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Bills vs. Rams NFL Odds, Lines: Opening Spread & Over/Under for 2022 Thursday Night Season Opener

Bills vs. Rams NFL Odds, Lines: Opening Spread & Over/Under for 2022 Thursday Night Season Opener article feature image

Photo by Andy Lyons/Getty Images. Pictured: Matthew Stafford #9 of the Los Angles Rams and Sean McVay the head coach

The 2022 NFL regular season will officially get underway with the Buffalo Bills visiting the reigning Super Bowl champion Los Angeles Rams on Thursday, Sept. 8 (8:20 p.m. ET, NBC) at SoFi Stadium.

The Rams are essentially bringing back the core of their team from last season, including the addition of wide receiver Allen Robinson with Odell Beckham Jr., who is recovering from a torn ACL, unlikely to return.

Buffalo comes into 2022 largely intact as well coming off its heartbreaking playoff loss to the Kansas City Chiefs in the AFC Divisional Round, with the addition of linebacker Von Miller as the biggest offseason splash.

Bills vs. Rams is certainly a heavyweight bout to start the 2022 NFL season, and as is typically the case, sportsbooks wasted no time posting odds immediately to satiate the ravenous appetites of football bettors.

So let’s not waste anymore time and jump right into opening odds for Bills vs. Rams on Sept. 8.

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Bills vs. Rams Odds

*Odds as of May 13 and via DraftKings Sportsbook

Bills vs. Rams Spread

  • Rams: -1 (-105)

With both teams at full strength as of right now, it’s no surprise to see the Rams favored at home.

However, it is interesting to note that this number suggests that the Bills may have the higher overall power rating of the two teams before adjusting for home-field advantage.

That said, the Rams’ home-field advantage is among the lowest in the league.

Bills vs. Rams Over/Under

  • Over/Under: 52

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