NFL Preseason Odds, Picks, Predictions: Early Bets for Panthers vs. Commanders, Colts vs. Bills (Aug. 13)

NFL Preseason Odds, Picks, Predictions: Early Bets for Panthers vs. Commanders, Colts vs. Bills (Aug. 13) article feature image
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Justin Casterline/Getty Images. Pictured: Matt Ryan.

NFL Preseason Quarterback Matchups

This will be updated before every slate of preseason games.


Chiefs vs. Bears

Patrick Mahomes is expected to start and play about one quarter. However, Andy Reid has exaggerated how long he will play Mahomes in previous preseasons.

I might wait for Mahomes to play a series before potentially coming in on the Bears and/or the under (either on the 1H or full game line) in hopes of catching the market before it adjusts to Mahomes being done for the day.

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Panthers vs. Commanders

The Panthers will start Baker Mayfield, who will play 1-2 series, followed by Sam Darnold, who will play 1-2 series. PJ Walker should finish up the first half, then we should see rookie Matt Corral play most of the second half.

The Commanders will play Carson Wentz for about one quarter before turning it over to Taylor Heinicke. Then they'll let rookie Sam Howell play most of the second half.

Considering this is a game where both teams will likely take a close look at their QBs, I could see them both playing aggressively on offense.

All of these QBs are at or near replacement level, and we won’t be seeing any truly awful ones under center. I’m taking the full-game over at 37.5.

Pick: Over 37.5

Colts vs. Bills

The Cots are expected to play Matt Ryan and the starters for most of the first quarter before turning it over to Nick Foles in the second.

Josh Allen won’t suit up, which means Case Keenum will get the start for the Bills.

The Colts have the edge for the first half, and the Bills should have the edge in the second half. That means I’m taking the Colts +105 for the 1H.

Pick: Colts 1H +105

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