calf

    Out

  • Brock Purdy
    QB

    Purdy is out with elbow

    Out

  • Ji'Ayir Brown
    S

    Brown is questionable with ankle

    Questionable

  • Robert Beal
    DE

    Beal is out with ankle

    Out

  • Darrell Luter
    CB

    Luter is doubtful with pelvis

    Doubtful

  • Renardo Green
    DB

    Green is questionable with neck

    Questionable

See more NFL Injuries Right Arrow
Depth Charts
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Starter2ND3RD4TH
QBMatthew StaffordStetson Bennett
RBKyren WilliamsBlake CorumRonnie Rivers
WRCooper KuppJordan Whittington
TEColby ParkinsonDavis AllenHunter Long
LTAlaric JacksonJoseph NoteboomAJ ArcuriConor McDermott
LGJonah JacksonKT Leveston
CSteve AvilaBeaux Limmer
RGKevin DotsonJustin Dedich
RTRob HavensteinWarren McClendon
LCBDarious WilliamsTre TomlinsonJosh Wallace
SSKam CurlKamren KinchensJaylen McCollough
FSJohn JohnsonTanner Ingle
RCBCobie DurantCam Lampkin
PKJoshua Karty
PEthan Evans
HEthan Evans
PRTutu Atwell
KRTutu Atwell
LSAlex Ward
LILBChristian RozeboomTroy Reeder
LWRDemarcus RobinsonTutu AtwellXavier Smith
NTBobby BrownTyler DavisDavid Olajiga
LOLBJared VerseMichael Hoecht
DEBraden FiskeDesjuan Johnson
ROLBByron YoungBrennan JacksonNick HamptonKeir Thomas
DTKobie TurnerLarrell Murchison
NBQuentin LakeShaun JollyCharles Woods
RWRPuka NacuaTyler JohnsonDrake Stoops
KOEthan Evans
RILBJake HummelOmar SpeightsElias Neal

49ers vs. Rams Odds Comparison

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49ers at Rams Team Totals

MatchupOverUnder
49ers
6-11
N/A
N/A
Rams
1-1
N/A
N/A