49ers vs. Rams Odds & Betting Predictions - October 3, 2025

49ers at Rams

12:15 am • Amazon Prime Video
26 - 23

49ers at Rams Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
6-1
+7.5-105
o43.5-115
+340
Rams
2-4
-7.5-115
u43.5-108
-430
location pinFriday 12:15 a.m.
October 03, 2025
SoFi StadiumInglewood
49ers vs. Rams Expert Picks
YBK Picks.com
Last 30d: 45-46-2 (-6.2u)
Under 43.5-105
2u
SF +8.5-110
5u
SF +5.5-108
5u
J.Tonges o3.5 Recs+140
5u
Kody Malstrom
Kody Malstrom
Last 30d: 72-60-2 (+2.0u)
J.Whittington Anytime TD Scorer Yes+575
0.5u
Always tail @ChrisRaybon nfl player props
Over 43.5-110
0.5u
Sean Koerner🔮
Sean Koerner🔮
Last 30d: 55-68-0 (+1.5u)
M.Jones o32.5 Pass Att-128
0.5u
I’m projecting Mac closer to 34.1 attempts tonight. San Francisco is now sitting as a 7.5 to 8.5-point dog with Brock Purdy out, and their top two starting WRs already ruled out. Brandon Aiyuk and George Kittle are still out as well. So, yes, he’s working with second and third-string receivers, but those are actually the guys he’s thrown to the most in practice. Kendrick Bourne in particular already has chemistry with Mac from their time together in New England. They’re expected to play from behind at a much higher rate than they have been this season, which naturally pushes their playcalling in a more pass-heavy direction even with the downgraded receiver group. When Mac has been under center, the 49ers have posted a +9.6% PROE compared to -2.7% with Purdy. Probably just noise, but still a massive swing. The biggest thing working for pass attempts here is how stationary Mac is. He has scrambled once all year and is supposedly wearing a knee brace tonight, so the chances of him taking off are even lower. If he drops back and doesn’t get sacked, it’s usually going in the books as a pass attempt. He’s also throwing the ball away at a high rate this season, which is exactly the kind of empty play you want when betting this type of prop. His average depth of target is 7.0 compared to Purdy’s 7.6. That may not sound like much, but lower aDOT quarterbacks can rack up a couple of extra attempts just by checking down more often. All of these factors lead Mac to deserving a higher pass attempt prop than we would give Purdy here. One last edge that I don’t think is being priced in at all: Rams kicker Josh Karty basically mastered the new kickoff rule already. Opposing teams are starting drives at their own 21.7-yard line on average, which is dead last in the league. Longer fields equal more potential plays, which equals more dropbacks, which equals more attempts. I like the Over at 32.5 up to -140
Anthony Dabbundo
Anthony Dabbundo
Last 30d: 47-66-0 (-20.8u)
Under 46.5-102
1.02u
Doug Ziefel
Doug Ziefel
Last 30d: 427-417-9 (+35.7u)
C.McCaffrey u16.5 Rush Att-102
0.51u
D.Adams Anytime TD Scorer Yes (Live)+278
0.2u
P.Nacua u95.5 Rec Yds+100
0.5u
Under 47.5-115
0.58u
L.Farrell o5.5 Rec Yds-105
0.5u
Matt DiLeo
Matt DiLeo
Last 30d: 31-31-0 (-1.9u)
M.Jones o31.5 Pass Att-105
0.95u
Both Teams To Make 33+ Yard FG-125
0.8u
J.Tonges o27.5 Rec Yds-109
0.92u
Ryan Minion
Ryan Minion
Last 30d: 249-234-3 (+27.2u)
Under 44.5-110
$1.10
SF u17.5 Team Total-125
$1.25
LA -4.5 (1H)-110
$1.10
Grant Neiffer
Grant Neiffer
Last 30d: 24-83-4 (+0.4u)
D.Adams Anytime TD Scorer Yes+125
0.5u
K.Bourne 60+ Receiving Yards Yes+225
0.23u
K.Bourne Anytime TD Scorer Yes+350
0.25u
K.Bourne 90+ Receiving Yards Yes+900
0.9u
K.Bourne 100+ Receiving Yards Yes+1300
1.3u
K.Bourne 80+ Receiving Yards Yes+600
0.6u
K.Bourne 70+ Receiving Yards Yes+375
0.38u
OldSchool0909
Last 30d: 51-59-1 (-3.4u)
LA -3.5+100
1u
Under 43.5-104
1u
K.Juszczyk o9.5 Rec Yds-110
0.91u
B.Robinson o17.5 Rush Yds-110
1u
Collin Whitchurch
Collin Whitchurch
Last 30d: 118-167-3 (-0.0u)
Under 21.5 (2H)-108
0.54u
D.Robinson o16.5 Longest Reception-110
0.5u
M.Jones u5.5 Rush Yds-105
0.5u
Sandy Plashkes
Sandy Plashkes
Last 30d: 115-115-4 (+23.6u)
SF +9-115
1u
MJC
MJC
Last 30d: 9-12-0 (+6.5u)
D.Adams o4.5 Recs-118
1u
Buying low on Davante Adams here He’s seen 8, 13, 8, and 6 targets in 4 games so far but is only over this line in 1/4 games. He’s had 3 drops which is unlike him and is something I expect him to correct. Per PFF, he has struggled more so on “short (0-9)” targets (2025): • 17 targets / 7 rec / 41.2% rec% / 2 drops Here are his numbers on short targets over the past 2 seasons: 2024: 72 targets / 48 rec / 66.7 rec% 2023: 79 targets / 56 rec / 70.9% rec% I think ifs safe to say we can expect some positive regression. Fantasy Points agrees, he’s a big positive regression candidate as his expected fantasy points greatly exceeds his actual fantasy points. SF also plays a high rate of zone coverage (9th most) which is ideal for receptions. Adams has only caught 5 of 13 targets (38.5% rec%) with 3 drops vs zone this season. Last 2 seasons Adams caught 71.2% & 67% of his targets vs zone so we can expect his 2025 catch% to positively regress. Its also worth noting that PFF projects Adams matchups to look like this: 16.67 proj snaps vs Upton Stout 11.09 proj snaps vs Darrell Luter Jr. 11.09 proj snaps vs Deommodore Lenoir Stout has been the worst corner of the bunch with a below avg 48.6 pff coverage grade and 10 receptions allowed in 2025.
The Degenerates
The Degenerates
Last 30d: 59-58-2 (-2.7u)
SF +8.5-110
1u
Kyle Murray
Kyle Murray
Last 30d: 159-148-10 (+16.4u)
M.Jones o21.5 Pass Comp-101
1.19u
C.McCaffrey o115.5 Rush + Rec Yds-115
1u
D.Adams Anytime TD Scorer Yes+120
1u
D.Robinson o28.5 Rec Yds-115
1.17u
Lock & Cash
Lock & Cash
Last 30d: 7-8-0 (-0.1u)
C.McCaffrey u63.5 Rush Yds-110
0.91u
Brian Bitler
Brian Bitler
Last 30d: 72-84-4 (-32.3u)
Under 45.5-110
3u
SF +8.5-110
2.73u
Austin Pendergrass
Austin Pendergrass
Last 30d: 74-50-0 (+10.7u)
J.Tonges o2.5 Recs-168
0.5u
RoyalsProps
RoyalsProps
Last 30d: 35-48-2 (-19.3u)
J.Whittington o10.5 Rec Yds-110
1u
365
Gilles Gallant
Gilles Gallant
Last 30d: 26-67-1 (-1.7u)
B.Robinson o18.5 Rush Yds-115
0.58u
Grabbing at 18.5 but still like it at 19.5 too.
K.Bourne Anytime TD Scorer Yes+360
0.5u
#Tailing @gneiffer07
M.Valdes-Scantling Anytime TD Scorer Yes+1300
0.1u
Taking a crack on a longshot TD to pair with Bourne
D.Adams Anytime TD Scorer Yes+145
1u
IYKYK
Player Prop Savant
Player Prop Savant
Last 30d: 87-77-0 (+9.0u)
C.McCaffrey u15.5 Rush Att+104
1u
Got 16.5 on show this morning
Allan Lem
Allan Lem
Last 30d: 48-36-1 (+1.7u)
M.Jones o32.5 Pass Att-128
0.5u
Tailing @The_Oddsmaker
SF +8.5-102
0.5u
Action IG channel best bet - let’s tail!
Mjaybrod
Mjaybrod
Last 30d: 57-78-1 (-23.1u)
Over 44 (Live)-110
0.91u
Cam Is Money
Cam Is Money
Last 30d: 0-0-0 (+0.0u)
Under 47.5-115
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 101-111-1 (+21.9u)
C.McCaffrey u6.5 Recs+115
1.5u
K.Williams 2+ TDs Yes+360
1.08u
LA -5.5 (1H)-110
1.1u
Scott Rickenbach
Scott Rickenbach
Last 30d: 100-94-2 (-5.6u)
Under 43.5-105
1u
John Feltman
John Feltman
Last 30d: 108-64-1 (+27.5u)
M.Jones o33.5 Pass Att-114
5u
Sir Lockselot
Sir Lockselot
Last 30d: 18-39-0 (+4.2u)
D.Adams Anytime TD Scorer Yes+105
2u
📚Player Profit 🔑 D.Adams ATTD +105 (Player Profit) 2u 5 ⭐️ grade, 🟢 matchup and a 53.1% expected win probability For BA tools 👉 https://www.betalytics.com/ Promo code: LOCKSELOT for 25% off Code: sirlocks for 10% off every deposit at https://www.playerprofit.com/ Lets cash
New Owner
New Owner
Last 30d: 0-0-0 (+0.0u)
P.Nacua u95.5 Rec Yds-106
1.89u
POD
SF +8.5-104
0.96u
The Propfessor
The Propfessor
Last 30d: 0-0-0 (+0.0u)
D.Robinson 40+ Receiving Yards Yes+174
0.25u
K.Williams o67.5 Rush Yds-112
1u
D.Robinson 50+ Receiving Yards Yes+288
0.15u
D.Robinson o27.5 Rec Yds-114
0.66u
Lines at Lunch
Lines at Lunch
Last 30d: 0-0-0 (+0.0u)
C.McCaffrey o15.5 Rush Att-138
1u
LA -4.5 (1H)-107
1.07u
P.Nacua o100 Rec Yds+100
1u
LA -4.5 (1H)-112
1.12u
Babs .
Babs .
Last 30d: 52-38-1 (+7.8u)
J.Whittington o10.5 Rec Yds-115
0.87u
Player Props
Player Props
Last 30d: 0-0-0 (+0.0u)
C.McCaffrey u62.5 Rush Yds-113
0.88u
B.Corum Last TD Scorer Yes+1400
0.1u
D.Adams o53.5 Rec Yds-112
0.89u
Roger Goodell
Roger Goodell
Last 30d: 0-0-0 (+0.0u)
SF +8.5-105
0.95u
C.McCaffrey u62.5 Rush Yds-113
0.44u
Bet Labs
Bet Labs
Last 30d: 13-12-0 (-0.8u)
LA -2.5 (2H)-176
1u
DeadPresPicks
DeadPresPicks
Last 30d: 0-1-0 (-1.0u)
J.Tonges First Touchdown Scorer Yes+2000
3u
SF +7-105
0.52u

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49ers vs. Rams Props

Prop Projections

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49ers vs. Rams Public Betting Percentages

Away Logo

49ers

Public

42%

Bets%

58%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Rams
2-41-21-12-30-1
49ers
4-32-21-12-32-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Rams
3-31-22-02-31-0
49ers
3-42-21-12-31-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Rams
2-4N/AN/A2-30-1
49ers
6-1N/AN/A4-12-0

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 28thINDW 27-20-3.5 WU 49.5LA -190
Sep 21st@PHIL 26-33+3.5 LO 45.5PHI +170
Sep 14th@TENW 33-19-5.5 WO 41.5LA -250
Sep 7thHOUW 14-9-3 WU 43LA -168
Aug 23rd@CLEL 17-19+10 WU 37CLE +360

49ers vs. Rams Injury Updates

49ers Injuries

  • Mike Evans
    WR

    Evans is out with achilles

    Out

  • Demarcus Robinson
    WR

    Robinson is out with ankle

    Out

  • Deebo Samuel
    WR

    Samuel is out with hamstring

    Out

  • Jake Tonges
    TE

    Tonges is out with knee

    Out

  • De'Zhaun Stribling
    WR

    Stribling is out with ankle

    Out

Rams Injuries

  • Davante Adams
    WR

    Adams is out with hamstring

    Out

  • Ronnie Rivers
    RB

    Rivers is out with calf

    Out

  • Puka Nacua
    WR

    Nacua is questionable with calf

    Questionable

  • Terrance Ferguson
    TE

    Ferguson is out with ankle

    Out

Team Stats
407
Total Yards
456
83
Total Plays
64
4.9
Yards Per Play
7.1

Passing

342
YDS
389
33/49
Comps/Atts
30/47
6.66
YPA
7.875
2/0
TDs/INTs
3/0
1/9
Sacks/Yards
1/11

Rushing

74
Rush Yards
78
33
Attempts
16
2.242
YPC
4.875
0
TDs
0

Turnovers

0
Fumbles Lost
2
0
Interceptions
0

Efficiency

2/5 40%
Redzone
3/5 60%
7/18 0%
3rd Down
4/10 0%
3/3 0%
4th Down
2/3 0%

First Downs

27
Total
27
19
Pass
18
6
Rush
5
2
Penalty
4
8/44
Penalties/Yards
5/36
40:04
Possession
26:20

49ers vs. Rams Odds Comparison

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49ers at Rams Team Totals

MatchupOverUnder
49ers
6-1
N/A
N/A
Rams
2-4
N/A
N/A