49ers vs. Buccaneers Odds & Betting Predictions - October 12, 2025
49ers at Buccaneers
8:25 pm • CBS49ers at Buccaneers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
49ers 7-1 | +3.5-110 | o47-110 | +160 | |
Buccaneers 3-6 | -3.5-110 | u47-110 | -190 | |

Raymond James StadiumTampa
49ers vs. Buccaneers Expert Picks
Vegas Refund
Last 30d: 27-38-1 (-14.8u)
SF +3.5-110
1.1u
Stuck 🚨
Last 30d: 51-57-1 (-0.2u)
TB -150
0.17u
Took piece off 49ers after Mac Jones didn’t throw yesterday. Shanahan saying he “should be able to play” isn’t the most encouraging endorsement. Can add back if all good. Looks like no Pearsall. Jennings limited has a chance.
SF +6.5 (Live)-102
0.1u
Why not
SF +3-105
0.6u
Mike McNamara
Last 30d: 72-66-1 (+5.1u)
SF +3.5-105
0.3u
Matt Moore
Last 30d: 96-77-2 (+7.9u)
SF +3-110
1.1u
Kenny Ducey
Last 30d: 1-1-0 (-0.2u)
TB -3-107
1u
Sean Koerner🔮
Last 30d: 60-66-1 (+4.9u)
T.Smith o6.5 Tackles + Ast-108
0.54u
Projecting closer to 7.6 with around a 60% chance to go over 6.5
Anthony Dabbundo
Last 30d: 41-51-0 (-5.7u)
Over 47-110
1u
Doug Ziefel
Last 30d: 366-310-10 (+33.9u)
Over 46.5-110
0.5u
R.White u60.5 Rush Yds-110
0.55u
TB -2.5-114
0.5u
Ryan Minion
Last 30d: 236-272-8 (-26.0u)
TB -3-110
$1.00
E.Egbuka o72 Rec Yds-130
$1.30
R.White Anytime TD Scorer Yes-135
$1.00
R.White o84.5 Rush + Rec Yds-115
$1.00
OldSchool0909
Last 30d: 75-51-0 (+18.8u)
SF +2.5 (Live)+100
1u
Collin Whitchurch
Last 30d: 137-191-3 (+5.7u)
T.Smith o6.5 Tackles + Ast-128
0.64u
The Degenerates
Last 30d: 90-83-2 (-0.7u)
Over 47.5-108
1u
Sunday Six Pack
Last 30d: 0-0-0 (+0.0u)
SF +3-105
1.05u
@Stuckey2 1 https://myaction.app/S6McBO2wkXb
Brian Bitler
Last 30d: 76-80-0 (-12.7u)
SF +3.5-112
3u
Nick Giffen
Last 30d: 48-166-0 (+8.4u)
C.McCaffrey u12.5 Longest Rush-115
0.5u
Discord prop
Allan Lem
Last 30d: 54-43-1 (+0.3u)
C.McCaffrey u12.5 Longest Rush-115
0.25u
Tailing @nick_giffen
T.Smith o6.5 Tackles + Ast-108
0.27u
Tailing @The_Oddsmaker
SF +3.5-110
0.55u
Action IG channel best bet - let’s tail!
Andrew O’Connor-Watts
Last 30d: 74-80-4 (+3.8u)
TB -155
0.15u
TB -3-120
0.15u
Action Pod NFL Picks
Last 30d: 38-112-1 (-16.9u)
SF +3-105
1u
@sundaysixpack @Stuckey2 https://myaction.app/S6McBO2wkXb
The Favorites Podcast
Last 30d: 0-0-0 (+0.0u)
SF +3+100
1u
@Stuckey2 https://myaction.app/62yRjm1UlXb
Mjaybrod
Last 30d: 49-71-1 (-23.5u)
Under 47.5-105
1u
💰🦡 Jake
Last 30d: 93-106-0 (+19.5u)
B.Mayfield Anytime TD Scorer Yes+450
0.1u
Scott Rickenbach
Last 30d: 101-107-0 (-18.4u)
Over 46.5-116
0.86u
John Feltman
Last 30d: 78-62-2 (+4.6u)
SF +3-115
3.45u
T.Smith u6.5 Tackles + Ast (Live)-180
3u
T.Smith o5.5 Tackles + Ast-108
5u
SF +4.5 (Live)-111
3.33u
Wags Wins
Last 30d: 278-267-2 (-15.5u)
Under 47-110
1.25u
New Owner
Last 30d: 0-0-0 (+0.0u)
C.McCaffrey u50 Rec Yds+100
1u
SF +3.5 (Live)+111
1u
Under 47.5-108
1u
The Propfessor
Last 30d: 0-0-0 (+0.0u)
R.White o3.5 Recs-120
1u
Babs .
Last 30d: 29-21-1 (+6.4u)
C.Otton o29.5 Rec Yds-114
0.88u
R.White o24.5 Rec Yds-108
1u
Bet Labs
Last 30d: 4-1-0 (+2.9u)
SF +3.5-120
1.2u
TAN Pod Touchdown Show
Last 30d: 23-90-1 (-7.9u)
D.Robinson Anytime TD Scorer Yes+450
0.5u
@GDAWG5000 https://myaction.app/QzEiDAmkmXb
E.Egbuka Anytime TD Scorer Yes+135
0.5u
@GDAWG5000 https://myaction.app/QzEiDAmkmXb
49ers vs. Buccaneers Previews & Analysis
49ers vs. Buccaneers Props
Prop Projections
There are no prop projections found for the selected slate. Please check back later.
Prop Odds Comparison
Line Movement Tracker
49ers vs. Buccaneers Public Betting Percentages
Betting Trends
- Buccaneers are 2-3 in their last 5 games.
- Buccaneers are 2-3 in their last 5 games against the spread
- Buccaneers are 3-1 in their road games against the spread
- The totals have gone OVER in 1 of Buccaneers' last 5 games
- The totals have gone OVER in 2 of Buccaneers' 5 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 4-5 | 1-4 | 3-1 | 1-1 | 3-4 | |
| 5-3 | 3-2 | 1-1 | 3-3 | 2-0 |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 5-4 | 2-3 | 3-1 | 1-1 | 4-3 | |
| 4-4 | 3-2 | 1-1 | 3-3 | 1-1 |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 3-6 | N/A | N/A | 1-1 | 2-5 | |
| 7-1 | N/A | N/A | 5-1 | 2-0 |
Last 5 Matchups
Buccaneers vs. 49ers Injury Updates

Buccaneers Injuries
- Jalen McMillanWR
McMillan is out with knee
Out

49ers Injuries
- Mike EvansWR
Evans is doubtful with achilles
Doubtful
- Christian KirkWR
Kirk is out with knee
Out
- Deebo SamuelWR
Samuel is questionable with hamstring
Questionable
- Jake TongesTE
Tonges is out with knee
Out
- De'Zhaun StriblingWR
Stribling is out with ankle
Out
Team Stats
49ers vs. Buccaneers Odds Comparison
Could not load odds
49ers at Buccaneers Team Totals
MatchupOverUnder | ||
|---|---|---|
49ers 7-1 | N/A | N/A |
Buccaneers 3-6 | N/A | N/A |




