Patriots vs. Bills Odds, Picks & Predictions

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Photo credit: Greg M. Cooper-USA TODAY Sports. Pictured: Tom Brady

Patriots at Bills Betting Odds, Picks & Predictions

  • Spread: Patriots -7
  • Total: 41.5
  • Time: 1 p.m. ET
  • TV Channel: CBS

Odds as of Sunday and via PointsBet, where Action Network users get an exclusive 200% deposit match (deposit $50, bet with $150).


Our analysts and experts break down the most important angles of this game.

Here’s an excerpt, but you can read the full thing here.

New England’s defense isn’t as good as the numbers it’s put up. Obviously.

The Pats have yet to allow an offensive touchdown while holding opponents to a league-leading 3.8 yards per play. That’s simply unsustainable, as they’ve clearly benefited from an extremely easy schedule that’s included the Steelers, Dolphins and Jets — three teams with zero combined wins.

That said, the Patriots defense — which hasn’t allowed a touchdown since the AFC Championship Game and is the first in NFL history to not allow a rushing or receiving TD in the first three games — is undoubtedly elite.

And it all starts with their cornerbacks.

See our full betting breakdown for Patriots-Bills here.

Our Favorite Bets for Sunday’s Main Slate

Our staff breaks down how they’re betting the 1 and 4 p.m. ET games. See their favorite picks.

Sean Koerner’s Projected Patriots-Bills Odds

Sean Koerner uses his NFL Power Ratings to project odds for every game. See whether he thinks this spread or total are worth a bet.

Pick ‘Em Confidence Rating

Sean Koerner ranks every straight-up and against-the-spread pick for pools in his Pick ‘Em Confidence Ratings.

See where the Patriots and Bills rank.

Survivor Pool Recommendations

Should you roll with either New England or Buffalo in Week 4? Our NFL simulations reveal the best survivor pool picks.

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