The Buffalo Bills (10-4) and Cleveland Browns (3-11) meet in Week 16 on Sunday, Dec. 21. Kickoff is set for 1:00 p.m. ET from Huntington Bank Field in Cleveland, Ohio. The game will broadcast live on CBS.
The Bills are 10.5-point favorites over the Browns on the spread (Bills -10.5; -105), the game total is 41.5. Buffalo is a -575 favorite to win outright on the moneyline, while Cleveland is +425 to pull off the upset.
Let's get into my Week 16 preview and Bills vs Browns prediction for today's game.
Bills vs Browns Prediction
- Bills vs Browns pick: Under 41.5 (-110)
My Bills vs Browns best bet is on the under. Find the best lines by checking our live NFL odds page.
Bills vs Browns Odds
| Bills Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-10.5 -105 | 41.5 -110o / -110u | -575 |
| Browns Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+10.5 -115 | 41.5 -110o / -110u | +425 |
Bills vs Browns NFL Week 16 Preview
At the time of writing, it's unclear if the Browns are going to have a functional offensive line in this game.
G Joel Bitonio missed practice Wednesday and logged a limited one on Thursday due to a knee injury while T Jack Conklin is dealing a concussion. G Teven Jenkins is dealing with a shoulder injury, and David Njoku, their best blocking tight end, seems to miss practice the first two days every week — he didn't play last week logged DNPs Wednesday and Thursday.
RB Dylan Sampson, who has provided some juice out of the backfield in the receiving game, has also been a DNP for most of the week with a hand injury.
Long story short: The Browns offense is injury ravaged, which is bad news for Shedeur Sanders, who came crashing back down to earth in a 31-3 loss to the Bears last week.
That's what I was afraid of, which is why I didn't bet the Browns in that game, and it's looking like this is setting up for a similar kind of result against the Bills today.
Bills vs Browns Prediction, Betting Analysis
The Bills are a little bit overrated, in my opinion. They beat the Bengals at home and needed a miracle comeback against the Patriots. The defense remains flawed and nothing to write home about.
There's going to be a ton of running in this game from both teams, which will constantly bleed clock.
Pick: Under 41.5 (-110)
Spread
I'm not betting either side of the spread in this contest.
Moneyline
No play on the moneyline.
Over/Under
My Browns vs Bills betting prediction is on the under.
